DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Alk

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster

Alignment Length:	678	Identity:	173/678 - (25%)
Similarity:	264/678 - (38%)	Gaps:	172/678 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 GLATGGGSCQWRGSNSAMFG-----TRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIV 609
            |...|||.|...|......|     |........|...|......:.|::          ||...
  Fly   989 GFGGGGGGCNTGGGGGGYAGGDVYLTESNGEGGSSYISPSRSLREISEIH----------AGASS 1043

  Fly   610 GPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPR---------KRKNETEAEPLLGV 665
            ||.:..     |..|...|.|:    ..|..|||  ...|.|         ||.|.|..|    :
  Fly  1044 GPGAII-----IIPAIEGCGCD----YRCVALDE--FRSKVRCICPDGWSLKRDNHTACE----I 1093

  Fly   666 RRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSM 730
            |.                      |..:|...::::..::.:.:|...:.|...||..|..::..
  Fly  1094 RE----------------------EAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQ 1136

  Fly   731 TTSSKQALPESGGGDFALMPLQ--------SGFRFESG-----------DAKWEFPREKLQLDTV 776
            :....:.|.|.   |..|..|:        :.|....|           ::..:..|:.|||...
  Fly  1137 SKKRHKMLVEQ---DLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNA 1198

  Fly   777 LGEGEFGQVL-------KGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNV 834
            ||:|.||:|.       .|.|.|:.       ||||.|::.....:....|.|..::.:.:|||:
  Fly  1199 LGKGAFGEVYMALYRHRDGDAVEMG-------VAVKTLREDPKREKEEDFLKEAAIMAKFNHPNM 1256

  Fly   835 IKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGM 899
            :.|:|.|...:...:::|....|.|:.:||.:|       :..:....:.:|.:|..|..:.||.
  Fly  1257 VHLIGVCFDRQPYYIVLELLAGGDLQKFLRENR-------NTPERPSLLTMKDLLFCALDVAKGC 1314

  Fly   900 AYLSELKLVHRDLAARNVLLAD---GKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLA 961
            .|:...:.:|||:||||.||:.   |::.||:|||::||:|..|.|.|..:..:|:|||.||:..
  Fly  1315 RYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFL 1379

  Fly   962 DHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWA 1026
            |.::|||:||||||:|.||:.:||.|||||.....:..|:..|.|:..|..|..::|.::..||.
  Fly  1380 DGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWN 1444

  Fly  1027 DEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGEPESLQHLWSPPK 1091
            ..|..||:|..|   .|.|..                  |..|::::...|            |.
  Fly  1445 PTPEDRPTFITL---LEHLTA------------------CTQDASIMNAPL------------PN 1476

  Fly  1092 I----AYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRP------LLDATANGQVLRYENDLRFPL 1146
            |    |.:..|........||    ...|.|.|.:|.|      ...|:.:|.|...:..
  Fly  1477 ILGPTASERDDTVIRPPNGEE----FCLAVPDYLVPLPPGGSNNPSMASGSGYVPELQRQ----- 1532

  Fly  1147 NIRKSSCTPSYSNMTSEPPATTS--LPH 1172
              :.||||         |||.||  .||
  Fly  1533 --QMSSCT---------PPAVTSPAAPH 1549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	99/288 (34%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	97/280 (35%)
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	100/292 (34%)
		TyrKc	1193..1460	CDD:197581	98/283 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455304
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940