Protein Alignment Ret and PDGFRB

DIOPT Version :9

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_002600.1
• Gene: PDGFRB / 5159
• HGNCID: 8804
• Length: 1106
• Species: Homo sapiens
• Alignment Length: 1068
• Identity: 254/1068 - (23%)
• Similarity: 395/1068 - (36%)
• Gaps: 332/1068 - (31%)

  Fly   304 YAVHNDSHGLFRPDCHAYEADHTGRPHTIV-SCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDA 367
            :..||||.||        |.|...|.:..| ...:.|..|..  |..:....|..::||..||..
Human    99 FCTHNDSRGL--------ETDERKRLYIFVPDPTVGFLPNDA--EELFIFLTEITEITIPCRVTD 153

  Fly   368 MSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVS-- 430
            ......         |||.:.::  |||:.....|     .|:|....||....|...|::|.
Human   154 PQLVVT---------LHEKKGDV--ALPVPYDHQR-----GFSGIFEDRSYICKTTIGDREVDSD 202

  Fly   431 ---VYRSAAS-------------------------------NF----------RVVQP--DSFLD 449
               |||...|                               ||          |:|:|  |..||
Human   203 AYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLD 267

  Fly   450 L-MRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINV 513
            : ..:||| ..|...:|...| |.|..:....|....|:|      :|:|.::.   .:||::.
Human   268 MPYHIRSI-LHIPSAELEDSG-TYTCNVTESVNDHQDEKA------INITVVES---GYVRLLG- 320

  Fly   514 HLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSC--- 575
                   |..:.:.....||:| .|:.::         |....:..|...|..:..:..|..
Human   321 -------EVGTLQFAELHRSRT-LQVVFE---------AYPPPTVLWFKDNRTLGDSSAGEIALS 368

  Fly   576 ---VPESRY-------------------------------------CPDHVCDPLEELNPMACPQ 600
               |.|:||                                     .|..|.: |.|.:|.:..|
Human   369 TRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLE-LSESHPDSGEQ 432

  Fly   601 DCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAE----- 660
            .....||  |....|.    |:||     |.|..:|        |:...|....|.:|.|
Human   433 TVRCRGR--GMPQPNI----IWSA-----CRDLKRC--------PRELPPTLLGNSSEEESQLET 478

  Fly   661 -----------PLLGVRRGTPPNQPLQDPMLLGVLNVAGFECD------RSCMFFVITCPLLFVL 708
                       .::...|....::||.  :...:.|..|.:..      .|..|.|:....:..|
Human   479 NVTYWEEEQEFEVVSTLRLQHVDRPLS--VRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILAL 541

  Fly   709 LLLCLL-IAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQ 772
            ::|.:: :....||.::..:..:.....:::...|.....:.|:|..:     |:.||.||::|.
Human   542 VVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPY-----DSTWELPRDQLV 601

  Fly   773 LDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HPNVIK 836
            |...||.|.||||::..|..::.......|||||||..:.|.|..||:||.:::..:. |.||:.
Human   602 LGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVN 666

  Fly   837 LLGACTSSEAPLLIIEYARYGSLRSYLRLSR---------------------------------- 867
            ||||||......:|.||.|||.|..||..::
Human   667 LLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVS 731

  Fly   868 ----------------------------KIECAGVDFADGVEP-----------------VNVKM 887
                                        .::.|.::.::.:.|                 :|...
Human   732 LTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESP 796

  Fly   888 VLT------FAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRS 946
            ||:      |::|:..||.:|:....|||||||||||:.:||:.||.||||.||:..|..|:.:.
Human   797 VLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKG 861

  Fly   947 RDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQN--LWSLLKTGYRMDR 1009
            ...:|:|||||||:.:.:||:.|||||||:|.||:.|||.:|||.: |.|  .::.:|.||||.:
Human   862 STFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPEL-PMNEQFYNAIKRGYRMAQ 925

  Fly  1010 PENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK----YID---------------- 1054
            |.:.|:.:|.|::.||.::...||.|..|....|:|||...|    .:|
Human   926 PAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQA 990

  Fly  1055 -----------LETNAVSNPLYC------GDDSALITTELGEPESLQH--LWSPPKIAYDIHDQA 1100
                       |:|::|   ||.      ||:..:|.....:||....  |...|.:|....::.
Human   991 RLPGFHGLRSPLDTSSV---LYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEV 1052

  Fly  1101 TSYDQSEEEMPVTSTAPPGYDLPRPLLD 1128
            .:......:.|:.....|.   |.|.|:
Human  1053 NTSSTISCDSPLEPQDEPE---PEPQLE 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	121/366 (33%)
		TyrKc	771..1042	CDD:197581	117/358 (33%)
PDGFRB	NP_002600.1	ig	37..114	CDD:278476	8/22 (36%)
		IG	40..110	CDD:214652	6/18 (33%)
		IG_like	222..310	CDD:214653	20/95 (21%)
		Ig1_PDGFR-alphabeta	228..312	CDD:143269	21/91 (23%)
		Ig4_PDGFR-alpha	314..415	CDD:143267	15/118 (13%)
		Ig	425..523	CDD:299845	22/118 (19%)
		PTKc_PDGFR_beta	562..953	CDD:133238	124/396 (31%)
		Pkinase_Tyr	600..953	CDD:285015	116/353 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1019..1106		11/62 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910