Protein Alignment Ret and PDGFRA

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001334757.1
• Gene: PDGFRA / 5156
• HGNCID: 8803
• Length: 1114
• Species: Homo sapiens
• Alignment Length: 1115
• Identity: 269/1115 - (24%)
• Similarity: 437/1115 - (39%)
• Gaps: 304/1115 - (27%)

  Fly   249 DIKLLDRNDNG----PKLQESSSK------FDFYLEQPYFQADEEAGKKV-IYV-DKDT----LE 297
            |:::.:..:|.    ..|:.||:.      :..|......:.:|..|:.: ||| |.|.    |.
Human    93 DVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLG 157

  Fly   298 ANAHLVYAVHNDSHGLFRPDCHAYEAD-----HTGRPHTIVSCQLRFSRNGVFRETPYCVSLEAR 357
            ...:||....:||..:   .|...:.:     |........|...|...||.|...||......:
Human   158 MTDYLVIVEDDDSAII---PCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVK 219

  Fly   358 D---LTIVSRVDAMSATANVCYHIN-LSKLHESEQELPQALPLRARQHRIFESE------EFNGD 412
            .   .||...|.|:.||:.:...:. |..:::|.:.:....       .:|.:|      .:.|:
Human   220 GKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTC-------AVFNNEVVDLQWTYPGE 277

  Fly   413 SAGR-----------------SLSPP--TVDYDKDVSVYRSAA-------------------SNF 439
            ..|:                 :|:.|  ||   ||...|..||                   ..|
Human   278 VKGKGITMLEEIKVPSIKLVYTLTVPEATV---KDSGDYECAARQATREVKEMKKVTISVHEKGF 339

  Fly   440 RVVQPD-SFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWI--D 501
            ..::|. |.|:.:.|..::..:||  :.|:   ....|.::||...|.|        |:|.|  |
Human   340 IEIKPTFSQLEAVNLHEVKHFVVE--VRAY---PPPRISWLKNNLTLIE--------NLTEITTD 391

  Fly   502 QQRLSHVRV-INVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNS 565
            .:::..:|. ..:.|:..:.|::.....|...........::        |.|     |...|..
Human   392 VEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFE--------LLT-----QVPSSIL 443

  Fly   566 AMFGTRYGS-------CVPESRYCPD---HVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRG 620
            .:....:||       |..|....||   .:|..:::.|.       ..:..|:..:.||....
Human   444 DLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNN-------ETSWTILANNVSNIITE- 500

  Fly   621 IYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQ--DPMLLGV 683
            |:|...:.:   .|:.:.|.::|...::        ..|:.|||..     |:.|:  .|.|...
Human   501 IHSRDRSTV---EGRVTFAKVEETIAVR--------CLAKNLLGAE-----NRELKLVAPTLRSE 549

  Fly   684 LNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPES---GGGD 745
            |.||.          .:...|:.|::.|.:|:.        :.||......:..:.||   .|.:
Human   550 LTVAA----------AVLVLLVIVIISLIVLVV--------IWKQKPRYEIRWRVIESISPDGHE 596

  Fly   746 FALM-PLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKK 809
            :..: |:|..:     |::|||||:.|.|..|||.|.||:|::|.|..::....:..|||||||.
Human   597 YIYVDPMQLPY-----DSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKP 656

  Fly   810 GSNSVEYMALLSEFQLLQEVS-HPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSR------ 867
            .:.|.|..||:||.:::..:. |.|::.||||||.|....:|.||..||.|.:||..:|
Human   657 TARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSH 721

  Fly   868 -------KIECAGVDFA------------------------------------------------ 877
                   :::..|::.|
Human   722 HPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSL 786

  Fly   878 -----------------------DGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLL 919
                                   |..|.:.:..:|:|.:|:.:||.:|:....||||||||||||
Human   787 YDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL 851

  Fly   920 ADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITL 984
            |.|||.||.||||.||:..|..|:.:....:|||||||||:.|::||:.|||||:|:|.||:.:|
Human   852 AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSL 916

  Fly   985 GASPYPG-IAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGN 1048
            |.:|||| :.....::.:|:||||.:|::.:..||.|:..||..||..||||..|:...|.||..
Human   917 GGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPG 981

  Fly  1049 NAK---------YIDLETNAVSNPLYCGDDSALITTELGEPESLQHLWSPPKIAYDIHDQATSYD 1104
            ..|         ::..:..||:......|::.:..|...|.:.|:. |..     .:.:|..|.|
Human   982 QYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKD-WEG-----GLDEQRLSAD 1040

  Fly  1105 QSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTS 1169
            .             ||.:|.|.:|.....:.|...|               .:|:.|||..|..:
Human  1041 S-------------GYIIPLPDIDPVPEEEDLGKRN---------------RHSSQTSEESAIET 1077

  Fly  1170 LPHYSVPVKR 1179
            ....|..:||
Human  1078 GSSSSTFIKR 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	126/364 (35%)
PDGFRA	NP_001334757.1	Ig_3	53..125	CDD:464046	5/31 (16%)
		IgI_PDGFR-alphabeta	237..335	CDD:409447	15/107 (14%)
		Ig strand A	237..241	CDD:409447	0/3 (0%)
		Ig strand A'	248..252	CDD:409447	0/3 (0%)
		Ig strand B	254..263	CDD:409447	0/15 (0%)
		Ig strand C	268..273	CDD:409447	0/4 (0%)
		Ig strand C'	276..278	CDD:409447	1/1 (100%)
		Ig strand D	282..290	CDD:409447	0/7 (0%)
		Ig strand E	294..302	CDD:409447	1/7 (14%)
		Ig strand F	312..318	CDD:409447	2/5 (40%)
		Ig strand G	323..329	CDD:409447	0/5 (0%)
		Ig4_PDGFR	338..438	CDD:409445	23/125 (18%)
		PTKc_PDGFR_alpha	580..981	CDD:173653	137/405 (34%)