DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and kitb

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001137390.1	Gene:	kitb / 497629	ZFINID:	ZDB-GENE-050916-2	Length:	957	Species:	Danio rerio

Alignment Length:	1067	Identity:	268/1067 - (25%)
Similarity:	418/1067 - (39%)	Gaps:	306/1067 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 YLCPHVSLE-------YSLNAGSSHFVLKQNRLYTRQ-------------TLDHDELNGLNAKAG 224
            |.|.:...|       |..:.||:......|.|..|:             .:.|..|...|..|
Zfish    90 YTCENTETEEKSSIYIYVKDLGSAFVRRMVNDLQVRKGEEITLPCLVTDPAVSHLSLQTCNGSA- 153

  Fly   225 QLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYF---QADEEAGK 286
             |.|.:|                    .:.....|..::..|..|    |..||   |.|::..|
Zfish   154 -LPAALT--------------------FITHPQGGITIRNVSKAF----EGCYFCAGQLDQKPVK 193

  Fly   287 KVIY----------VDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSR 341
            ...|          |...:|..|.:::.....:    |:..|.|...:|        ...||:
Zfish   194 SREYNLVVRLAPESVPAISLSRNENVILIQDQE----FKLSCSAVNINH--------DFHLRW-- 244

  Fly   342 NGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFES 406
                              ||.|...|:.:        :.|.:....:|..:::.|..:..:|.::
Zfish   245 ------------------TIPSEATALES--------HKSNIQPGSREYQRSITLWIQSVKINDT 283

  Fly   407 EEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGIT 471
            ..:..::..          :|.||:   ||.|..|.: ..|::|....:...::.|.:.....:.
Zfish   284 GSYRCNARN----------EKGVSM---AAVNLEVYE-RGFINLTEGENRVVEVREGESLTLSVE 334

  Fly   472 STS-----GIVFVKNPQVLEEAPETIYFLNVTWIDQQ--RLSHVRVINVHLVHGRPENTSCELKV 529
            .||     .:::..|.|.|:...|.:    :|..:||  .:|.:|::.||...|.....|...|.
Zfish   335 ITSYPKPNDVLWTYNNQELQNTSEHV----ITLHNQQYRYISELRLVRVHGSEGGIYTFSANHKY 395

  Fly   530 KSRSQT------CAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESR--YC-PDH 585
            :|.:|:      |..:....:     |...|...|           ...|..||:..  || |.|
Zfish   396 ESVNQSFTVHVICKPVIVSQE-----GPVDGQVRC-----------VASGYPVPKISWYYCEPPH 444

  Fly   586 V-CDPLEELNPMACPQD---CTPAGRIVGPHSSNENKRGIYSASG-----TCICEDNGKCSCAPL 641
            . |..|  ||.....::   .|.:|...| .|..|::..|  :.|     .|:....|:
Zfish   445 TRCSHL--LNATQADEEFAVITVSGSEFG-RSEVESRLNI--SKGKFHTLECVASAQGE------ 498

  Fly   642 DEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLF 706
                            :|..|..:...|.|:: |..|:|.||::.:
Zfish   499 ----------------QAYTLFSISERTVPHK-LFTPLLSGVVSTS------------------- 527

  Fly   707 VLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALM-PLQSGFRFESGDAKWEFPREK 770
            |||...|::...|.:|:  .|..:   ..:.:....|.::..: |.|..:     |.|||||||:
Zfish   528 VLLSFILVVLLYKYMQK--PKYEI---HWKVIDSFDGNNYTYIDPTQLPY-----DPKWEFPRER 582

  Fly   771 LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNV 834
            |:...:||.|.||:|:...|..:.....:|||||||||..::|.|..||:||.::|..: :|.|:
Zfish   583 LRFGKILGSGAFGKVVAATAYGLCSADTVTTVAVKMLKPSAHSTEKEALMSELKVLSYIGNHINI 647

  Fly   835 IKLLGACTSSEAPLLIIEYARYGSLRSYLRLSR----------------------KIECAGVDFA 877
            :.||||||.....|:|.||..||.|.::||..|                      .||  |.|
Zfish   648 VNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDAFFSSKTGDGYYKNLLSQTQPSIE--GTD-- 708

  Fly   878 DGVEP---------------------VNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLAD 921
            :|..|                     ::.:.:|:|::|:.|||.:|:....:|||||||||||..
Zfish   709 NGYMPMRSYQKRSNQTEWCDDKDDLSLDTEDLLSFSYQVAKGMDFLTSKNCIHRDLAARNVLLTQ 773

  Fly   922 GKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGA 986
            |::.||.||||.||:..|..|:.|...|:|||||:||||...|||.:|||||:|:|.||:.:||.
Zfish   774 GRVAKICDFGLARDITRDSNYVLRGNARLPVKWMSPESLFACVYTFESDVWSYGILLWEIFSLGN 838

  Fly   987 SPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNA 1050
            :||||| .....:.:::.||||..||.....:|.::|.||:.:|..||.||.|....|.||....
Zfish   839 TPYPGIPVGSTFYKMIQDGYRMSEPEFAPSEIYEVMRWCWSADPLKRPPFKKLVERTELLLSETT 903

  Fly  1051 K--YIDLETNAVSNPLYCGDDSALITTELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVT 1113
            |  |::|.|:        |...|.:...|..|:.|..:.|
Zfish   904 KHDYLNLSTS--------GSCEAFVPPGLQRPQRLSSVGS------------------------- 935

  Fly  1114 STAPPGYDLPRPLLDATANGQVLRYEN 1140
            |||.     .:|||.|| |...|.:::
Zfish   936 STAS-----TQPLLQAT-NDVFLEHQS 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	126/323 (39%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	123/315 (39%)
kitb	NP_001137390.1	IG_like	121..201	CDD:214653	19/105 (18%)
		Ig	209..305	CDD:299845	22/148 (15%)
		IG	225..305	CDD:214652	20/132 (15%)
		Ig	309..407	CDD:299845	21/101 (21%)
		I-set	319..406	CDD:254352	19/90 (21%)
		PKc_like	547..896	CDD:304357	134/360 (37%)
		Pkinase_Tyr	583..894	CDD:285015	123/314 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910