Protein Alignment Ret and Abl

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 159/564 - (28%)
• Similarity: 239/564 - (42%)
• Gaps: 118/564 - (20%)

  Fly   726 GKQSMTTSSK----------QALPESGGGDFALMPL---------QSGFRFESGDAKWEFPREKL 771
            ||..:|..:|          .::|..|.|  .:.||         .:.|.......:||..|..:
  Fly   327 GKVFVTQEAKFNTLAELVHHHSVPHEGHG--LITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDI 389

  Fly   772 QLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMAL---LSEFQLLQEVSHPN 833
            .:...||.|::|:|.:.......     .|||||.||:     :.|||   |.|..:::|:.|||
  Fly   390 MMKHKLGGGQYGEVYEAVWKRYG-----NTVAVKTLKE-----DTMALKDFLEEAAIMKEMKHPN 444

  Fly   834 VIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKG 898
            :::|:|.||......:|.|:..:|:|..:||            :.|.|.::...:|..|.||..|
  Fly   445 LVQLIGVCTREPPFYIITEFMSHGNLLDFLR------------SAGRETLDAVALLYMATQIASG 497

  Fly   899 MAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADH 963
            |:||.....:||||||||.|:.|.|:.|::||||.| :..||.|...:..:.|:||.|||.||.:
  Fly   498 MSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYN 561

  Fly   964 VYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADE 1028
            .:::|||||:||||.||:.|.|.||||.|...:::..|..||||:||..|...||.::|.||..:
  Fly   562 KFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWD 626

  Fly  1029 PNGRPSFK-------------FLASEFEKLLGNNAKYID---------------LETNAVSNPLY 1065
            ...||:||             .:....||.|..||....               ..|.|.|.
  Fly   627 ATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASG--- 688

  Fly  1066 CGDDSALITTELGEPESLQ------HLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPR 1124
            |...|:...:....|:.::      ...:|.....|.|.|..|...||...  |||
  Fly   689 CASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGS--TST--------- 742

  Fly  1125 PLLDATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKRGRSYL--DMT 1187
            .|...::.|:.           |::....|.........||..|||    :...|..:|.  |..
  Fly   743 KLSTFSSQGKG-----------NVQMRRTTNKQGKQAPAPPKRTSL----LSSSRDSTYREEDPA 792

  Fly  1188 N-KSLIPDNLDSREFEK-----HLSKTISFRFSSLLNLSETKEV 1225
            | :....|:|.:....|     :.|:|:|..|.:.:....|.::
  Fly   793 NARCNFIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQI 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	107/294 (36%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189	9/37 (24%)
		PTKc_Abl	382..644	CDD:270645	107/284 (38%)
		FABD	1584..1723	CDD:197885