Protein Alignment Ret and drl

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 592
• Identity: 147/592 - (24%)
• Similarity: 228/592 - (38%)
• Gaps: 148/592 - (25%)

  Fly   498 TWIDQQRLSHVR------VINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCG-----L 551
            ||....:.|..|      .|||.::..|..|.:..|..| |.:.|.:.:..|....|..     |
  Fly   112 TWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFK-RKKICLREEQDSAHEEYDDDDLDLL 175

  Fly   552 ATG----GGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPH 612
            .|.    ||...:...|.                  :||                     :...|
  Fly   176 QTARKGHGGDIHYVDRND------------------EHV---------------------VANGH 201

  Fly   613 SSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQD 677
            .:.|.:|.:.:.|..    ..|....:..|.:|.::           |.|:      ||...|..
  Fly   202 QAPEKQRPVVTESPV----GRGNSGGSKRDFDPMLR-----------ENLV------PPASGLVT 245

  Fly   678 PMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALP--- 739
            .::.|:|.:.                |:..|:|:..............|...:.|||.|.||
  Fly   246 LIVGGILALV----------------LVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTIS 294

  Fly   740 ESGGGDFALMP---------LQSGFRFESGDAKWEFPRE---------KLQLDTVLGEGEFGQVL 786
            .:......:.|         |...|| |......||.|.         :::|..::.||.||::.
  Fly   295 STAHNSIYVCPSTITPTYATLTRPFR-EYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIY 358

  Fly   787 KGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLII 851
            :|...:      ...|.||.:.:.::.::...||.|..:|.|.|||||:.:||......|...::
  Fly   359 RGTYND------CQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL 417

  Fly   852 EYARYGS---LRSYLRLSRKIECAGVDFADGVEPVNVKMVLT-----FAWQICKGMAYLSELKLV 908
             ||..||   |:|:|:                :|...:.|.|     ...|:...|.:|....::
  Fly   418 -YAATGSVRNLKSFLQ----------------DPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVI 465

  Fly   909 HRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWS 973
            |:|:||||.::.|....|::|..|:||::..|.......:..|:||::.|:|....|...|||||
  Fly   466 HKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWS 530

  Fly   974 FGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFL 1038
            ||||.||:.|||..||..|.|..:...||.|||:.:|.||.:.:::|:..|||..|..||||..|
  Fly   531 FGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQL 595

  Fly  1039 ---ASEF 1042
               .|||
  Fly   596 QICLSEF 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	93/284 (33%)
drl	NP_001260566.1	WIF	21..157	CDD:128745	13/45 (29%)
		PTK_Ryk	336..606	CDD:270639	93/290 (32%)