Protein Alignment Ret and Shark

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Alignment Length: 818
• Identity: 187/818 - (22%)
• Similarity: 289/818 - (35%)
• Gaps: 267/818 - (32%)

  Fly   250 IKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLF 314
            |...|...||.|:|...|||.:..:.||:.:.|                  ||:......|:||
  Fly   350 ISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVE------------------HLIAHFMRFSYGL- 395

  Fly   315 RPDCHAYEADHTGRPH-----TIVSCQLRFSRNGVFRETPYCVSLEARDLTIVS--------RVD 366
             |....|......:|.     ||....::          |...| .|...|.||        .|.
  Fly   396 -PVSLKYPVPPQPKPEVPSFATIPRSNMK----------PKAAS-PATPPTPVSPHSHHQHPHVP 448

  Fly   367 AMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEF--NGDSAGRSLSPPTVDYDKDV 429
            |::.|.        .|..|:...:...|.|.:.:..:|:....  |.....||        |.:.
  Fly   449 ALTITK--------KKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRS--------DSES 497

  Fly   430 SVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYF 494
            ||..|.|...:.:|..:.:    |:|:.|........|.|:|.:..           .|...:|
  Fly   498 SVSGSLAGTEQELQAAAPM----LKSLSFSTEFSTFNADGVTGSGA-----------AAAGEVY- 546

  Fly   495 LNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQ-TCAQIKYQSQCVRYCGLATGGGSC 558
             ||.                     ..||..|:.:...:| |.|:::|.::
  Fly   547 -NVP---------------------RNNTPIEIDLPPIAQKTEAEVEYFTK-------------- 575

  Fly   559 QWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPA-GRI--VGPHSSNENKRG 620
                |:.|:...|.|..:... |.|  ..|.|..|:    .|...|| .|:  :||::|.|::..
  Fly   576 ----SDVAIERERAGQWIGNG-YQP--TMDVLSLLD----QQIKAPAVARLNSLGPNASTESEMA 629

  Fly   621 IYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLN 685
            .|.         :.|||                              |||
  Fly   630 SYL---------HRKCS------------------------------GTP--------------- 640

  Fly   686 VAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMP 750
                                                        .|.|:.:.
  Fly   641 --------------------------------------------STPSATEV------------- 648

  Fly   751 LQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEI--AGLPGITTVAVKMLK-KGSN 812
                   |:...::....|||.||..:|.||||.|..|:....  ||......||:|||. :.||
  Fly   649 -------EAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSN 706

  Fly   813 SVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFA 877
            ..|:   |.|..::..:.|..:::|:| ....|..:::.|.|..||:..|:          :|..
  Fly   707 KQEF---LREASVMMRLEHKCIVRLIG-IAKGEMLMMVQELAPLGSMLQYI----------LDHG 757

  Fly   878 DGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDA- 941
            ..: ..|.::.: :|.||..||.||.....|||||||||:||......||||||::|.:.....
  Fly   758 HEI-TANAELKV-WASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTE 820

  Fly   942 YLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYR 1006
            |......|.|::|.||||....:::..||||||||..||:.:|||.||..|:..:...|:.:|.|
  Fly   821 YQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGER 885

  Fly  1007 MDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEK 1044
            :.:|..|...:|:::::||.:.|..||:|.:|...|.:
  Fly   886 LPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFAR 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	97/279 (35%)
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211	15/62 (24%)
		PTKc_Syk_like	666..926	CDD:270650	93/274 (34%)