DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and MAP3K11

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_002410.1 Gene:MAP3K11 / 4296 HGNCID:6850 Length:847 Species:Homo sapiens


Alignment Length:642 Identity:131/642 - (20%)
Similarity:233/642 - (36%) Gaps:157/642 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 VNLSAKEILDLAEEIIHKS--TRVHDAVALVSLDKLS--YENVVLPLAELEARQLSLIQCCVFPK 123
            |..:...:||.....|.|:  |...::||:|..|.|.  .::......:||  ||..:..|.:  
Human   393 VKSAEPHLLDTYAPEITKAFITSRLESVAIVVRDNLEDPLDDTATVFQQLE--QLCTVSRCEY-- 453

  Fly   124 MLSPHDNVRKASTEAEQKIDAHILSCRKREDVYRIIKIYAAKGESISPEAK----CYLQCLVRDF 184
                    .|..|...|..|.:..:.:|        .::||.|.::....:    .:|..||...
Human   454 --------EKTCTLLVQLFDQNAQNYQK--------LLHAAPGLAVDMAIQEGRLAWLIYLVGTV 502

  Fly   185 EDNGLNLTAIKREEVERLKYEIDELSLRYIQNLN-EDSSCLFFTEDELAGLPLEFLQNLEKTQNK 248
            .  |..||....:|.:.:.   .|||.|..|.:: .|:.....|.:::....|.||....||   
Human   503 V--GGRLTYTSTDEHDAMD---GELSCRVFQLISLMDTRLPHCTNEKIELAVLWFLDQFRKT--- 559

  Fly   249 EFKLTLESRHVAAILE-LCKIAKTRKTVAMAYGKRCGDTNIPVLQRLVQSRHRLACVCGYAHFAD 312
                     :|...|: ..|:.:.:..|:....|         ..::|:...|::.|.|... .:
Human   560 ---------YVGDQLQRTSKVVRPKNDVSRVPEK---------AWKIVKVYARMSEVLGITD-DN 605

  Fly   313 YALDRRMSK--TSM-----------RVIRFLEDISSS--LTDLAIREFSILEDLKRKEEGEIPF- 361
            :.|:..|:|  |::           |.::||.|:|..  |....::..::...||.......|| 
Human   606 HVLETFMTKIVTNLKYWGRCEPVISRTLQFLSDLSVGYILLKKLVKIDAVKFMLKNHTSEHFPFL 670

  Fly   362 GVED----------LLYYIKRVEELQFDL--DFGDIRQY-FPVNLVLSGIFKICQDLFGIKFEEV 413
            |:.:          ..:|......|..||  |..:...: .|:.:....:.:|..:.|  |.|||
Human   671 GISETYNVGDFRCRTTFYTALTRLLMVDLGEDEDEFENFMLPLTVSFETVLQIFNNNF--KQEEV 733

  Fly   414 TEVDVWY-HDIR--AFAVFDSGSGKLLGYF----YLDMFTREGKCNHSCVVALQNNALFSNGACQ 471
            ..:.:.. .|:|  |||:....|..:|..:    ||.:..|          |::.  .:...||.
Human   734 KRMLIGLARDLRGIAFALNTKTSYTMLFDWIYPAYLPVLQR----------AIER--WYGEPACT 786

  Fly   472 IPVALLIAQFAKDGSGEAVPLGFSDV-----VNLFHEFGHVV----QHICNRASFA-------RF 520
            .|:..|:|:..::.|..   |.| ||     :.||.|...::    ..|.:..|.:       :.
Human   787 TPILKLLAELMQNRSQR---LNF-DVSSPNGILLFREASKMICTYGNQILSLGSLSKDKIYPMKL 847

  Fly   521 SGLRVDPDFREIPSQLLENWCYESFTLKLISG------YRQDITKPLVDEVCKTLKRWRYSFSAL 579
            .|:.:  .:..:.|.|..|  |.||.:..:.|      ..|...|.|:......|.::|   ...
Human   848 KGISI--CYSALKSALCGN--YVSFGVFKLYGDNHFDNVLQAFVKMLLSVSHSDLLQYR---KLS 905

  Fly   580 KSLQEILYCLFDQIIYSDDDADLLQLIRSLHPKVMI--------GLPVVEGTNPASC 628
            :|...:|.||         ..|.:..|.:|.|.|::        ||..::....:||
Human   906 QSYYPLLECL---------TQDHMSFITNLEPPVLLYVLTSLSEGLTTLDTVVSSSC 953

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864
MAP3K11NP_002410.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11..38
SH3_MLK1-3 45..102 CDD:212992
STKc_MLK3 113..379 CDD:271049
Leucine-zipper 1 403..424 5/20 (25%)
Leucine-zipper 2 438..459 6/32 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..643 24/127 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..847 43/209 (21%)
Blue background indicates that the domain is not in the aligned region.

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