DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and htl

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	433	Identity:	150/433 - (34%)
Similarity:	230/433 - (53%)	Gaps:	59/433 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   694 SCMFFVITCPLLFVLL-LLCLLIAQRKMLQRRLGKQSMTTS---SKQAL---PESGGG-----DF 746
            |.::..:...|:|:.: .|.:..|.|||...::.||.:.|.   :|:.:   ||.||.     |.
  Fly   309 SFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDT 373

  Fly   747 ALMP-----------LQSG--------FRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATE 792
            .:||           ||:|        :.|.. |:.||.||..|.|...||||.||:|:......
  Fly   374 MIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPL-DSNWELPRSHLVLGATLGEGAFGRVVMAEVNN 437

  Fly   793 IAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HPNVIKLLGACTSSEAPLLIIEYARY 856
                   ..|||||:|:|....:..:|:.|.::::.:. |.|:|.|||.|:.:....:|:|||.:
  Fly   438 -------AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPH 495

  Fly   857 GSLRSYLRLSRKIECAGVD-FADGVEP--------VNVKMVLTFAWQICKGMAYLSELKLVHRDL 912
            |:|:.:|..:|..   |.| ..|..:|        :..|.::.||.||.:||.||:..:.:||||
  Fly   496 GNLKDFLYKNRPF---GRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDL 557

  Fly   913 AARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVL 977
            ||||||::|..:.||:||||.||:...|.|.|.:..|:|:||||||||.:..|.|||||||:|:|
  Fly   558 AARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGIL 622

  Fly   978 CWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASE 1041
            .||::|.|..|||.| :.:.|::.|.:|.||::|..||..:|.::|.||....:.||.|..:...
  Fly   623 LWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEY 687

  Fly  1042 FEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGEPESLQ 1084
            .:|||.....|:|::...:..|....|:      |..|.::||
  Fly   688 MDKLLQTKEDYLDVDIANLDTPPSTSDE------EEDETDNLQ 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	114/289 (39%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	111/281 (40%)
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	117/298 (39%)
		STYKc	416..688	CDD:214568	111/281 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455227
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940