DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Sdr

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	971	Identity:	187/971 - (19%)
Similarity:	302/971 - (31%)	Gaps:	370/971 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 SRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQH----------RIFESEEFNGDSAGRS 417
            |.|.|.|.....|..:.::|:.:          ||..|:          ...:..:.:|:.:..|
  Fly    30 SPVLASSDDQTACGSLEINKIAD----------LRKLQNCTHVVGHVRLAYVDLTDVSGNYSLDS 84

  Fly   418 LSPPTVDYDKDVSVYR-SAASNFRVVQPDSFLDLMRLRSIR-----FD-----IVEDK-LGAFGI 470
            |:....:....:.||| :...:.:.:.|       |||.||     ||     :.|:: |...|:
  Fly    85 LASNVTEISDYLMVYRCTGLISLQSIFP-------RLRIIRGQELLFDQYSLVVYENRNLRELGL 142

  Fly   471 TS----TSGIVFVKNPQVL--EEAPETIYFL-NVTWIDQQRLSHVRVINVHLVHGRPENTSCEL- 527
            ..    .||.:.|::..:|  .|..:.||.: |.|   :|..|        |.|.||: :.|.|
  Fly   143 VELLRIQSGFIRVESNPLLCFVETVDWIYLMGNAT---RQHFS--------LKHNRPQ-SQCPLC 195

  Fly   528 --------KVKSRSQTC-----AQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPES 579
                    .:::.|:.|     .|::.|...::.|.:|.|...|...|.
  Fly   196 GSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGK---------------- 244

  Fly   580 RYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTC-ICED-NGKCSCAPLD 642
              |.||.|                    :.|.:|.|            | :|.: .|:..|.
  Fly   245 --CCDHNC--------------------VTGCYSQN------------CSLCANYQGRMGCV--- 272

  Fly   643 EEPKMKKPRKRKNETEAEPLLGVRRGTPPNQ-------PLQDPMLLGVLNVAGFECDRSCMFFVI 700
                        |:..|...|..||.....:       ||          :.|::|       |.
  Fly   273 ------------NQCVASYELNKRRCIGHRECRELGRIPL----------IRGYQC-------VK 308

  Fly   701 TCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESG--------GGDFALMPLQSGFRF 757
            .||                      |.|      |:.|...|        .|||   .::|....
  Fly   309 KCP----------------------GNQ------KEILVAKGIIHCQVECNGDF---HVKSAADL 342

  Fly   758 E--------SGDAKWEFPREKLQLDTVLGEGEFGQV--LKGFATEI--AGLPGITTVAVKMLKKG 810
            |        :|....|....|.::...| |.....|  :.|:...|  |.|..:|.:......:|
  Fly   343 EVLQDCVTINGSLTIELTNIKEKIVDAL-ENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRG 406

  Fly   811 SNSVE--YMALLSEFQLLQEVSHPN--VIKLLGACTSSEAPLLIIE--YARYGSLRSYLRLS--- 866
            ...||  |...:.....|:.:..||  ||...|.......|.|..|  :...|||:|...:|
  Fly   407 DKLVENKYALYVVNNYHLEHIWPPNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVAD 471

  Fly   867 -------RKIECAGVDFADGVEPVN----------VKMVLTFA-WQICKGMAYLSELKLVHRDLA 913
                   .::.|     .|.|..:|          |:::|.:. |:   ||..|......:::..
  Fly   472 VSPNSNGERVIC-----GDAVRSLNPKVEDLNSTAVRIILDYMDWE---GMETLIGYSYHYKEAP 528

  Fly   914 ARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP--------ESLADHVYTSKSD 970
            .:||.:.||:      .|...|.:..|....:||..| :..:.|        ::|....|..:.|
  Fly   529 VQNVTMYDGR------HGCGHDNWLMDVVPNQSRRHV-ISGLKPYTQYAYFVKTLTRTEYHIQID 586

  Fly   971 VWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRM---DRPE------NCSEAVYSIVRTCWA 1026
            .:|                            |.||..   |||.      ..||....|:...|.
  Fly   587 AYS----------------------------KIGYFQTLPDRPSPVLRIYGSSEISSQILLHWWP 623

  Fly  1027 D-EPNGRPSFKFLASE------------FEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELG 1078
            . .|||.....|:.:|            :..:...|||.||.|...|. |.|.|.
  Fly   624 PRRPNGVIKNYFVTAEKYNATKEAKDKNYVNVELENAKDIDCECAGVL-PYYSGP---------- 677

  Fly  1079 EPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYENDLR 1143
            :|:. :..::..:|.|            |:.:|........:|..|...:     :|:.||:
  Fly   678 QPDD-EDYYNKEQITY------------EDALPNLIYVSRNHDYRRKEFE-----KVINYEH--- 721

  Fly  1144 FPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKRGRSYLDMTNKSLIPDNLDSREFEKH 1204
             .|:|:|       ....:.||.||..|               ||.:|..:.|.:..:|.:
  Fly   722 -LLSIKK-------DEEPTRPPTTTPAP---------------TNATLAKERLAAINYENY 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	67/339 (20%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	66/331 (20%)
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	24/121 (20%)
		Furin-like	209..332	CDD:279142	37/232 (16%)
		Recep_L_domain	347..461	CDD:279382	25/114 (22%)
		FN3	491..578	CDD:214495	19/96 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930