Protein Alignment Ret and lck

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001001596.1
• Gene: lck / 414333
• ZFINID: ZDB-GENE-040617-1
• Length: 503
• Species: Danio rerio
• Alignment Length: 567
• Identity: 154/567 - (27%)
• Similarity: 230/567 - (40%)
• Gaps: 179/567 - (31%)

  Fly   573 GSCVP--ESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGK 635
            ||..|  |..|.||..||...      ||:.         |.|.|.:
Zfish     5 GSFDPDDEFSYHPDEWCDQCN------CPKP---------PVSQNFD------------------ 36

  Fly   636 CSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNV-------AGFE--- 690
                ||...|....|                   ||:.||.:.:::.:...       .|||
Zfish    37 ----PLIPYPSQYTP-------------------PPSSPLPENLVVAIYKYDPAHSDDLGFEKGE 78

  Fly   691 ------CDRSCMFFVIT--------CPLLFVLLL------------LCLLIAQRKMLQRRLGKQS 729
                  ||....:...:        .|..||..|            |....|.|::|.....:.|
Zfish    79 KMKILDCDDPEWYMAESLFTGQRGYIPKNFVAKLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGS 143

  Fly   730 MTTSSKQALPESGGGDFA-----LMPLQSG----FRFESGDA----------------------- 762
            ......:..|    |.|:     |.|:|..    :|..:.||
Zfish   144 FLIRESETQP----GSFSISVRDLDPMQGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSR 204

  Fly   763 -------------------------KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTV 802
                                     :||.|||.|:|:..||:|:||:|..|...      ....|
Zfish   205 EADGLCTRLVKPCQTRAPQKPWWQDEWEVPRESLKLERRLGQGQFGEVWMGLYN------NNRQV 263

  Fly   803 AVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLS 866
            |:|.||.|:.|:.  |.|:|..|::.:.||.:::|....|  :.|:.|| ||...|||..:|:..
Zfish   264 AIKSLKPGTMSIS--AFLAEANLMKSLQHPRLVRLFAVVT--QEPIYIITEYMENGSLVDFLKTP 324

  Fly   867 RKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFG 931
            .     |.|.     |:|.  ::..|.|:.:||||:.:...:||||.|.|:|::....|||:|||
Zfish   325 E-----GSDI-----PINT--LIDMAAQVAEGMAYVEQKNYIHRDLRAANILVSHELTCKIADFG 377

  Fly   932 LTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQN 996
            |.| :.:::.|..|...:.|:||.|||::....::.||||||||||..|::|.|..||||:....
Zfish   378 LAR-LIKNNEYTAREGAKFPIKWTAPEAINYGTFSIKSDVWSFGVLLTEIVTYGRIPYPGMTNPE 441

  Fly   997 LWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            :.:.|:.||||..|:||.||:|::::.||.:.|:.||:|:||.|..|
Zfish   442 VIANLERGYRMPCPDNCPEALYNVMKHCWTENPDNRPTFEFLRSVLE 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	104/275 (38%)
lck	NP_001001596.1	SH3_Lck	57..111	CDD:212938	8/53 (15%)
		SH2_Src_Lck	116..216	CDD:198225	14/103 (14%)
		PTKc_Lck_Blk	230..493	CDD:270652	109/282 (39%)