Protein Alignment Ret and Csk

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 775
• Identity: 194/775 - (25%)
• Similarity: 294/775 - (37%)
• Gaps: 229/775 - (29%)

  Fly   369 SATANVCYHINLSKLHESEQEL-PQALPLRARQHRIFESEEFN------GDSAGRSLSPPTVDYD 426
            ||...|..|  ..:|.:|:..: |.::|.....||     |.|      |.:|...||...::..
  Fly   412 SAVGAVLLH--QQQLSQSQPHIVPPSIPPHHHHHR-----ENNVHPIQAGAAAALHLSSHALNSH 469

  Fly   427 KDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPET 491
            ..:    |:|||.....|                          :.|.......|.|..::..:.
  Fly   470 NLI----SSASNHSPKSP--------------------------SQTQQQQQTTNQQQQQQQQQA 504

  Fly   492 IYFLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGG 556
            .:.:..|:.....::.|:......|.|    |:..:...::.|....::..:.|      ..||.
  Fly   505 SHSILSTFAPAPTVAAVQPAGSQSVAG----TAAAVAAVAQQQQQQHLQLLANC------PPGGA 559

  Fly   557 SCQWRGSNSAMFGTRYGSCVPESRYCP---------DHVCDPLEELNPMACPQDCTPAGRIVGP- 611
            .......|:|..| .:|:    .|..|         .|..:.|....|.. ||...||. :||.
  Fly   560 GLMSSSLNAAQMG-MHGA----ERALPPKSLALSGSQHGSNMLLHTAPQP-PQASQPAA-VVGVS 617

  Fly   612 -----------HSSNENKRGIYSASG----------------------TCICEDNGKCSC----- 638
                       ||.:.|  |:.:.||                      |.:....|:..|
  Fly   618 GSGSAGMSTSLHSFDIN--GVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLN 680

  Fly   639 --------APLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQP--------------------L 675
                    ...||...:.:||:       :.|..||..|  |.|                    |
  Fly   681 AMPWFHGSITRDEAEHLLQPRE-------DGLFLVREST--NFPGDYTLCVCFQSKVEHYRVKYL 736

  Fly   676 QDPML---------LGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMT 731
            ::.:.         ||.| ||.:|.|...         |...|:.||         .:||||...
  Fly   737 ENKLTIDDEEYFENLGQL-VAHYEADADG---------LCTQLIKCL---------PKLGKQEFC 782

  Fly   732 TSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGL 796
            .:||         ||.             |..|..|..:|||...:|:||||.|:.|....
  Fly   783 INSK---------DFV-------------DKGWVIPEAELQLRESIGKGEFGDVMLGILRN---- 821

  Fly   797 PGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRS 861
               ..|||||||......:::|   |..::..:.|.|::|.:|...:|:...|:.||...|||..
  Fly   822 ---EKVAVKMLKDEGAVQKFLA---EASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVD 880

  Fly   862 YLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICK 926
            ||| ||           |.:.:..|..:.||:....||.||...|:|||||||||||:::..:.|
  Fly   881 YLR-SR-----------GRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAK 933

  Fly   927 ISDFGLTR-DVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYP 990
            :|||||.| :.|..|.      .::|:||.|||:|.:..:::|||:||||:|.||:.:.|..|||
  Fly   934 VSDFGLAREECYNLDV------GKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYP 992

  Fly   991 GIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNA 1050
            .|...::...::.||:|:.||.|...:|.::|..|...|..||:|..|..:.:.|  |||
  Fly   993 RIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLL--NNA 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/279 (36%)
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	22/124 (18%)
		PTKc_Csk_like	793..1047	CDD:270635	102/281 (36%)