Protein Alignment Ret and yes1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001013288.2
• Gene: yes1 / 407620
• ZFINID: ZDB-GENE-050126-1
• Length: 546
• Species: Danio rerio
• Alignment Length: 287
• Identity: 112/287 - (39%)
• Similarity: 166/287 - (57%)
• Gaps: 26/287 - (9%)

  Fly   760 GDAK--WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSE 822
            |.||  ||.|||.|:|:..||:|.||:|..|...      |.|.||:|.||.|:.|.|  |.|.|
Zfish   267 GLAKDAWEIPRESLRLELKLGQGCFGEVWMGTWN------GTTKVAIKTLKPGTMSPE--AFLQE 323

  Fly   823 FQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVK 886
            .|:::::.|..::.|....  ||.|:.|: ||...|||..:|:     |..|       :.:.:.
Zfish   324 AQIMKKLRHDKLVPLYAVV--SEEPIYIVTEYMGKGSLLDFLK-----EGEG-------KYLKLP 374

  Fly   887 MVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVP 951
            .::..|.||..|||::..:..:||||.|.|:|:.|..:|||:||||.| :.||:.|..|...:.|
Zfish   375 QLVDMAAQIADGMAFIERMNYIHRDLRAANILVGDNLVCKIADFGLAR-LIEDNEYTARQGAKFP 438

  Fly   952 VKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEA 1016
            :||.|||:.....:|.||||||||:|..||:|.|..||||:..:.:...::.||||..|:.|.|:
Zfish   439 IKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPES 503

  Fly  1017 VYSIVRTCWADEPNGRPSFKFLASEFE 1043
            ::.::|.||..||:.||:|:::.|..|
Zfish   504 LHEMMRLCWKKEPDERPTFEYIQSFLE 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	104/275 (38%)
yes1	NP_001013288.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58
		SH3_Yes	97..154	CDD:212940
		SH2_Src_family	157..256	CDD:199827
		PTKc_Yes	267..545	CDD:270654	112/287 (39%)