DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and btl

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:1080 Identity:261/1080 - (24%)
Similarity:412/1080 - (38%) Gaps:323/1080 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 NAGSSHFVLKQNRLYT-RQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDR 255
            |:|:...:..|||.|. ...:.|.|..|.:         |...|||                   
  Fly    84 NSGNYGCLDSQNRWYNISLVVGHKEPVGND---------IASFVKL------------------- 120

  Fly   256 NDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHA 320
             ::.|.|.||...|     ||   .:|....|::.....|::..|          .|||:.:|..
  Fly   121 -EDAPALPESDLFF-----QP---LNESRSLKLLQPLPKTVQRTA----------GGLFQLNCSP 166

  Fly   321 YEADHTGRPHTIVSCQLRFSRNGVFRETPYC-----VSLEARDLTI--VSRVDAMSATANVCYHI 378
            .:.|..|           .:.:.:..:|...     :.|:...||:  :...||.|      ||.
  Fly   167 MDPDAKG-----------VNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGS------YHC 214

  Fly   379 NLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQ 443
            .|....:.::..|..|.:.:|:|.:            ..|.|   .|.::.|:......:...:.
  Fly   215 ELCVEQDCQRSNPTQLEVISRKHTV------------PMLKP---GYPRNTSIALGDNVSIECLL 264

  Fly   444 PDSFLD--LMRLRSIRFDIVEDKL------GAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWI 500
            .||.|:  :..|.....|.::|.|      ....:..|..|..:..||||               
  Fly   265 EDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVL--------------- 314

  Fly   501 DQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNS 565
                    |:.||.:..|.......|.:|   .:|.|        ..|..|.:...:...|.:.:
  Fly   315 --------RLGNVLMEDGGWYICIAENQV---GRTVA--------ASYVDLYSPSDTTTVRTTTT 360

  Fly   566 AMFGTRYGSCVPESRYCPDH---VCDPLEE----LNP--------------------MACP---- 599
                |...|.:|.:....|:   |.:|..|    :.|                    :|||    
  Fly   361 ----TTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPVYGK 421

  Fly   600 ------QDCTPAGRIVGPH----------SSNENKRGIYSA----SGTCICED-----NGKCSCA 639
                  :|..|..|.:|.:          .:.....|:|:.    :..||..|     |.:...|
  Fly   422 ANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSA 486

  Fly   640 PLDEEPKMKKPRKRKNET---------------EAEPLLGVRRGTPPNQPL-------------- 675
            |:...|        :|:|               :..|.:..:|....|..|              
  Fly   487 PIIVVP--------QNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFT 543

  Fly   676 --QDPMLLGVLNV-------------AGFECDRSCMFFVITCPL----LFVLL------------ 709
              .|.::|.:.||             :|.....|.::..:..||    ::.||            
  Fly   544 VTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAI 608

  Fly   710 ---LLCLL-----------IAQRKMLQRRL----------------GKQSMTTSS---------- 734
               .|.||           :.:.|:|:.|:                |::....||          
  Fly   609 TIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRI 673

  Fly   735 -KQALPESGGGDFALMPLQSGFRFESG-DAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLP 797
             ||....|..|.....|.|....:|.. |:.||.||::|.|.::||||.||:|:   ..|..|||
  Fly   674 EKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVV---MAEAEGLP 735

  Fly   798 -----GITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARY 856
                 ..|.|||||:|:.....:..:|:.|.::::.: .|.|:|.|||.|:......:|:|||.:
  Fly   736 RSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPH 800

  Fly   857 GSLRSYLRLSRKIECAGVDFADG---------VEPVNVKMVLTFAWQICKGMAYLSELKLVHRDL 912
            |:|:.:|:.:|.........:||         .:.:..|.:..||:||.:||.||:..:.:||||
  Fly   801 GNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDL 865

  Fly   913 AARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVL 977
            ||||||::||.:.||:||||.||:.:.:.|.|.:..|:|:||||||||.:..|.|:|||||:|||
  Fly   866 AARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVL 930

  Fly   978 CWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASE 1041
            .||::|.|..|||.| :.:.|:|.|.||.||::|..||..:|.::|.||..|...||:|..|...
  Fly   931 LWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVES 995

  Fly  1042 FEKLL-----GNNAKYIDLETNAVSNPLYCGDDSALITTE 1076
            |:.:|     ..|..|:||....:..|...||:.....||
  Fly   996 FDGILQQASSNPNDAYLDLSMPMLETPPSSGDEDDGSDTE 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 119/299 (40%)
btlNP_729956.1 Ig 143..215 CDD:472250 18/98 (18%)
Ig strand B 160..164 CDD:409570 1/3 (33%)
Ig strand C 175..179 CDD:409570 0/3 (0%)
Ig strand E 197..201 CDD:409570 1/3 (33%)
Ig strand F 211..215 CDD:409570 3/9 (33%)
Ig_3 247..333 CDD:464046 18/108 (17%)
Ig 398..479 CDD:472250 12/80 (15%)
Ig strand B 412..416 CDD:409393 0/3 (0%)
Ig strand C 423..427 CDD:409393 0/3 (0%)
Ig strand E 445..449 CDD:409393 0/3 (0%)
Ig strand F 459..464 CDD:409393 1/4 (25%)
Ig strand G 472..475 CDD:409393 0/2 (0%)
IG_like 492..583 CDD:214653 13/98 (13%)
Ig strand B 503..507 CDD:409444 0/3 (0%)
Ig strand C 516..520 CDD:409444 0/3 (0%)
Ig strand E 549..553 CDD:409444 1/3 (33%)
Ig strand F 563..568 CDD:409444 0/4 (0%)
Ig strand G 576..579 CDD:409444 1/2 (50%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 123/302 (41%)

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