DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and LCK

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_001426075.1 Gene:LCK / 3932 HGNCID:6524 Length:567 Species:Homo sapiens


Alignment Length:282 Identity:114/282 - (40%)
Similarity:165/282 - (58%) Gaps:24/282 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            :||.|||.|:|...||.|:||:|..|:..      |.|.||||.||:||.|.:  |.|:|..|::
Human   295 EWEVPRETLKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQGSMSPD--AFLAEANLMK 351

  Fly   828 EVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTF 891
            ::.|..:::|....|  :.|:.|| ||...|||..:|:....|:            :.:..:|..
Human   352 QLQHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTPSGIK------------LTINKLLDM 402

  Fly   892 AWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMA 956
            |.||.:|||::.|...:||||.|.|:|::|...|||:||||.| :.||:.|..|...:.|:||.|
Human   403 AAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLAR-LIEDNEYTAREGAKFPIKWTA 466

  Fly   957 PESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIV 1021
            ||::....:|.||||||||:|..|::|.|..||||:....:...|:.||||.||:||.|.:|.::
Human   467 PEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 531

  Fly  1022 RTCWADEPNGRPSFKFLASEFE 1043
            |.||.:.|..||:|.:|.|..|
Human   532 RLCWKERPEDRPTFDYLRSVLE 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 109/275 (40%)
LCKNP_001426075.1 None

Return to query results.
Submit another query.