DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and pdgfra

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_571534.1 Gene:pdgfra / 386856 ZFINID:ZDB-GENE-990415-208 Length:1059 Species:Danio rerio


Alignment Length:580 Identity:168/580 - (28%)
Similarity:262/580 - (45%) Gaps:144/580 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   704 LLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPES---GGGDFALM-PLQSGFRFESGDAKW 764
            |:.|::.|.:|:.        :.||......:..:.||   .|.::..: |:|..:     |::|
Zfish   510 LVIVIISLIVLVI--------IWKQKPRYEIRWRVIESVSPDGHEYIYVDPMQLPY-----DSRW 561

  Fly   765 EFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV 829
            ||||:.|.|..|||.|.||:|::|.|..::....:..|||||||..:.|.|..||:||.:::..:
Zfish   562 EFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHL 626

  Fly   830 S-HPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSR-------------KIECAGVDFA--- 877
            . |.|::.||||||.|....:|.||..||.|.:||..:|             .::..|::.|   
Zfish   627 GPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDGFLSRHTEKGKKDLDIFGINPADES 691

  Fly   878 ----------------------------------------------------------------- 877
                                                                             
Zfish   692 SRSYVILSLEGKGDYMDMKQADTMQYVPMLEMNEASKYSPIQRSDYDHPPSHRQFNDEAESLLSD 756

  Fly   878 DGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAY 942
            |..|.:....:|:|.:|:.:||.:|:....||||||||||||:.|||.||.||||.||:..|:.|
Zfish   757 DSAEGLTTMDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLSQGKIVKICDFGLARDIMHDNNY 821

  Fly   943 LKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPG-IAPQNLWSLLKTGYR 1006
            :.:....:|||||||||:.|::||:.|||||:|:|.||:.:||.:|||| :...:.::.:|:|||
Zfish   822 VSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMVVDSSFYNKIKSGYR 886

  Fly  1007 MDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGN---------NAKYIDLETNAVSN 1062
            |.:||:.|..||.::..||..||..||||..|:.....||.:         |..::..:..||:.
Zfish   887 MTKPEHASSDVYELMMKCWNSEPEKRPSFHSLSDTVASLLPSGFKRCYERVNHDFLKSDHPAVTR 951

  Fly  1063 PLYCGDDSALITTELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLL 1127
            .....:|.|.:                 .:.|....:..:.:...:|..::|.:  ||.:|.|.|
Zfish   952 VQCIDNDDAYM-----------------GVLYKNQGKMKTRESGFDEQRLSSDS--GYIIPLPDL 997

  Fly  1128 DATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKRGRSYLDMT 1187
            |                ||:....|....:|:.|||..|..:....|...:.|.:..|:|
Zfish   998 D----------------PLSNEDYSKRNRHSSQTSEESAIDTGSSSSTTKREGETLEDIT 1041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 125/370 (34%)
TyrKc 771..1042 CDD:197581 123/353 (35%)
pdgfraNP_571534.1 IG_like 19..94 CDD:214653
IG_like 199..283 CDD:214653
Ig 203..285 CDD:299845
Ig 288..387 CDD:299845
Ig 389..491 CDD:299845
PKc_like 530..928 CDD:304357 136/402 (34%)
Pkinase_Tyr 568..918 CDD:285015 122/349 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 975..1036 18/78 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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