Protein Alignment Ret and Lmtk3

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_030098591.1
• Gene: Lmtk3 / 381983
• MGIID: 3039582
• Length: 1451
• Species: Mus musculus
• Alignment Length: 578
• Identity: 141/578 - (24%)
• Similarity: 222/578 - (38%)
• Gaps: 148/578 - (25%)

  Fly   674 PLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQR-----KMLQRRLGKQ----- 728
            ||..|..:.:::.:|.              |.|:.|||..|..:|     |..:...|:.
Mouse    61 PLAPPYAVVLISCSGL--------------LAFIFLLLTCLCCKRGDVRFKEFENPEGEDCSGEY 111

  Fly   729 ---SMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFP------------------REKLQ 772
               :..|||.|:||     |..::||          |:...|                  |:.|.
Mouse   112 TPPAEETSSSQSLP-----DVYILPL----------AEVSLPMPAPQPPHSDISTPLGLSRQHLS 161

  Fly   773 LDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKL 837
            ....:|.|.||:|:.|   |:........|.||.|:..:..:|....:||.|..:.:.||||::.
Mouse   162 YLQEIGSGWFGKVILG---EVFSDYSPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQC 223

  Fly   838 LGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYL 902
            ||.|..:...|||:|:.:.|.|:.|||..|..|    ..:..:.|.:::.:.....:|.:|:|:|
Mouse   224 LGVCVETLPFLLIMEFCQLGDLKRYLRAQRPPE----GMSPELPPRDLRTLQRMGLEIARGLAHL 284

  Fly   903 SELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLAD-H--- 963
            .....||.|||.||.||......:|.|:||....|::|.||...|..||::|.|||.|.: |
Mouse   285 HSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWVPLRWAAPELLGELHGSF 349

  Fly   964 ---VYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLL--KTGYRMDRPE---NCSEAVYSI 1020
               ..:.:|:|||.||..|||...||.||..::.:.:.:.:  :...::.||.   ..::..|.|
Mouse   350 VLVDQSRESNVWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDI 414

  Fly  1021 VRTCWADEPNGRPSFKFLASEFEKLLGNN---------------------AKYIDLETNAVSN-- 1062
            :::||. .|..|||...|..:...||...                     ..:.......:|:
Mouse   415 LQSCWR-PPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPSHSAPRPGTLSSQF 478

  Fly  1063 PLYCG-----DDSALITTELGEPESLQHLW------------SPPKIAYDIHDQATSYDQSEEEM 1110
            ||..|     .|..|..||.....:|:.||            :||                  ..
Mouse   479 PLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPP------------------WQ 525

  Fly  1111 PVTSTAPPGYDLPRPLLDATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSE---PP 1165
            |.::...|..:...|..:|.:...||..       ::.|..|.:..|.....|   ||
Mouse   526 PASAPPAPHTNPSNPFYEALSTPSVLPV-------ISARSPSVSSEYYIRLEEHGSPP 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	91/290 (31%)
Lmtk3	XP_030098591.1	Protein Kinases, catalytic domain	162..437	CDD:473864	88/282 (31%)