DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and KIT

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001372213.1	Gene:	KIT / 3815	HGNCID:	6342	Length:	977	Species:	Homo sapiens

Alignment Length:	1035	Identity:	262/1035 - (25%)
Similarity:	395/1035 - (38%)	Gaps:	319/1035 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 YTIAESHGPYRRKDF-FEP-----VLIGALNSRAAKYLCPHVSLEY-SLNAGSSHFVLKQNRLYT 207
            |::....|....||. |.|     ::|.:: .||...||.|.|::. ..:..|..|:||....:.
Human   146 YSLKGCQGKPLPKDLRFIPDPKAGIMIKSV-KRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFK 209

  Fly   208 RQTLDHDELNGLNAKAGQLQARITCTVK-LSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKF-- 269
            ...:..........:.|: :..:|||:| :||.....:.|        .|....||||..:.:
Human   210 AVPVVSVSKASYLLREGE-EFTVTCTIKDVSSSVYSTWKR--------ENSQQTKLQEKYNSWHH 265

  Fly   270 -DFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRPHTIV 333
             ||..|:                     :|...:..|..||| |:|.  |:|
Human   266 GDFNYER---------------------QATLTISSARVNDS-GVFM--CYA------------- 293

  Fly   334 SCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRA 398
                    |..|.......:||..|...::....::.|..|....|:..:.|.|     |.|...
Human   294 --------NNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYE-----AFPKPE 345

  Fly   399 RQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVED 463
            .|..|:         ..|:.:....||.|..:     .||.|.|   |.|.|.||:
Human   346 HQQWIY---------MNRTFTDKWEDYPKSEN-----ESNIRYV---SELHLTRLK--------- 384

  Fly   464 KLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELK 528
              |..|.|.|   ..|.|..|.......:| :|.   ..:.|::.|::|..|
Human   385 --GTEGGTYT---FLVSNSDVNAAIAFNVY-VNT---KPEILTYDRLVNGML------------- 427

  Fly   529 VKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESR----YCP--DHVC 587
                           |||     |.|                     .||..    :||  :..|
Human   428 ---------------QCV-----AAG---------------------FPEPTIDWYFCPGTEQRC 451

  Fly   588 D------PLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICE---DNGKCSCAPLDE 643
            .      .::.||...     .|.|::|...|.:.:   .:..:||..|:   |.||.|.
Human   452 SASVLPVDVQTLNSSG-----PPFGKLVVQSSIDSS---AFKHNGTVECKAYNDVGKTSA----- 503

  Fly   644 EPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVL 708
              ......|..|:.:..|           ..|..|:|:|.:.|||..|
Human   504 --YFNFAFKGNNKEQIHP-----------HTLFTPLLIGFVIVAGMMC----------------- 538

  Fly   709 LLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALM-PLQSGFRFESGDAKWEFPREKLQ 772
              :.::|...|.||:     .|.....:.:.|..|.::..: |.|..:     |.||||||.:|.
Human   539 --IIVMILTYKYLQK-----PMYEVQWKVVEEINGNNYVYIDPTQLPY-----DHKWEFPRNRLS 591

  Fly   773 LDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIK 836
            ....||.|.||:|::..|..:.......||||||||..::..|..||:||.::|..: :|.|::.
Human   592 FGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVN 656

  Fly   837 LLGACTSSEAPLLIIEYARYGSLRSYLRL------------------------SRKIECAG---- 873
            ||||||.....|:|.||..||.|.::||.                        |::..|:.
Human   657 LLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE 721

  Fly   874 -VDFADGVEPV---------------------------------NVKMVLTFAWQICKGMAYLSE 904
             :|...||..|                                 :::.:|:|::|:.||||:|:.
Human   722 YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLAS 786

  Fly   905 LKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKS 969
            ...:||||||||:||..|:|.||.||||.||:..|..|:.:...|:|||||||||:.:.|||.:|
Human   787 KNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFES 851

  Fly   970 DVWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRP 1033
            ||||:|:..|||.:||:|||||: .....:.::|.|:||..||:....:|.|::|||..:|..||
Human   852 DVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRP 916

  Fly  1034 SFKFLASEFEKLLGNNAKYI------------------DLETNAV------SNPLYCGDD 1069
            :||.:....||.:..:..:|                  .:..|:|      |.||...||
Human   917 TFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	122/342 (36%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	120/334 (36%)
KIT	NP_001372213.1	Ig strand A	212..215	CDD:409353	0/2 (0%)
		ig	216..306	CDD:395002	27/143 (19%)
		Ig strand B	229..239	CDD:409353	4/9 (44%)
		Ig strand C'	250..252	CDD:409353	1/1 (100%)
		Ig strand D	260..263	CDD:409353	0/2 (0%)
		Ig strand E	267..280	CDD:409353	4/33 (12%)
		Ig strand F	287..294	CDD:409353	4/29 (14%)
		Ig strand G	300..308	CDD:409353	1/7 (14%)
		IgI_4_SCFR	312..412	CDD:409446	30/136 (22%)
		Ig strand B	332..336	CDD:409446	0/3 (0%)
		Ig strand C	346..350	CDD:409446	1/3 (33%)
		Ig strand E	376..380	CDD:409446	2/3 (67%)
		Ig strand F	390..395	CDD:409446	2/7 (29%)
		Ig strand G	403..406	CDD:409446	0/2 (0%)
		Ig	427..503	CDD:409353	23/137 (17%)
		Ig strand C	438..442	CDD:409353	0/3 (0%)
		Ig strand E	471..479	CDD:409353	2/7 (29%)
		Ig strand F	489..494	CDD:409353	2/4 (50%)
		PTKc_Kit	554..929	CDD:270682	133/379 (35%)
		Important for interaction with phosphotyrosine-binding proteins	569..571		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910