DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and KDR

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:1354 Identity:321/1354 - (23%)
Similarity:523/1354 - (38%) Gaps:376/1354 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 INEESESIFSK---IP------LAQFQVLRMEDNRLASDYLYSLE-QNPLL-RINSSSGEIYMRT 92
            :.|.|:.:|.|   ||      ...::....|.:..:..|:|..: ::|.: .::...|.:|:  
Human    76 VTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYI-- 138

  Fly    93 DYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQ-PLEEYCSELEHICFWSSAQYTIAESH 156
               :.|.:.|.::..         |.::|:|::.:..: |.:.:..:...|.:.|...:||....
Human   139 ---TENKNKTVVIPC---------LGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYM 191

  Fly   157 GPYRRKDFFEPVLIGALNSRAAKYLCPHVSLE-YSLNAGSSHFVLKQNRLYTRQTLDHDELNGLN 220
            ..|....|.| ..|...:.::..|:...|... |.:....||                    |:.
Human   192 ISYAGMVFCE-AKINDESYQSIMYIVVVVGYRIYDVVLSPSH--------------------GIE 235

  Fly   221 AKAGQLQARITCTV----------------------KLSSRD--------QRKFSRILDIKLLDR 255
            ...|: :..:.||.                      ||.:||        .:||...|.|..:.|
Human   236 LSVGE-KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTR 299

  Fly   256 NDNG--------PKLQESSSKFDFYLEQPY--FQADEEAGKKVIYVDKDTLEANAHLVYAVHNDS 310
            :|.|        ..:.:.:|.|....|:|:  |.:..|:..:....::..:.|. :|.|.     
Human   300 SDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAK-YLGYP----- 358

  Fly   311 HGLFRPDCHAY------EADHT---GRPHTIVSCQLRFSRN-GVFRETP-------YCVSL---- 354
                .|:...|      |::||   |...||:....|.:.| .|....|       :.|||    
Human   359 ----PPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYV 419

  Fly   355 --EARDLTIVSRVDA------MSATANVC-----YHINLSKLHESE--QELPQAL----PLRARQ 400
              :..:.:::|.||:      .:.|..|.     :||:.....|.|  .|..||:    |....:
Human   420 PPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEE 484

  Fly   401 HRIFESEEFNGDSAGRSLSPPTVDY------DKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFD 459
            .|  ..|:|.|   |..:......:      :|.||..        |:|..:...|.:..::   
Human   485 WR--SVEDFQG---GNKIEVNKNQFALIEGKNKTVSTL--------VIQAANVSALYKCEAV--- 533

  Fly   460 IVEDKLG------AFGITSTSGIVFVKNPQVLEEAPETIY-------FLNVTW--IDQQRLS-HV 508
               :|:|      :|.:|....|....:.|..|:...:::       |.|:||  :..|.|. ||
Human   534 ---NKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHV 595

  Fly   509 RVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYG 573
            ..:...:.  :..:|..:|.....|.:...|..         :.....|.|.:|....:...|  
Human   596 GELPTPVC--KNLDTLWKLNATMFSNSTNDILI---------MELKNASLQDQGDYVCLAQDR-- 647

  Fly   574 SCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSC 638
              ..:.|:|.......||.:.|       |..|.:       ||:......|....|..:|    
Human   648 --KTKKRHCVVRQLTVLERVAP-------TITGNL-------ENQTTSIGESIEVSCTASG---- 692

  Fly   639 APLDEEPKMKKPRKRKNETEAEPL----------LGVRRGTPPNQPLQDPMLLGVLNVAGFECDR 693
                 .|..:....:.|||..|..          |.:||....::.|.......||..|..|.  
Human   693 -----NPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEA-- 750

  Fly   694 SCMFFVI------------------TCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPE 740
               ||:|                  ...:.|.|||:.:|                     :.:..
Human   751 ---FFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIIL---------------------RTVKR 791

  Fly   741 SGGGDFALMPLQSGF-----------------RFESGDAKWEFPREKLQLDTVLGEGEFGQVLKG 788
            :.||:     |::|:                 |.....:||||||::|:|...||.|.||||::.
Human   792 ANGGE-----LKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEA 851

  Fly   789 FATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHP-NVIKLLGACTSSEAPLL-II 851
            .|..|.......||||||||:|:...|:.||:||.::|..:.|. ||:.||||||....||: |:
Human   852 DAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIV 916

  Fly   852 EYARYGSLRSYLRLSRK----IECAGVDFADGVE-----PVNVKM-------------------- 887
            |:.::|:|.:|||..|.    .:..|..|..|.:     ||::|.                    
Human   917 EFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEK 981

  Fly   888 -----------------------VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISD 929
                                   ::.:::|:.|||.:|:..|.:||||||||:||::..:.||.|
Human   982 SLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICD 1046

  Fly   930 FGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-A 993
            |||.||:|:|..|:::...|:|:||||||::.|.|||.:|||||||||.||:.:||||||||: .
Human  1047 FGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKI 1111

  Fly   994 PQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK-----YI 1053
            .:.....||.|.||..|:..:..:|..:..||..||:.||:|..|......||..||:     ||
Human  1112 DEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYI 1176

  Fly  1054 DLETNAVSNPLYCGDDS--ALITTELG--EPESLQHLWSPPKIAYDIHDQATSYDQS--EEEMPV 1112
            .|   .:|..|...:||  :|.|:.:.  |.|.:    ..||..||.....:.|.|:  .:..||
Human  1177 VL---PISETLSMEEDSGLSLPTSPVSCMEEEEV----CDPKFHYDNTAGISQYLQNSKRKSRPV 1234

  Fly  1113 TSTAPPGYDLPRPLL------DATANGQVLRYENDLRFPLNIRKSSCTPSYSNM 1160
            :........|..|.:      :.|.:|.||..| :|: .|..| :..:||:..|
Human  1235 SVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASE-ELK-TLEDR-TKLSPSFGGM 1285

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 126/333 (38%)
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448 20/122 (16%)
Ig strand A 224..228 CDD:409448 1/3 (33%)
Ig strand A' 234..238 CDD:409448 0/3 (0%)
Ig strand B 240..249 CDD:409448 2/9 (22%)
Ig strand C 256..261 CDD:409448 0/4 (0%)
Ig strand C' 264..266 CDD:409448 0/1 (0%)
Ig strand D 270..278 CDD:409448 4/7 (57%)
Ig strand E 286..294 CDD:409448 3/7 (43%)
Ig strand F 304..310 CDD:409448 0/5 (0%)
Ig strand G 315..321 CDD:409448 1/5 (20%)
IgI_VEGFR-2 329..417 CDD:409450 20/97 (21%)
Ig strand A 329..332 CDD:409450 0/2 (0%)
Ig strand A' 339..343 CDD:409450 0/3 (0%)
Ig strand B 345..356 CDD:409450 1/11 (9%)
Ig strand C 360..366 CDD:409450 1/5 (20%)
Ig strand C' 368..371 CDD:409450 0/2 (0%)
Ig strand D 376..379 CDD:409450 1/2 (50%)
Ig strand E 381..386 CDD:409450 1/4 (25%)
Ig strand F 394..402 CDD:409450 2/7 (29%)
Ig strand G 408..417 CDD:409450 3/8 (38%)
IG_like 565..661 CDD:214653 18/110 (16%)
I-set 667..754 CDD:400151 23/114 (20%)
Ig strand B 684..688 CDD:409353 0/3 (0%)
Ig strand C 697..701 CDD:409353 0/3 (0%)
Ig strand E 720..724 CDD:409353 1/3 (33%)
Ig strand F 734..739 CDD:409353 1/4 (25%)
VEGFR-2_TMD 759..793 CDD:375470 5/54 (9%)
PTKc_VEGFR2 826..1167 CDD:270681 132/340 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318 4/13 (31%)

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