DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and KDR

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:1354 Identity:321/1354 - (23%)
Similarity:523/1354 - (38%) Gaps:376/1354 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 INEESESIFSK---IP------LAQFQVLRMEDNRLASDYLYSLE-QNPLL-RINSSSGEIYMRT 92
            :.|.|:.:|.|   ||      ...::....|.:..:..|:|..: ::|.: .::...|.:|:  
Human    76 VTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYI-- 138

  Fly    93 DYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQ-PLEEYCSELEHICFWSSAQYTIAESH 156
               :.|.:.|.::..         |.::|:|::.:..: |.:.:..:...|.:.|...:||....
Human   139 ---TENKNKTVVIPC---------LGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYM 191

  Fly   157 GPYRRKDFFEPVLIGALNSRAAKYLCPHVSLE-YSLNAGSSHFVLKQNRLYTRQTLDHDELNGLN 220
            ..|....|.| ..|...:.::..|:...|... |.:....||                    |:.
Human   192 ISYAGMVFCE-AKINDESYQSIMYIVVVVGYRIYDVVLSPSH--------------------GIE 235

  Fly   221 AKAGQLQARITCTV----------------------KLSSRD--------QRKFSRILDIKLLDR 255
            ...|: :..:.||.                      ||.:||        .:||...|.|..:.|
Human   236 LSVGE-KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTR 299

  Fly   256 NDNG--------PKLQESSSKFDFYLEQPY--FQADEEAGKKVIYVDKDTLEANAHLVYAVHNDS 310
            :|.|        ..:.:.:|.|....|:|:  |.:..|:..:....::..:.|. :|.|.     
Human   300 SDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAK-YLGYP----- 358

  Fly   311 HGLFRPDCHAY------EADHT---GRPHTIVSCQLRFSRN-GVFRETP-------YCVSL---- 354
                .|:...|      |::||   |...||:....|.:.| .|....|       :.|||    
Human   359 ----PPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYV 419

  Fly   355 --EARDLTIVSRVDA------MSATANVC-----YHINLSKLHESE--QELPQAL----PLRARQ 400
              :..:.:::|.||:      .:.|..|.     :||:.....|.|  .|..||:    |....:
Human   420 PPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEE 484

  Fly   401 HRIFESEEFNGDSAGRSLSPPTVDY------DKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFD 459
            .|  ..|:|.|   |..:......:      :|.||..        |:|..:...|.:..::   
Human   485 WR--SVEDFQG---GNKIEVNKNQFALIEGKNKTVSTL--------VIQAANVSALYKCEAV--- 533

  Fly   460 IVEDKLG------AFGITSTSGIVFVKNPQVLEEAPETIY-------FLNVTW--IDQQRLS-HV 508
               :|:|      :|.:|....|....:.|..|:...:::       |.|:||  :..|.|. ||
Human   534 ---NKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHV 595

  Fly   509 RVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYG 573
            ..:...:.  :..:|..:|.....|.:...|..         :.....|.|.:|....:...|  
Human   596 GELPTPVC--KNLDTLWKLNATMFSNSTNDILI---------MELKNASLQDQGDYVCLAQDR-- 647

  Fly   574 SCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSC 638
              ..:.|:|.......||.:.|       |..|.:       ||:......|....|..:|    
Human   648 --KTKKRHCVVRQLTVLERVAP-------TITGNL-------ENQTTSIGESIEVSCTASG---- 692

  Fly   639 APLDEEPKMKKPRKRKNETEAEPL----------LGVRRGTPPNQPLQDPMLLGVLNVAGFECDR 693
                 .|..:....:.|||..|..          |.:||....::.|.......||..|..|.  
Human   693 -----NPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEA-- 750

  Fly   694 SCMFFVI------------------TCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPE 740
               ||:|                  ...:.|.|||:.:|                     :.:..
Human   751 ---FFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIIL---------------------RTVKR 791

  Fly   741 SGGGDFALMPLQSGF-----------------RFESGDAKWEFPREKLQLDTVLGEGEFGQVLKG 788
            :.||:     |::|:                 |.....:||||||::|:|...||.|.||||::.
Human   792 ANGGE-----LKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEA 851

  Fly   789 FATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHP-NVIKLLGACTSSEAPLL-II 851
            .|..|.......||||||||:|:...|:.||:||.::|..:.|. ||:.||||||....||: |:
Human   852 DAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIV 916

  Fly   852 EYARYGSLRSYLRLSRK----IECAGVDFADGVE-----PVNVKM-------------------- 887
            |:.::|:|.:|||..|.    .:..|..|..|.:     ||::|.                    
Human   917 EFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEK 981

  Fly   888 -----------------------VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISD 929
                                   ::.:::|:.|||.:|:..|.:||||||||:||::..:.||.|
Human   982 SLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICD 1046

  Fly   930 FGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-A 993
            |||.||:|:|..|:::...|:|:||||||::.|.|||.:|||||||||.||:.:||||||||: .
Human  1047 FGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKI 1111

  Fly   994 PQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK-----YI 1053
            .:.....||.|.||..|:..:..:|..:..||..||:.||:|..|......||..||:     ||
Human  1112 DEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYI 1176

  Fly  1054 DLETNAVSNPLYCGDDS--ALITTELG--EPESLQHLWSPPKIAYDIHDQATSYDQS--EEEMPV 1112
            .|   .:|..|...:||  :|.|:.:.  |.|.:    ..||..||.....:.|.|:  .:..||
Human  1177 VL---PISETLSMEEDSGLSLPTSPVSCMEEEEV----CDPKFHYDNTAGISQYLQNSKRKSRPV 1234

  Fly  1113 TSTAPPGYDLPRPLL------DATANGQVLRYENDLRFPLNIRKSSCTPSYSNM 1160
            :........|..|.:      :.|.:|.||..| :|: .|..| :..:||:..|
Human  1235 SVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASE-ELK-TLEDR-TKLSPSFGGM 1285

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 126/333 (38%)
TyrKc 771..1042 CDD:197581 124/325 (38%)
KDRNP_002244.1 Ig 41..109 CDD:299845 7/32 (22%)
IG_like 231..324 CDD:214653 19/113 (17%)
Ig1_VEGFR 239..326 CDD:143270 16/87 (18%)
IG_like 340..417 CDD:214653 18/86 (21%)
Ig2_VEGFR-2 348..417 CDD:143272 18/78 (23%)
Ig_2 551..661 CDD:290606 21/124 (17%)
IG 565..661 CDD:214652 18/110 (16%)
I-set 667..754 CDD:254352 23/114 (20%)
IGc2 680..744 CDD:197706 13/72 (18%)
PTKc_VEGFR2 826..1167 CDD:270681 132/340 (39%)
Pkinase_Tyr 834..1160 CDD:285015 124/325 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318 4/13 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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