DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and Egfr

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster


Alignment Length:1478 Identity:304/1478 - (20%)
Similarity:496/1478 - (33%) Gaps:516/1478 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 HCAAVDVYFPTTSV-----KFNMPINEESESIFSKIPLAQFQVLRMEDNRLASDYLYSLEQNPLL 79
            |.....|.||...:     .|::.:.||..::|  :..::...|.:.|.|...:.......|..|
  Fly   165 HVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALF--VTYSKMYTLEIPDLRDVLNGQVGFHNNYNL 227

  Fly    80 ---------RINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPD-HELLNVSH------------ 122
                     .|.|:..:.|...|:.:|.           |:.|. ||  :.:|            
  Fly   228 CHMRTIQWSEIVSNGTDAYYNYDFTAPE-----------RECPKCHE--SCTHGCWGEGPKNCQK 279

  Fly   123 -LSLEVTPQ--------PLEEYCSELEHICFWSSAQYTIAESHGPYRR-----KDFFEPVLIGAL 173
             ..|..:||        |....|..|          :......||.::     |:||:       
  Fly   280 FSKLTCSPQCAGGRCYGPKPRECCHL----------FCAGGCTGPTQKDCIACKNFFD------- 327

  Fly   174 NSRAAKYLCPHVS--------LE------YSLNAG-----SSHFVLKQNRLYTRQTLDHDEL--- 216
             ....|..||.:.        ||      |:..|.     ..| :|:.|....| :...|::   
  Fly   328 -EGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGH-LLRDNGACVR-SCPQDKMDKG 389

  Fly   217 ------NGLNAK---------AGQLQARITCTVKLSSRDQRKFSRILD--IKLLDRNDNGPKLQE 264
                  ||...|         ||.:.:...|||             :|  |::||:..:|.:   
  Fly   390 GECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTV-------------IDGNIRILDQTFSGFQ--- 438

  Fly   265 SSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRP 329
                 |.|       |:...|.:.|.:|.:.||     |::...:..|...     .|..|.   
  Fly   439 -----DVY-------ANYTMGPRYIPLDPERLE-----VFSTVKEITGYLN-----IEGTHP--- 478

  Fly   330 HTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQAL 394
                  |.|                                  |:.|..||..:|          
  Fly   479 ------QFR----------------------------------NLSYFRNLETIH---------- 493

  Fly   395 PLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSF-LDLMRLRSIRF 458
                                ||.|..         |::.:.|    :|:...: |::..|:.|  
  Fly   494 --------------------GRQLME---------SMFAALA----IVKSSLYSLEMRNLKQI-- 523

  Fly   459 DIVEDKLGAFGITSTSGIVFVKN---PQVLEEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRP 520
                 ..|:..|.....:.:|.|   |.:.:|..:.:      |:::...:.:...|..:...:.
  Fly   524 -----SSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKV------WVNENLRADLCEKNGTICSDQC 577

  Fly   521 ENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGS-CVPESRYC-- 582
            ....|......:..||....:...|:..||..          ||:..|..|... |.||.|.|  
  Fly   578 NEDGCWGAGTDQCLTCKNFNFNGTCIADCGYI----------SNAYKFDNRTCKICHPECRTCNG 632

  Fly   583 --PDHVCDPLEELNP-----MACPQD-----------------CTPAGRIVGPHSSNENKRGIYS 623
              .|| |.....:..     ..||::                 ||.....:|..:.......|.:
  Fly   633 AGADH-CQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIIN 696

  Fly   624 ASGT---CICEDNGKC---------------------------SCAPLDE--------EPKMKK- 649
            ...|   |:.:|: ||                           .|.||.|        |....| 
  Fly   697 NDATVKRCLLKDD-KCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKC 760

  Fly   650 ---PRKRKNETE----------------------------AEPLLGVRRGTPPNQPLQDPMLLG- 682
               .|:.:.|||                            |:.....|     |..|.|....| 
  Fly   761 THYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCR-----NFKLFDANETGP 820

  Fly   683 VLNVAGFECDRSC-----------------------------------MFFVIT----CPLLFVL 708
            .:|...|.|...|                                   |.|:||    .|.:.:|
  Fly   821 YVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICIL 885

  Fly   709 LLLCLLIAQRKMLQRRLGKQSMTTS----SKQALPESGGGDFALMPLQSGFRFESGDAKWEFPRE 769
            .::..:..|::..::...|.:|..|    |:...|.:.|.:...:.:........|.        
  Fly   886 CVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGG-------- 942

  Fly   770 KLQLDTVLGEGEFGQVLKGF---ATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSH 831
                  |||.|.||:|.||.   ..|...:|    ||:|.|.|.:.:......|.|..::..|.|
  Fly   943 ------VLGMGAFGRVYKGVWVPEGENVKIP----VAIKELLKSTGAESSEEFLREAYIMASVEH 997

  Fly   832 PNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQIC 896
            .|::|||..|.||:. :||.:....|.|..|:|.:|             :.:..|.:|.::.||.
  Fly   998 VNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNR-------------DKIGSKALLNWSTQIA 1048

  Fly   897 KGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLA 961
            |||:||.|.:||||||||||||:....:.||:||||.:.:..|....|.:..::|:||:|.|.:.
  Fly  1049 KGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIR 1113

  Fly   962 DHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWA 1026
            :.|:|||||||:|||..|||:|.|..|:..|..:::..|::.|.::::||.||..:|..:.:||.
  Fly  1114 NRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWH 1178

  Fly  1027 DEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSN-PLYCG-DDSALI-----TTE----LGEP 1080
            .:...||:||.|.:.|.:...:..:|:.:..:..:. |.|.. |:..||     ||:    :.||
  Fly  1179 LDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEP 1243

  Fly  1081 ES-LQHLWSP-PKIAYDIHDQ----------------ATSYDQSEEEMPVTSTAPPGYDLPRPLL 1127
            :. ||...:| |....|..|:                :|..|:::.............|||   :
  Fly  1244 DDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLP---V 1305

  Fly  1128 DATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTS-EPPATTSLPHYSVPVKRGRSYLDMTNKSL 1191
            |          |:|...|      :|.|..:|..: ..|...::.  :|.|..|  |:|:..   
  Fly  1306 D----------EDDYLMP------TCQPGPNNNNNINNPNQNNMA--AVGVAAG--YMDLIG--- 1347

  Fly  1192 IPDNLDSREF----------EKHL-SKTISFRFSSLLNLSETKEVSPG 1228
            :|.::|:.|:          |..: ::||......:....|.|...||
  Fly  1348 VPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGVPGTMEVKVPMPG 1395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 102/281 (36%)
TyrKc 771..1042 CDD:197581 101/273 (37%)
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 41/258 (16%)
GF_recep_IV 572..684 CDD:291509 22/122 (18%)
FU 573..>606 CDD:238021 4/32 (13%)
FU 617..659 CDD:214589 11/42 (26%)
FU 662..716 CDD:214589 9/54 (17%)
FU 739..786 CDD:238021 10/46 (22%)
FU 784..834 CDD:214589 9/54 (17%)
PTKc_EGFR_like 930..1208 CDD:270648 104/309 (34%)
STYKc 938..1194 CDD:214568 102/287 (36%)
Recep_L_domain 128..239 CDD:279382 13/75 (17%)
Furin-like 253..401 CDD:279142 31/180 (17%)
FU 255..292 CDD:214589 8/49 (16%)
FU 302..345 CDD:238021 10/60 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455297
Domainoid 1 1.000 165 1.000 Domainoid score I1208
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.940

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