Protein Alignment Ret and fyna

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001315092.1
• Gene: fyna / 373872
• ZFINID: ZDB-GENE-030903-5
• Length: 537
• Species: Danio rerio
• Alignment Length: 298
• Identity: 111/298 - (37%)
• Similarity: 168/298 - (56%)
• Gaps: 29/298 - (9%)

  Fly   749 MPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNS 813
            ||..:....::.|. ||.|||.|||...||.|:||:|..|...      |.|.||||.||.|:.|
Zfish   250 MPRLADLSVKTKDV-WEIPRESLQLIKRLGNGQFGEVWMGTWN------GNTKVAVKTLKPGTMS 307

  Fly   814 VEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFA 877
            .|  :.|.|.|:::::.|..:::|....  ||.|:.|: ||...|||..:|:
Zfish   308 PE--SFLEEAQIMKKLRHDKLVQLYAVV--SEEPIYIVTEYMSKGSLLDFLK------------- 355

  Fly   878 DGVEPVNVKM--VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDD 940
            || |...:|:  ::..|.|:..||||:..:..:||||.:.|:|:.|..:|||:||||.| :.||:
Zfish   356 DG-EGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLAR-LIEDN 418

  Fly   941 AYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGY 1005
            .|..|...:.|:||.|||:.....:|.||||||||:|..||:|.|..||||:..:.:...::.||
Zfish   419 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY 483

  Fly  1006 RMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            ||..|::|..:::.::..||..:|..||:|::|.:..|
Zfish   484 RMPCPQDCPSSLHELMLQCWKRDPEERPTFEYLQAFLE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	103/277 (37%)
fyna	NP_001315092.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..34
		SH3_Fyn_Yrk	85..140	CDD:212939
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281
		PTKc_Fyn	261..534	CDD:270655	109/287 (38%)