Protein Alignment Ret and Bmx

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001102486.1
• Gene: Bmx / 367786
• RGDID: 1565643
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 926
• Identity: 212/926 - (22%)
• Similarity: 339/926 - (36%)
• Gaps: 326/926 - (35%)

  Fly   162 KDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELNGL--NAKAG 224
            |...|.:|:  ..|:..|.:.|       :|.....|||      |:.:|.:.|.:.:  .::.|
  Rat     8 KSILEELLL--KKSQQKKKMSP-------INYKERLFVL------TKTSLSYYEYDKMKRGSRKG 57

  Fly   225 QLQA-RITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKV 288
            .::. :|.|..|::..:|....|                           :.|:         ::
  Rat    58 SIEVKKIRCVEKVNLEEQTPVER---------------------------QYPF---------QI 86

  Fly   289 IYVDKDTLEANAHLVYAVHNDSHGLFRPDCH---AYEADHTGRPHTIVSCQLRFSRNGVF----- 345
            :|  ||.|    ..|||.:.:|.      |.   |.:.:..|.||.::.....|..:|.|
  Rat    87 VY--KDGL----LYVYASNEESR------CQWLKALQKEIRGNPHLLIKYHSGFFVDGKFLCCQQ 139

  Fly   346 --RETPYCVSLEA-RDLTIVSRVDAMSATANVCYHINLS-KLH------ESEQELPQALPLRARQ 400
              :..|.|...|| .||                 ||.:| :.|      |...::|:|:|:
  Rat   140 SCKAAPGCTLWEAYADL-----------------HIAISDEKHRAPTFPERILKIPRAVPI---- 183

  Fly   401 HRIFESEEFNGDSAGRSLSPPTVD------YDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFD 459
                    ...|::..|..||..|      ||...:|      |.|.:..:...|..::|..:.:
  Rat   184 --------LKMDASSSSAIPPQYDSHLKKSYDSQPTV------NIRYIPREDCPDWWQIRKPKSE 234

  Fly   460 IVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTS 524
              ||      |..::.:    ...::..:|.     .::|                  |.||::|
  Rat   235 --ED------IARSNQL----ERNIVSHSPS-----KMSW------------------GFPESSS 264

  Fly   525 CELKVK-----------SRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFG----TRYGS 574
            .|.:..           ||||:       .|.:|..|..   |:...|  ||:..|    :.:..
  Rat   265 SEEEENLDAYDWFAGNISRSQS-------EQLLRQKGKE---GAFMVR--NSSQMGMYTVSLFSK 317

  Fly   575 CVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCA 639
            .|.:.:....|                       ...|::.|||  :|.|...|
  Rat   318 AVNDKKGTVKH-----------------------YHVHTNAENK--LYLAENYC----------- 346

  Fly   640 PLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPL 704
             .|..||:....:.                               |.||          :||
  Rat   347 -FDSIPKLIHYHQH-------------------------------NSAG----------MIT--- 366

  Fly   705 LFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPRE 769
                               ||.....|.::|  :|.|       :.|.||.        ||..||
  Rat   367 -------------------RLRHPVSTKANK--VPVS-------VALGSGI--------WELKRE 395

  Fly   770 KLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNV 834
            ::.|...||.|:||.|      ::....|..:|||||:|:|:.|.:  ....|.|.:.::|||.:
  Rat   396 EIALLKELGSGQFGVV------QLGKWKGQYSVAVKMIKEGAMSED--EFFQEAQTMMKLSHPKL 452

  Fly   835 IKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGM 899
            :|..|.|:......::.||...|.|.:||:          :...|:|.   ..:|...:.:|:||
  Rat   453 VKFYGVCSKKYPIYIVTEYITNGCLLNYLK----------NHGKGLES---SQLLEMCYDVCEGM 504

  Fly   900 AYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHV 964
            |:|...:.:||||||||.|:......|:||||:||.|. ||.|:.....:.||||.|||......
  Rat   505 AFLESHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVL-DDQYVSSVGTKFPVKWSAPEVFHYFK 568

  Fly   965 YTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEP 1029
            |:||||||:||:|.||:.:||..||.......:...:..|:|:.||:..|:.:|.|:.:||.:.|
  Rat   569 YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELP 633

  Fly  1030 NGRPSFKFLASEFEKL 1045
            ..||:|:.|.|..|.|
  Rat   634 EKRPTFQQLLSAIEPL 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	98/276 (36%)
Bmx	NP_001102486.1	PH_Btk	25..151	CDD:269944	33/186 (18%)
		SH2_Tec_Bmx	269..374	CDD:198262	31/216 (14%)
		Protein Kinases, catalytic domain	392..647	CDD:473864	98/276 (36%)