Protein Alignment Ret and Ptk6

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001102438.1
• Gene: Ptk6 / 366275
• RGDID: 1309098
• Length: 451
• Species: Rattus norvegicus
• Alignment Length: 284
• Identity: 104/284 - (36%)
• Similarity: 154/284 - (54%)
• Gaps: 24/284 - (8%)

  Fly   764 WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQE 828
            ||.|||:..|...||.|.||:|.:|.      ..|:..||||::.: .|.:......:|.|.:::
  Rat   184 WERPREEFTLCKKLGSGYFGEVFEGL------WKGLVRVAVKVISR-DNLLHQHTFQAEIQAMKK 241

  Fly   829 VSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAW 893
            :.|.:::.|....|:.:...:|.|....|||...||.|.:.:...::..|            ||.
  Rat   242 LRHKHILSLYAVATAGDPVYIITELMPKGSLLQLLRDSDEKDLPILELVD------------FAS 294

  Fly   894 QICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPE 958
            |:.:||.||.....:||||||||||:.:..:||:.||||.| :.::|.||.|..: ||.||.|||
  Rat   295 QVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLAR-LVKEDIYLSRDHN-VPYKWTAPE 357

  Fly   959 SLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRT 1023
            :|:...|:.||||||||||..|:.:.|..||||::....:..:..||||..|..|...::.::.:
  Rat   358 ALSRGHYSIKSDVWSFGVLLHEIFSRGQMPYPGMSNHETFLRVDAGYRMPCPLECPPNIHKLMLS 422

  Fly  1024 CWADEPNGRPSFKFLASEFEKLLG 1047
            ||:.:|..||.||.|.   |||.|
  Rat   423 CWSRDPKQRPCFKDLC---EKLSG 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	99/278 (36%)
Ptk6	NP_001102438.1	SH3_Brk	12..69	CDD:212781
		SH2_PTK6_Brk	75..174	CDD:198221
		Protein Kinases, catalytic domain	184..444	CDD:473864	104/284 (37%)