DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Nrk

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	187/781 - (23%)
Similarity:	297/781 - (38%)	Gaps:	191/781 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 IVSRV--------DAMSATANVCYHINLSKLHESEQELPQALPLRARQH-RIFESE-EFNGDSA- 414
            :|.||        .|..|...:|..:..|..|.:.....:. |:..|.| |..|.| |.||..|
  Fly     9 VVERVLRGMVLKWGANLAVLGLCVFLFASATHANSLNAIEE-PVTRRHHQRHHEREREENGYCAP 72

  Fly   415 --GR------------SLSPPTVDYDKD---VSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVE 462
              |:            ||..||..:..:   .:::....|:              |..:..:..|
  Fly    73 YSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISD--------------LTGLCREAAE 123

  Fly   463 DKLGAFGITS--TSGIVFVKNPQVLEEAPET-IYFLNVTWIDQQRLSHVRVINVHLVHGRPENTS 524
            ..|.|:...:  ..|...||.|...|:...| :.|....|:              |:..:.|.
  Fly   124 KMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWV--------------LIEEKKER-- 172

  Fly   525 CELKVKSRSQ----TCAQIKYQSQCVR-----YCGLATGGGS-----CQWRGSNSAMFGTR--YG 573
             .:.:|||..    .|:.:.:.:..:|     |.||.....|     |: .|:.....||.  ..
  Fly   173 -NMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCR-NGNGRFYMGTMNVSK 235

  Fly   574 SCVP----ESRYCPDHVCDPLEELNPMACPQDCTPAGRIVG--PH----SSNENKRGIYSASGTC 628
            |.:|    :::|...|...||.....:.....|..||   |  ||    :.:|:.|  :......
  Fly   236 SGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAG---GEEPHPWCYTVDESVR--WQHCDIP 295

  Fly   629 ICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDR 693
            :|.|....:...|:...||:|                         ...|.::.:|...||..
  Fly   296 MCPDYVDPNAVDLNTPIKMEK-------------------------FFTPSMIFLLAGIGFVA-- 333

  Fly   694 SCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFE 758
                 ::|   |.:::||...:::.|...:..|    ..:::.::...||||.. ..|.:.....
  Fly   334 -----IVT---LHLMILLVYKLSKHKDYSQPAG----AATAECSVSMRGGGDCG-GNLNTSRETL 385

  Fly   759 SGD------AKW-------------------------------------EFPREKLQLDTVLGEG 780
            .|:      |||                                     |:||..:.....||:|
  Fly   386 GGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQG 450

  Fly   781 EFGQVLKGFATEIAGLPGIT------TVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLG 839
            .||:|.:      |..||:.      .|||||||..::....|....|..||.|..|||:::|||
  Fly   451 AFGRVFQ------ARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLG 509

  Fly   840 ACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSE 904
            .|.......|:.||...|.|..:||.............|.:: :|...:|..|..|..||.||||
  Fly   510 VCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQ-LNELHLLQMAANIAAGMLYLSE 573

  Fly   905 LKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKS 969
            .|.||||||.||.|:.:....||:||||:..:|..|.|.....|.:|::||..||:..:.::.:|
  Fly   574 RKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLES 638

  Fly   970 DVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPS 1034
            |||::|:..||:.:....||.|:..:.:...:|.|..:..|:|...:||:::|.||..:|:.||.
  Fly   639 DVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPG 703

  Fly  1035 F 1035
            |
  Fly   704 F 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	94/272 (35%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	94/271 (35%)
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	31/175 (18%)
		KR	217..299	CDD:214527	19/87 (22%)
		PTKc_Musk	435..713	CDD:133181	97/277 (35%)
		Pkinase_Tyr	441..707	CDD:285015	94/271 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455302
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940