Protein Alignment Ret and Drl-2

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_610835.2
• Gene: Drl-2 / 36436
• FlyBaseID: FBgn0033791
• Length: 648
• Species: Drosophila melanogaster
• Alignment Length: 284
• Identity: 86/284 - (30%)
• Similarity: 141/284 - (49%)
• Gaps: 17/284 - (5%)

  Fly   771 LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVI 835
            |..:.::.||.||::..|...|..      ...||.:..|::..:...||.:..||..|||.:::
  Fly   381 LSYEELVKEGTFGRIYAGKLGESC------EALVKTVIDGASLTQVACLLQDASLLIGVSHQHIL 439

  Fly   836 KLLGACTSSEA-PLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGM 899
            ..|.|.|.... |.:...:...|:|:.||:.||:...|          ::.:.::.|...|.||:
  Fly   440 APLLANTELPGPPEIAYPHPSKGNLKMYLQKSRESSTA----------LSTRQLVEFGLHITKGL 494

  Fly   900 AYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHV 964
            |||..|.:||:|:|.||..|.:....||.|..|:||::.||.......:..|:||::.|||...|
  Fly   495 AYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLGDNENRPLKWLSLESLQKRV 559

  Fly   965 YTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEP 1029
            |.::.|||:.||..|||:||...|:..:....|.:.|..|:|:::|.||.:..::::..||..|.
  Fly   560 YATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEA 624

  Fly  1030 NGRPSFKFLASEFEKLLGNNAKYI 1053
            ..||:...|.|..:....:...||
  Fly   625 KQRPTPSQLLSYLQDFHADLGMYI 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	84/278 (30%)
Drl-2	NP_610835.2	WIF	30..156	CDD:460414
		PTK_Ryk	373..644	CDD:270639	84/278 (30%)