Protein Alignment Ret and Y50D4B.6

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_503375.2
• Gene: Y50D4B.6 / 3565593
• WormBaseID: WBGene00021745
• Length: 421
• Species: Caenorhabditis elegans
• Alignment Length: 460
• Identity: 125/460 - (27%)
• Similarity: 202/460 - (43%)
• Gaps: 89/460 - (19%)

  Fly   692 DRSCM--FF---VITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALM-- 749
            ||:.:  |:   ||...:||..:.....:.:.:..:.|..:..:..||.|..|.|...:.:|:
 Worm     3 DRNILVIFYCIVVIALSVLFYYVWKFYYLRKEEHEETRSLESGIIHSSSQKTPSSVRENESLLQA 67

  Fly   750 ------------PLQSGFRFESGDAKWEFPREKLQLDTV--LGEGEFGQVLK---------GFAT 791
                        |:.:..:....|.::|....|.....:  ||.|.:|:|.|         |..:
 Worm    68 NEENVPIGLETEPINAIIKNLKFDERFEIDVNKFSFYNLSFLGNGYYGKVFKERMHKKQKNGLDS 132

  Fly   792 EIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYAR 855
            |     ....||||...:..:..|...:..|..::..| .|||::.|:....::|. |::.|:..
 Worm   133 E-----NSLEVAVKRALRPEDPSEQQLMCEELNVMCVVGKHPNILALIRWIRTNEI-LIVSEFVE 191

  Fly   856 YGSLRSYLRLSRK-----IECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAAR 915
            .|.|..|||..|:     |.|.    .|....:....:|:||:||..||.:|..:..||||||.|
 Worm   192 KGDLVEYLRARRRYFNKDIVCV----EDNGRLLCPTDLLSFAFQIANGMKFLGNVACVHRDLALR 252

  Fly   916 NVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESL-----ADHV-YTSKSDVWSF 974
            ||.:...:|.:|:||||.|.....:.|.|::....|:||:|||..     .::: :.||||:||:
 Worm   253 NVFVKRNRIIRIADFGLARWHENKEYYRKKTDVGFPMKWLAPECFEFEQERENIKFDSKSDIWSY 317

  Fly   975 GVLCWELITLGASPYPGI--AP---QNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPS 1034
            ||..:|:.:||.|||.|:  .|   |.|...::.|.::..||:.|:.:|..:::||...|:.||.
 Worm   318 GVCLYEIFSLGVSPYEGLDFRPDYFQGLMKYVRDGNQLPSPEHGSDKIYEFMQSCWNLNPDKRPV 382

  Fly  1035 FKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGEPESLQHLWSPPKIAYDIHDQ 1099
            |......|:|||           ..||.|.:     ..:..|:...|.||
 Worm   383 FSECRDFFQKLL-----------QQVSKPFF-----ENLLKEIQNEEKLQ--------------- 416

  Fly  1100 ATSYD 1104
             ||||
 Worm   417 -TSYD 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	97/306 (32%)
Y50D4B.6	NP_503375.2	PTKc	109..391	CDD:270623	92/291 (32%)