DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and fgfr2

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:XP_068081038.1 Gene:fgfr2 / 352940 ZFINID:ZDB-GENE-030323-1 Length:840 Species:Danio rerio


Alignment Length:929 Identity:250/929 - (26%)
Similarity:376/929 - (40%) Gaps:270/929 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 GRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVS------RVDAMSATA--------NVCYH 377
            |||.....|....:.:|:|.......:|....|..||      ::|.::.:|        ..|..
Zfish     7 GRPRRRGGCGDTPTTDGMFARGWLLGALLLMTLATVSVARPSLKIDLVNTSAPEEPPTKNQNCVP 71

  Fly   378 INLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDY-------DKDVSVYRSA 435
            : |..:|..|. |....||......::..:..:.....|:|  .|.|:       .||..:|..:
Zfish    72 V-LFSVHPGEL-LKLKCPLSGADDVVWTKDSSSLRPDNRTL--VTRDWLQISDATPKDSGLYSCS 132

  Fly   436 ASNFRVVQPDSFL--------------------------DLMRLRSIRF-DIVEDKLGAFGITST 473
            |:..|.....||:                          :.|||....| :.:|.||.|....:|
Zfish   133 ATGSRDCDVFSFIVNVTDAISSGDDEDDTERSDDVGADGEQMRLPYWTFPEKMEKKLHAVPAANT 197

  Fly   474 SGIVFVK-------NPQVLEEAPETIYFLNVTWIDQQ--------RLSHVRVINVHLVHGRPENT 523
                 ||       ||:     |:..:..|.....|:        ||.|..:|...:|.....|.
Zfish   198 -----VKFRCAAAGNPK-----PKMRWLKNAKPFRQEDRMGGYKVRLQHWTLIMESVVPSDKGNY 252

  Fly   524 SC-------------ELKVKSRS------------QTCAQIKYQSQCVRYCGL-ATGGGSCQWRG 562
            :|             .|.|..||            ....|:...::.|  |.: :......||  
Zfish   253 TCLVENQYGSINHTYTLDVVERSPHRPILQAGLPANVTVQVGQDAKFV--CKVYSDAQPHIQW-- 313

  Fly   563 SNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIV---GPHSSNENKRGIYSA 624
               ....|:.|     |||.||.:                 |..|::   |.:::::....:|..
Zfish   314 ---LQHYTKNG-----SRYGPDGL-----------------PYVRVLKTAGVNTTDKEIEVLYLP 353

  Fly   625 SGTCICEDNGKCSC------------APLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQD 677
            :.|  .||.|:.:|            |.|...|....|              :....||:.....
Zfish   354 NVT--FEDAGEYTCLAGNSIGISYHTAWLTVHPAETNP--------------IETDYPPDYVEIA 402

  Fly   678 PMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKM-----------------LQRRL 725
            ...:||              |:|.|  :.|::::|.:....|.                 |:|::
Zfish   403 IYCIGV--------------FLIAC--MVVIVVVCRMRTSAKKPDFSSQPAVHKLTKQIPLRRQV 451

  Fly   726 GKQSMTTSSKQA-----------------------LPESGGGDFALMPLQSGFRFESGDAKWEFP 767
            ...|.::||..:                       |||                    |.:|||.
Zfish   452 TVSSDSSSSMSSSTPLVRITTRRSSAHDDPIPEYDLPE--------------------DPRWEFS 496

  Fly   768 REKLQLDTVLGEGEFGQVLKGFATEIAGL-----PGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            |:||.|...||||.||||:   ..|..|:     ....||||||||..:...:...|:||.::::
Zfish   497 RDKLTLGKPLGEGCFGQVV---MAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 558

  Fly   828 EVS-HPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGV-----EPVNVK 886
            .:. |.|:|.||||||......:|:|||..|:||.|||..|.   .|::::..:     ||:..|
Zfish   559 MIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP---PGMEYSYDIARVSDEPLTFK 620

  Fly   887 MVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVP 951
            .:::..:|:.:||.||:..|.:||||||||||:.:..:.||:||||.|||:..|.|.|.:..|:|
Zfish   621 DLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTTNGRLP 685

  Fly   952 VKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEA 1016
            |||||||:|.|.|||.:|||||||||.||:.|||.||||||..:.|:.|||.|:|||:|.||:..
Zfish   686 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNE 750

  Fly  1017 VYSIVRTCWADEPNGRPSFKFLASEFEKL--LGNNAKYIDL----ETNAVSNP-----LYCGDDS 1070
            :|.:::.||....:.||:||.|..:.:::  |..|.:|:||    |..:.|.|     ...||||
Zfish   751 LYMMMKDCWHAISSHRPTFKQLVEDLDRILTLATNEEYLDLCAPVEQYSPSFPDTRSSCSSGDDS 815

  Fly  1071 ALITTELGEPESL---QHL 1086
            ......|.:...|   ||:
Zfish   816 VFSHDPLADEPCLPKYQHI 834

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 130/291 (45%)
fgfr2XP_068081038.1 Ig 56..148 CDD:472250 19/95 (20%)
Ig strand B 82..86 CDD:409353 1/3 (33%)
Ig strand E 114..118 CDD:409353 1/3 (33%)
Ig strand F 128..133 CDD:409353 1/4 (25%)
Ig strand G 141..144 CDD:409353 0/2 (0%)
IgI_2_FGFR 177..271 CDD:409443 21/103 (20%)
Ig strand A 177..180 CDD:409443 0/2 (0%)
Ig strand A' 188..193 CDD:409443 3/4 (75%)
Ig strand B 197..205 CDD:409443 3/12 (25%)
Ig strand C 211..216 CDD:409443 0/4 (0%)
Ig strand C' 219..221 CDD:409443 0/1 (0%)
Ig strand D 230..233 CDD:409443 0/2 (0%)
Ig strand E 237..242 CDD:409443 1/4 (25%)
Ig strand F 251..258 CDD:409443 2/6 (33%)
Ig strand G 261..271 CDD:409443 1/9 (11%)
IgI_3_FGFR2 279..383 CDD:409444 23/134 (17%)
Ig strand A 279..282 CDD:409444 0/2 (0%)
Ig strand A' 286..290 CDD:409444 0/3 (0%)
Ig strand B 298..305 CDD:409444 2/8 (25%)
Ig strand C 309..316 CDD:409444 2/11 (18%)
Ig strand D 331..336 CDD:409444 1/4 (25%)
Ig strand E 348..353 CDD:409444 1/4 (25%)
Ig strand F 361..369 CDD:409444 2/7 (29%)
Ig strand G 372..380 CDD:409444 1/7 (14%)
PTKc_FGFR2 475..787 CDD:270679 139/337 (41%)

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