DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Ror

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	363	Identity:	111/363 - (30%)
Similarity:	185/363 - (50%)	Gaps:	41/363 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 LLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAK----- 763
            |:|:::...:|..:|.::  ..|.:::...:..:..::..|:..|...|...|...|:..
  Fly   327 LIFIIIFAIILFKRRTIM--HYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVAL 389

  Fly   764 -------------WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGIT--TVAVKMLKKGSNS 813
                         ..|..:.::....||||.||:|.||...:    |..|  |||:|.||:.::.
  Fly   390 NSKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQLLQ----PNKTTITVAIKALKENASV 450

  Fly   814 VEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIE---CAGVD 875
            ........|.:|:.::.|.|::.:||...:.|...::.||...|.|..:|..:...|   .:.::
  Fly   451 KTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLE 515

  Fly   876 FADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDD 940
            |            |..|.||.:||.|||....|||||||||.|:.:|.:.|||||||:||:|..|
  Fly   516 F------------LQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSD 568

  Fly   941 AYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGY 1005
            .|..:|:..:||:||..||:....:|::||||||||:.||:.:.|..||.|.:.|.:.:|:::..
  Fly   569 YYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQ 633

  Fly  1006 RMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            .:..||||..||||::..||.::...||:|..:::..:
  Fly   634 LLSAPENCPTAVYSLMIECWHEQSVKRPTFTDISNRLK 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	100/279 (36%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	100/275 (36%)
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568
		KR	235..312	CDD:214527
		PTKc_Ror	404..673	CDD:270642	101/284 (36%)
		Pkinase_Tyr	410..670	CDD:285015	100/275 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455303
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940