Protein Alignment Ret and Btk

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 279
• Identity: 95/279 - (34%)
• Similarity: 152/279 - (54%)
• Gaps: 20/279 - (7%)

  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            |||....:|.|...||.|:||.|.:|      ...|....||||:|:|:.|.:  ..:.|.:::.
  Fly   518 KWEIHPMELMLMEELGSGQFGVVRRG------KWRGSIDTAVKMMKEGTMSED--DFIEEAKVMT 574

  Fly   828 EVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892
            ::.|||:::|.|.|:......::.||.::|||.:|||...|....           |:.::|...
  Fly   575 KLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIG-----------NMGLLLDMC 628

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .|:.|||.||.....:||||||||.|:....:.|::||||.|.|. ||.|......:.|:||..|
  Fly   629 IQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL-DDQYTSSGGTKFPIKWAPP 692

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            |.|....::||||||::|||.||:.|.|..||..:....:...::.|..:::|::|::.:|.:::
  Fly   693 EVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMK 757

  Fly  1023 TCWADEPNGRPSFKFLASE 1041
            .||:..|..||:|:.|..:
  Fly   758 LCWSHGPEERPAFRVLMDQ 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	92/272 (34%)
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637	92/276 (33%)