Protein Alignment Ret and Pvr

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001162911.1
• Gene: Pvr / 34127
• FlyBaseID: FBgn0032006
• Length: 1577
• Species: Drosophila melanogaster
• Alignment Length: 678
• Identity: 180/678 - (26%)
• Similarity: 268/678 - (39%)
• Gaps: 246/678 - (36%)

  Fly   704 LLFVLLL-LCLLIAQR--KMLQRRLGKQSMTTSSKQALPESGGGDF------------------A 747
            :||::|: ||:.:|.|  |..:|.|           ||..:|..:|                  .
  Fly   867 ILFLILIGLCVFLAVRYQKEHKRHL-----------ALKAAGLANFEEGAVGHINPDLTLDEQAE 920

  Fly   748 LMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSN 812
            |:|....|         |||||.|:|...||.|.||.||||.|..|......|||||||:|..::
  Fly   921 LLPYNREF---------EFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATAD 976

  Fly   813 SVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAP---LLIIEYARYGSLRSYLRLSRK----- 868
            :....||:||.:::..: .|.||:.||||.|.:.|.   ::|:||.|:|:::::|..:||
  Fly   977 NEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQ 1041

  Fly   869 -------------------------------IECAGVDF-------------------------- 876
                                           ::.|.|.|
  Fly  1042 INPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDND 1106

  Fly   877 ------------------------------------------------------ADGVEPVNVKM 887
                                                                  .|..|.:.|..
  Fly  1107 PRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTT 1171

  Fly   888 V--LTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRV 950
            |  :::|:|:.:||.|||..|::|.||||||:||.:..:.||.||||.|.:|..|.|.|....::
  Fly  1172 VDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKL 1236

  Fly   951 PVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAP-QNLWSLLKTGYRMDRPENCS 1014
            |:||:|.|||:|||:::.|||||:|::.||:.:|...|||||.| |.|::.|..||||::|:..:
  Fly  1237 PIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFAN 1301

  Fly  1015 EAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNN--AKYIDLETNAV-SNPLYCGDDSALITTE 1076
            :.:|.|:..||...|..||.|..|...|..:||.:  :.|:||....: ||..|....|......
  Fly  1302 QELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLAL 1366

  Fly  1077 LGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYEND 1141
            :|.|:.|                              :.|.|.|          .||.::.
  Fly  1367 MGSPDEL------------------------------APAAPRY----------VNGHIVP---- 1387

  Fly  1142 LRFPLNIRKSSCTPSYSNMT--SEPPATTSLPHYSVPVKRGRSYLDMTNKSLIPDNLDSREFEKH 1204
                 :||.......|..|:  |:|.|.|::  :|.....|.|       |..||
  Fly  1388 -----DIRIEELPDDYMEMSRDSDPDACTAI--FSPTRLEGES-------SDFPD---------- 1428

  Fly  1205 LSKTISFRF---------SSLLNLSETK 1223
            .|...:|.|         |:.||...:|
  Fly  1429 FSSETTFNFPGARQSPTLSNNLNSGSSK 1456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	122/401 (30%)
Pvr	NP_001162911.1	IG_like	346..432	CDD:214653
		Ig strand C	363..366	CDD:409353
		Ig strand E	396..400	CDD:409353
		Ig strand F	410..415	CDD:409353
		Ig strand G	425..428	CDD:409353
		Ig	458..533	CDD:472250
		Ig strand B	459..463	CDD:409353
		Ig strand C	472..476	CDD:409353
		Ig strand E	497..503	CDD:409353
		Ig strand F	513..518	CDD:409353
		Ig	671..>742	CDD:472250
		Ig strand B	674..678	CDD:409353
		Ig strand C	687..691	CDD:409353
		Ig strand E	717..721	CDD:409353
		Ig strand F	731..736	CDD:409353
		Ig	779..851	CDD:472250
		Ig strand B	781..785	CDD:409570
		Ig strand C	794..798	CDD:409570
		Ig strand E	816..821	CDD:409570
		Ig strand F	831..836	CDD:409570
		Ig strand G	844..847	CDD:409570
		Protein Kinases, catalytic domain	927..1332	CDD:473864	126/413 (31%)