Protein Alignment Ret and Ddr

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Alignment Length: 1179
• Identity: 249/1179 - (21%)
• Similarity: 402/1179 - (34%)
• Gaps: 351/1179 - (29%)

  Fly     3 STTIVFVTLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQF-QVLRMEDNRLA 66
            |.|:.::||..|:...:......|..|.|      |....|..:.:::|:... |.|.||...:|
  Fly    60 SKTLCWLTLTLILLANRFGMGTAVGTPET------PAAVGSNGLLAEMPIGTCKQALGMESGAIA 118

  Fly    67 SDYLYSLE----------QNPLLRINSSSG-----EIYMR--TDYRSPNSSATFLVTA------F 108
             |:..:..          |:..|:|:::.|     .:..|  |:|...:.....||:|      |
  Fly   119 -DFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRF 182

  Fly   109 PRDQPDHELLNVSHLSLEVTPQPLEEYCSE-LEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGA 172
            .:.|           ..|.|...:.||... |:....|.|.|               .:.||.|.
  Fly   183 GKGQ-----------GQEYTEAYVIEYWRPGLKKWIRWRSLQ---------------GKEVLPGN 221

  Fly   173 LN--SRAAKYLCPHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHD-----ELNGLNAKAGQLQARI 230
            :|  |.....|.|.|            |..|. |||.....|..     |:.|...:.|.:...|
  Fly   222 INTYSEVENVLQPSV------------FASKV-RLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSI 273

  Fly   231 TCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVD--- 292
                      .:...|.:||.|.|:..:|  .:|.    |.|:.......|.:.||.....|
  Fly   274 ----------PKGMQRGMDIDLSDKTYDG--YEEG----DHYVNGLGQLVDGQRGKDNFRADING 322

  Fly   293 -----------KDTLEAN-AHLVY---------AVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQ 336
                       .|||... ..:::         ||...::.:|..|...:           |..:
  Fly   323 LGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVF-----------VHAK 376

  Fly   337 LRFSRNG--------VFRETPYCVSLEARDLTI----------------------VSRVDAMSAT 371
            :.||..|        .|...|..|...|||:||                      :|.:..:||.
  Fly   377 VFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFISAP 441

  Fly   372 ANVCYHINLSKLHESEQELPQALPL-RARQHRIFESEEFNGDSAGRSLSPPTVDYDKD----VSV 431
              |..:......:..:|.:....|| |....|...|.........:.:||..:|:.:.    |.|
  Fly   442 --VVGNFTDELANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVISPKPIDHQEPETSFVGV 504

  Fly   432 YRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAF------GITSTSGIVFVKNPQVLEEAPE 490
            ..:..... ::...:|:.|:..|:......|:.|.||      ...:.:|::.|
  Fly   505 IITVLGTI-IMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKV----------- 557

  Fly   491 TIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGG 555
                  ||.:|....|    |:.:.::..|.|.:   ...|.:..|.....|.|.|.
  Fly   558 ------VTTMDDNESS----IDKNSLYHEPFNAN---MYTSAASACPMNDLQRQHVS-------- 601

  Fly   556 GSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDP-----LEELNPMA--CPQDCTPAGRIVGPHS 613
                                 |:....||.||..     :::|.|.|  |...| ..|...||..
  Fly   602 ---------------------PDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGC-GTGTGTGPGR 644

  Fly   614 SNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDP 678
            .:..:..:.:...|....::...:..||...|                       .||  ||:
  Fly   645 GSSPEFVVATGKVTASARNSLNAATLPLPSPP-----------------------VPP--PLE-- 682

  Fly   679 MLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQ---SMTTSSKQA-LP 739
                             .::..| |           ::.:.|.....|.|   |:::|:..| .|
  Fly   683 -----------------KYYAAT-P-----------VSSKPMPVAPPGSQSSGSLSSSTTAATTP 718

  Fly   740 ESG--------------GGDFALMPLQSGFRFESGDAK-WEFPREKLQLDTVLGEGEFGQVLKGF 789
            .||              ..:||      ....|..:.: .||||:.|.:...||.|.||: |...
  Fly   719 TSGVVGVGKPHHYNLDMSANFA------DINEERANCQVQEFPRQSLVIVEKLGSGVFGE-LHLC 776

  Fly   790 ATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYA 854
            .|.:.   ..|.|||..|:.|:|........|:.:.|.::|.|||.:|:|||...|...::.:|:
  Fly   777 ETNVL---NATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYS 838

  Fly   855 R-YGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTF------AWQICKGMAYLSELKLVHRDL 912
            . .|.|..:|: ....|.:|         :..|..|:|      |.||..||.:|.::..|||||
  Fly   839 HCLGDLNQFLQ-EHVAETSG---------LMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDL 893

  Fly   913 AARNVLLADGKICKISDFG--LTRDVYEDD-----AYLKRSRDRVPVKWMAPESLADHVYTSKSD 970
            |.|:.::......|:...|  :.|..|..|     .:..|....:|::|||.||:....:|:|||
  Fly   894 ATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSD 958

  Fly   971 VWSFGVLCWELITLG-ASPYPGIAPQNL---WSLLKTGYRMDR----PENCSEAVYSIVRTCWAD 1027
            ||||.|..||::|.. ..||..::.:::   ..|:...|:|..    |.||...:|.::..||..
  Fly   959 VWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQR 1023

  Fly  1028 EPNGRPSFK 1036
            :.:.||||:
  Fly  1024 DESSRPSFR 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	87/289 (30%)
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014	40/191 (21%)
		PTKc_DDR	753..1040	CDD:270644	91/294 (31%)