Protein Alignment Ret and tor

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_061502652.1
• Gene: tor / 3290041
• VectorBaseID: AGAMI1_007799
• Length: 1147
• Species: Anopheles gambiae
• Alignment Length: 1077
• Identity: 232/1077 - (21%)
• Similarity: 367/1077 - (34%)
• Gaps: 405/1077 - (37%)

  Fly   329 PHTIVSCQLRFSRNGVFRETPYCVSLEA----------RDLTIVSRVDAMSATANVCYHINLSKL 383
            |...::...|.|.|.:....|  .:|||          :|..:..::.|.....|     .|:.|
Mosquito   102 PSLRINLICRDSTNLIIEIKP--TALEAGGGVGGNHHHQDSKLTPKLSAPGGNQN-----QLNAL 159

  Fly   384 HE---SEQELPQALPLRARQ----------HRIFESEEFNGDSAGRSLSP-------PTVDYDKD 428
            .:   |.:.|..|.|.|:|:          .::.|.::.:..:....|.|       ||:....|
Mosquito   160 RDRSASAESLESAAPARSRRAIGADGPLSAGQLTERQKASSGTRTNLLQPTAGKIDGPTLHGSVD 224

  Fly   429 VSVYR-SAASNFRV-VQPD---------SFLDLMR----LRSIRFDIVEDKLGAFGITSTSGIVF 478
            .|... ..|.|..| ||||         :..|..|    :..::....|.:||       ..||:
Mosquito   225 ASADEDDEADNVAVKVQPDREHYQRALAAEQDRTRPPVPIYLVKVQDSEQELG-------DRIVY 282

  Fly   479 VKNPQVLE---EAPETIYFLNVTWIDQQRLSHVRVINVH----LVHGRPENTSCELKVKSRSQTC 536
            :.|..:::   .||...|.:..|.:..:  .....:..|    |.|........::.|: |.:|.
Mosquito   283 MSNASLVKIENLAPNRRYNVTATMLTSE--YEYYYVEKHQYRTLPHDYMPGIVTDIMVE-RFETN 344

  Fly   537 AQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQD 601
            |:   .|:.|        .....|   ..|...|.:...|..:.|.||.:..|::...|....:.
Mosquito   345 AR---DSRLV--------DAVISW---TPAKDRTCHYEIVCHASYSPDFLLKPIDVQQPEVLYKY 395

  Fly   602 CTPAGRIVGPHSSNENKRGIYSA------------SGTCICEDNGKCSCAPLDEEPKMKKPRKRK 654
            ...|.::...:......:...:|            :.:|....||...|||
Mosquito   396 TIKALKLSANYMIAVRSKNTQNAMRESQLHWQSFHTPSCTNHTNGTQVCAP-------------- 446

  Fly   655 NETEAEPLLGVRRGTPP------------------------------NQPLQDP----------M 679
                 ||:..||....|                              |...::|          .
Mosquito   447 -----EPITNVRVTQVPLYGDHYQLNISWDRPTIAPDSYVVKVFDLHNPETEEPGNSVTKNLTGD 506

  Fly   680 LLGVLNVAGFEC------------------------------------DRSCMFFVITCPLLFVL 708
            .:||| :..||.                                    .|:.:.|:|..|:|.:.
Mosquito   507 AVGVL-IESFEMFGPHFEVLVAAYSRVGVSSENTIKALQIGRVSSESWIRTKLVFIILTPVLMIG 570

  Fly   709 LL---LCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFA--------LMPLQSGFRFESGDA 762
            ||   :.|:..:|..|:|...:.......:|..|.....:|.        |:.....|   |.|.
Mosquito   571 LLKISISLICRRRAKLKRYEERCEYFKELEQKAPVDPSTEFEPTSKQMQDLLATSHPF---SPDL 632

  Fly   763 ------KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPG--ITTVAVKMLKKGSNSVEYMAL 819
                  :.|...|.::|..:||||.||.|.|| ..:.:|..|  ...|||||||:.....:.:..
Mosquito   633 IAPINDELEIEMEHIKLHDMLGEGAFGLVRKG-VLQRSGDDGEPAQPVAVKMLKECPRVEDILEF 696

  Fly   820 LSEFQLLQEV-SHPNVIKLLGACTSS-EAPLLIIEYARYGSLRSYLRL----------------- 865
            ..|.::::.| :||:::.::|.||.: ...:|:.||...|:|.:||||
Mosquito   697 RREMEVMKSVGTHPHIVGIVGHCTKNVRKMMLLTEYCGRGNLLNYLRLQWQRLLRQNRTTGTRSI 761

  Fly   866 -----------------------SRKIECA----------------------------------- 872
                                   :|.:|.|
Mosquito   762 GGTSGTNITATLPSPPPPPPPPPTRSLEMADHECLTPSLDNNKMPENVFNFDTSFVNDKKSLTYK 826

  Fly   873 ----------GVDF-----------------------------ADGVE----------------- 881
                      ||.|                             :||.|
Mosquito   827 NISDHRQTLLGVAFGLAGGSDGSSASRSPQIIENKLYPLFSDESDGDETAQLTHCTNACKNAVEI 891

  Fly   882 -------------------------PV-----------------------------NVKMVLTFA 892
                                     ||                             |...:|.|:
Mosquito   892 VEGTWEVGEDVKGSVRIKPCSCHGAPVDSTLTNNTVENRWYQSCSPQSEEEEDPLPNSGQLLEFS 956

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .||..||.:|:..|:|||||||||||:.|....||:||||:||:|:::.|.|.|..::|:||:|.
Mosquito   957 RQIALGMEFLARNKVVHRDLAARNVLVCDSNTVKIADFGLSRDIYQENLYRKTSNGKLPIKWLAL 1021

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            ||:...||||:|||||:|:|.:|:.|||.||||.|:...|...|::||||:||::|||.:|.::.
Mosquito  1022 ESMTHQVYTSQSDVWSYGILLYEICTLGGSPYPAISTNRLLRYLESGYRMERPKSCSELLYDLMY 1086

  Fly  1023 TCWADEPNGRPSFKFLASEFEKL----LGNNAKYIDL 1055
            :||...|..||:|..:....|:|    :.|:...|||
Mosquito  1087 SCWNLHPGERPTFSKIVHTVEQLQARDIANDPVVIDL 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	125/471 (27%)
tor	XP_061502652.1	None