Protein Alignment Ret and src

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_017209008.1
• Gene: src / 325084
• ZFINID: ZDB-GENE-030131-3809
• Length: 549
• Species: Danio rerio
• Alignment Length: 281
• Identity: 108/281 - (38%)
• Similarity: 159/281 - (56%)
• Gaps: 24/281 - (8%)

  Fly   764 WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQE 828
            ||.||:.|:||..||:|.||:|..|...      |.|.||:|.||.|:.|.|  |.|.|.|::::
Zfish   276 WEIPRDSLRLDVKLGQGCFGEVWMGTWN------GTTRVAIKTLKPGTMSPE--AFLQEAQVMKK 332

  Fly   829 VSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892
            :.|..:::|....  ||.|:.|: ||...|||..:|:            .|..:.:.:..::..|
Zfish   333 LRHEKLVQLYAVV--SEEPIYIVTEYMGQGSLLDFLK------------GDMGKMLRLPQLVDMA 383

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .||..||||:..:..|||||.|.|:|:.|..:||::||||.| :.||:.|..|...:.|:||.||
Zfish   384 SQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAP 447

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            |:.....:|.||||||||:|..||.|.|..||||:..:.:...::.||||..|..|.::::.::.
Zfish   448 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPAECPDSLHELML 512

  Fly  1023 TCWADEPNGRPSFKFLASEFE 1043
            |||..||..||:|::|....|
Zfish   513 TCWRKEPEERPTFEYLQGFLE 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	104/275 (38%)
src	XP_017209008.1	SH3	85..148	CDD:473055
		SH2_Src_Src	162..260	CDD:198228
		PTKc_Src	273..549	CDD:270656	108/281 (38%)