Protein Alignment Ret and Lck

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_006238994.1
• Gene: Lck / 313050
• RGDID: 2994
• Length: 520
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 153/540 - (28%)
• Similarity: 227/540 - (42%)
• Gaps: 177/540 - (32%)

  Fly   628 CICEDNGK---------C-SC----APLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDP 678
            |:|..|.:         | :|    .|||.  |...|.:..:|.. :||:......||..||||.
  Rat    14 CVCSSNPEDDWMENIDVCENCHYPIVPLDS--KSTLPIRTGSEVR-DPLVTYEGSLPPASPLQDN 75

  Fly   679 MLLGVLNV-------AGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGK----QSMTT 732
            :::.:.:.       .|||...                       |.::|::. |:    ||:||
  Rat    76 LVIALHSYEPSHDGDLGFEKGE-----------------------QLRILEQS-GEWWKAQSLTT 116

  Fly   733 SSKQALP--------------------------------------------ESGGGDFAL----- 748
            ..:..:|                                            ||..|.|:|
  Rat   117 GQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDF 181

  Fly   749 -------------MPLQSGFRFES---------------------------------------GD 761
                         ..|.:|..:.|                                       .:
  Rat   182 DQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWE 246

  Fly   762 AKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLL 826
            .:||.|||.|:|...||.|:||:|..|:..      |.|.||||.||:||.|.:  |.|:|..|:
  Rat   247 DEWEVPRETLKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQGSMSPD--AFLAEANLM 303

  Fly   827 QEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLT 890
            :::.||.:::|....|  :.|:.|| ||...|||..:|:....|:            :||..:|.
  Rat   304 KQLQHPRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTPSGIK------------LNVNKLLD 354

  Fly   891 FAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWM 955
            .|.||.:|||::.|...:||||.|.|:|::|...|||:||||.| :.||:.|..|...:.|:||.
  Rat   355 MAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLAR-LIEDNEYTAREGAKFPIKWT 418

  Fly   956 APESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSI 1020
            |||::....:|.||||||||:|..|::|.|..||||:....:...|:.||||.||:||.|.:|.:
  Rat   419 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLEKGYRMVRPDNCPEELYHL 483

  Fly  1021 VRTCWADEPNGRPSFKFLAS 1040
            :..||.:.|..||:|.:|.|
  Rat   484 MMLCWKERPEDRPTFDYLRS 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	110/272 (40%)
Lck	XP_006238994.1	SH3_Lck	76..129	CDD:212938	11/76 (14%)
		SH2_Src_Lck	134..234	CDD:198225	8/99 (8%)
		PTKc_Lck_Blk	248..511	CDD:270652	115/279 (41%)