DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and tek

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:XP_009299388.1 Gene:tek / 30747 ZFINID:ZDB-GENE-990415-56 Length:1117 Species:Danio rerio


Alignment Length:940 Identity:233/940 - (24%)
Similarity:365/940 - (38%) Gaps:242/940 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 HVSLEYSLNAGSS------H---FVLKQNRLYTRQTLDHDELNGLNAKAGQLQ-------ARITC 232
            :..:|.|:|..:|      |   .::..||. |...:|...||..:....::|       .|..|
Zfish   359 NTGVELSVNCSASGRPAPLHGDITLITANRT-TIAAVDTHTLNDQSTSVFRVQQVRVSSAGRWRC 422

  Fly   233 TVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYL--EQPYFQADEEAGKKVIYVDKDT 295
            .|. ::..|.:....:::|:..|..|.|.||.|..:....|  .:||......|...::|     
Zfish   423 QVN-NTHAQVEDEFTVEVKVPPRPQNPPVLQGSGPRHLLLLLNTEPYSGDGPIATTTLLY----- 481

  Fly   296 LEANAHLVYAVHNDSHG-LFRPDCHAYEADHTGRPHTIVSCQLRFSR---NGVFRETPYCV-SLE 355
            ..|:||...:.  .:|| |.|.| :.|       |.|....|::.||   .|..:..|... |.:
Zfish   482 RPASAHTWSSF--TAHGPLVRLD-NLY-------PMTQYLTQVQLSRPGPGGAGQAGPAATFSTQ 536

  Fly   356 ARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSP 420
            ..:|.:..::.|:|.||          |..|....|      |.||..:|               
Zfish   537 VLELPVGVKLSAVSQTA----------LLLSWDIAP------AEQHCTYE--------------- 570

  Fly   421 PTVDYDKDVSVYRSAA-SNFRVVQPDSFLDLMRLRSI----RFDIVEDKLGAFGITSTSGIVFVK 480
                    ||..::.| ...|..|..|....|.|..:    ::..........|....|...:..
Zfish   571 --------VSCLQAGAPGTLRTFQLPSNSSAMHLSDLKPRHKYQCTVRSSCGVGQNHPSASAWTL 627

  Fly   481 NPQVLEEAPETIYFLNV-------TWIDQQRLSHVR-VINVHLVHGRPENTSCELKVKSRSQTCA 537
            :...|...|..|...|:       ||...:..|..| ||....|.........||.|:::     
Zfish   628 SDPELPPPPANISIWNISDTSAVLTWAVAEGESVSRAVIRFQQVEQAQYRQQVELPVQTQ----- 687

  Fly   538 QIKYQSQCVRYCGLA--TGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQ 600
            |:..:.|.:   ||.  ||.....|..:|           :.||...|        .::.|..||
Zfish   688 QLHMRFQLL---GLRPNTGYQLQLWTVNN-----------MGESAESP--------PVSLMTLPQ 730

  Fly   601 DCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGV 665
                           :....:::|.|..                                     
Zfish   731 ---------------QESSALFAAHGHL------------------------------------- 743

  Fly   666 RRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLI-AQRKMLQRRLGKQS 729
                         :|..:|..||..|          |.   |||..|::: .:|..||||:    
Zfish   744 -------------LLYAILGSAGMTC----------CT---VLLAFCIVLQLKRNTLQRRI---- 778

  Fly   730 MTTSSKQALPESGGGDFALMP--------LQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVL 786
                 ...|.|.....|:..|        :.....|.:  .:|    ..:|...|||||.|||||
Zfish   779 -----HSILREEPAVHFSSAPPPHRRSAVVSRSLVFPA--LQW----SDIQFQDVLGEGNFGQVL 832

  Fly   787 KGFATEIAGLPGI-TTVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HPNVIKLLGACTSSEAPLL 849
            |....:    .|: ...|||.:|..::..::.....|.::|..:. |.|:|.|||||.......|
Zfish   833 KARIRK----DGLRMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHLLGACEHRGYLYL 893

  Fly   850 IIEYARYGSLRSYLRLSRKIECAGVDFADGV-----EPVNVKMVLTFAWQICKGMAYLSELKLVH 909
            .||:|.:|:|..:||.||.:|   .|.|..:     ..::.:.:|.|:..:.:||:|||:.:.:|
Zfish   894 AIEFAPHGNLLDFLRKSRVLE---TDPAFAIAHRTASTLSSQQLLAFSADVARGMSYLSQKQFIH 955

  Fly   910 RDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSF 974
            |||||||||:.:..:.||:||||:|.   .:.|:|::..|:||:|||.|||...|||:.|||||:
Zfish   956 RDLAARNVLVGENFVAKIADFGLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSY 1017

  Fly   975 GVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLA 1039
            |||.||:::||.:||.|:....|:..|..|:|:::|.||.:.||.:::.||.::|..||||..:.
Zfish  1018 GVLLWEVVSLGGTPYCGMTCAELYEKLPLGFRLEKPLNCDDEVYELMQQCWREKPFERPSFSQIL 1082

  Fly  1040 SEFEKLLGNNAKYIDLETNAVSNPLYCGDD 1069
            ....::|.....|::  |.......|.|.|
Zfish  1083 LSLGRMLEERKTYVN--TTLYEKFTYAGID 1110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 110/285 (39%)
tekXP_009299388.1 Ig_Tie2_1 25..121 CDD:463089
EGF_CA <231..255 CDD:238011
Ig 348..437 CDD:472250 16/79 (20%)
Ig strand B 364..368 CDD:409353 1/3 (33%)
Ig strand C 380..384 CDD:409353 0/3 (0%)
Ig strand E 405..409 CDD:409353 0/3 (0%)
Ig strand F 419..424 CDD:409353 2/4 (50%)
Ig strand G 432..435 CDD:409353 0/2 (0%)
fn3 541..621 CDD:394996 20/118 (17%)
FN3 633..717 CDD:214495 21/102 (21%)
PTKc_Tie2 809..1111 CDD:133219 117/320 (37%)
Blue background indicates that the domain is not in the aligned region.

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