Protein Alignment Ret and tie1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_001334673.5
• Gene: tie1 / 30746
• ZFINID: ZDB-GENE-990415-55
• Length: 1122
• Species: Danio rerio
• Alignment Length: 956
• Identity: 226/956 - (23%)
• Similarity: 390/956 - (40%)
• Gaps: 258/956 - (26%)

  Fly   232 CTVKLSSRDQRKFSRILDI--------KLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKV 288
            |.:..:.:::.|.:|....        :..:::|..|::.:.:|
Zfish   303 CLLSCNCKNKGKCNRFSGCQCSTGWRGQYCEKSDRAPEILDIAS--------------------- 346

  Fly   289 IYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRP---HTIVSCQLRFSRNGVFRETPY 350
                  .||.|.       |.||.:   .|.|     ||.|   |  :|.:||...:.|.:  .:
Zfish   347 ------NLEGNL-------NSSHKI---TCSA-----TGHPLPSH--LSIELRKLESTVLK--AF 386

  Fly   351 CVSLEARDLTIVSRVDAMSATANVCYHINLS----------KLHESEQELPQALP---LRARQHR 402
            ...|:::..|....:..:|...|..:...:|          .|...|...|.|.|   ||:.:..
Zfish   387 HTILDSKKSTAHFEIPRLSPEHNGLWECRVSTNGGQDSLKFTLTVKEPPYPTAAPKLLLRSSRQL 451

  Fly   403 IFES-EEFNGD-------------SAGRSLSP---------------PTVDYDKDVSVYRSAASN 438
            :.:: :.:.||             :...|.||               |:..|...|.:.|.....
Zfish   452 VVKAVDSYAGDGPIVSTKLLYKQVNTEDSWSPIIVHGSDQITLQNLKPSTKYHVRVQLARPGEGG 516

  Fly   439 FRVVQPDSFLDL-----------------MRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLE 486
            ...:.|::.::.                 .|..::|:.::    |.|  ...||.:........|
Zfish   517 EGPLGPEAIMETDCPEPTARPEIDSSSLEGRNVTLRWSLI----GRF--REASGFLVQLYGPYGE 575

  Fly   487 EAPETIYFLNVTWIDQQRLSH-------VRVINV---------HLVHGRPENTSCELKVKSRSQT 535
            :..|...||||..:....|.:       ||::|.         |.:|...:..|....|::.:.:
Zfish   576 KLWEETTFLNVLSVKLYNLEYHKNYQAVVRLVNCGSHGPPSRPHHIHIYKQGPSSPRNVQADALS 640

  Fly   536 CAQIKYQSQ--------CVRYCGLATGGGSCQWR--GSNSAMFGTRYGSCVPESRYCPDHVCDPL 590
            .:.::.:.|        .|:|        |.:::  |.:|
Zfish   641 ISAVRLRWQPPEDPNGGIVKY--------SIEYQPVGQSS------------------------- 672

  Fly   591 EELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKN 655
              |:|.            |...:.|:..:.:.|.:|:.:.:...:..         .|.|.:..:
Zfish   673 --LHPW------------VDTDNGNKTTKDVTSLNGSTLYQFRVRAF---------SKVPGEWSS 714

  Fly   656 ETEAE-PLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFV-----ITCPLLFVLLLLCLL 714
            ..:|: |..|:....|..|.:..|:..          |...:|.|     :|| :..:|.||.|.
Zfish   715 FVQAQTPGEGLSSFIPTTQQVGRPLAE----------DHQLLFAVVGSVAVTC-VTILLALLALF 768

  Fly   715 IAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGF-----RFESGDAKWEFP---REKL 771
            ..::.:|:||   ::.|.       :||.|:..::...||.     |.:.......:|   .|.:
Zfish   769 YIRKSVLKRR---RTFTY-------QSGSGEETILQFNSGTLTLTRRPKPSPEPLTYPILEWEDI 823

  Fly   772 QLDTVLGEGEFGQVLKGFATEIAGLPGI-TTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNV 834
            :.:.|:|||.||||:|....:    .|| .:.|:||||:.::..::.....|.::|.:: .|.|:
Zfish   824 KFEDVIGEGNFGQVIKAMVKK----DGIKMSAAIKMLKEFASENDHRDFAGELEVLCKLGQHTNI 884

  Fly   835 IKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVE-----PVNVKMVLTFAWQ 894
            |.|:|||.:.....:.||||.||:|..:||.||.:|   .|.|...|     .:..:.:|.||..
Zfish   885 INLIGACENRGYLYIAIEYAPYGNLLDFLRKSRVLE---TDPAFAKEHGTASTLTSQQLLQFAAD 946

  Fly   895 ICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPES 959
            :..||.|||:.:.:||||||||||:.|..:.||:||||:|.   ::.|:|::..|:||:|||.||
Zfish   947 VATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRG---EEVYVKKTMGRLPVRWMAIES 1008

  Fly   960 LADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTC 1024
            |...|||:||||||||||.||:::||.:||.|:....|:..|..||||::|.||.:.||.::|.|
Zfish  1009 LNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQC 1073

  Fly  1025 WADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDS 1070
            |.|.|..||.|..::.:..::......|:::.  ...|..|.|.|:
Zfish  1074 WRDRPYERPPFSQISVQLNRMQEARKAYVNMA--LFENFTYAGIDA 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	116/285 (41%)
tie1	XP_001334673.5	EGF_CA	<219..244	CDD:238011
		Ig	339..429	CDD:472250	23/135 (17%)
		Ig strand B	356..360	CDD:409556	1/6 (17%)
		Ig strand C	372..376	CDD:409556	1/3 (33%)
		Ig strand E	397..401	CDD:409556	0/3 (0%)
		Ig strand F	411..416	CDD:409556	0/4 (0%)
		Ig strand G	424..427	CDD:409556	0/2 (0%)
		FN3	<427..>774	CDD:442628	66/419 (16%)
		FN3	628..720	CDD:238020	17/147 (12%)
		Protein Kinases, catalytic domain	820..1116	CDD:473864	121/307 (39%)