DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and tie1

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:XP_001334673.5 Gene:tie1 / 30746 ZFINID:ZDB-GENE-990415-55 Length:1122 Species:Danio rerio


Alignment Length:956 Identity:226/956 - (23%)
Similarity:390/956 - (40%) Gaps:258/956 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   232 CTVKLSSRDQRKFSRILDI--------KLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKV 288
            |.:..:.:::.|.:|....        :..:::|..|::.:.:|                     
Zfish   303 CLLSCNCKNKGKCNRFSGCQCSTGWRGQYCEKSDRAPEILDIAS--------------------- 346

  Fly   289 IYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRP---HTIVSCQLRFSRNGVFRETPY 350
                  .||.|.       |.||.:   .|.|     ||.|   |  :|.:||...:.|.:  .:
Zfish   347 ------NLEGNL-------NSSHKI---TCSA-----TGHPLPSH--LSIELRKLESTVLK--AF 386

  Fly   351 CVSLEARDLTIVSRVDAMSATANVCYHINLS----------KLHESEQELPQALP---LRARQHR 402
            ...|:::..|....:..:|...|..:...:|          .|...|...|.|.|   ||:.:..
Zfish   387 HTILDSKKSTAHFEIPRLSPEHNGLWECRVSTNGGQDSLKFTLTVKEPPYPTAAPKLLLRSSRQL 451

  Fly   403 IFES-EEFNGD-------------SAGRSLSP---------------PTVDYDKDVSVYRSAASN 438
            :.:: :.:.||             :...|.||               |:..|...|.:.|.....
Zfish   452 VVKAVDSYAGDGPIVSTKLLYKQVNTEDSWSPIIVHGSDQITLQNLKPSTKYHVRVQLARPGEGG 516

  Fly   439 FRVVQPDSFLDL-----------------MRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLE 486
            ...:.|::.::.                 .|..::|:.::    |.|  ...||.:........|
Zfish   517 EGPLGPEAIMETDCPEPTARPEIDSSSLEGRNVTLRWSLI----GRF--REASGFLVQLYGPYGE 575

  Fly   487 EAPETIYFLNVTWIDQQRLSH-------VRVINV---------HLVHGRPENTSCELKVKSRSQT 535
            :..|...||||..:....|.:       ||::|.         |.:|...:..|....|::.:.:
Zfish   576 KLWEETTFLNVLSVKLYNLEYHKNYQAVVRLVNCGSHGPPSRPHHIHIYKQGPSSPRNVQADALS 640

  Fly   536 CAQIKYQSQ--------CVRYCGLATGGGSCQWR--GSNSAMFGTRYGSCVPESRYCPDHVCDPL 590
            .:.::.:.|        .|:|        |.:::  |.:|                         
Zfish   641 ISAVRLRWQPPEDPNGGIVKY--------SIEYQPVGQSS------------------------- 672

  Fly   591 EELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKN 655
              |:|.            |...:.|:..:.:.|.:|:.:.:...:..         .|.|.:..:
Zfish   673 --LHPW------------VDTDNGNKTTKDVTSLNGSTLYQFRVRAF---------SKVPGEWSS 714

  Fly   656 ETEAE-PLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFV-----ITCPLLFVLLLLCLL 714
            ..:|: |..|:....|..|.:..|:..          |...:|.|     :|| :..:|.||.|.
Zfish   715 FVQAQTPGEGLSSFIPTTQQVGRPLAE----------DHQLLFAVVGSVAVTC-VTILLALLALF 768

  Fly   715 IAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGF-----RFESGDAKWEFP---REKL 771
            ..::.:|:||   ::.|.       :||.|:..::...||.     |.:.......:|   .|.:
Zfish   769 YIRKSVLKRR---RTFTY-------QSGSGEETILQFNSGTLTLTRRPKPSPEPLTYPILEWEDI 823

  Fly   772 QLDTVLGEGEFGQVLKGFATEIAGLPGI-TTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNV 834
            :.:.|:|||.||||:|....:    .|| .:.|:||||:.::..::.....|.::|.:: .|.|:
Zfish   824 KFEDVIGEGNFGQVIKAMVKK----DGIKMSAAIKMLKEFASENDHRDFAGELEVLCKLGQHTNI 884

  Fly   835 IKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVE-----PVNVKMVLTFAWQ 894
            |.|:|||.:.....:.||||.||:|..:||.||.:|   .|.|...|     .:..:.:|.||..
Zfish   885 INLIGACENRGYLYIAIEYAPYGNLLDFLRKSRVLE---TDPAFAKEHGTASTLTSQQLLQFAAD 946

  Fly   895 ICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPES 959
            :..||.|||:.:.:||||||||||:.|..:.||:||||:|.   ::.|:|::..|:||:|||.||
Zfish   947 VATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRG---EEVYVKKTMGRLPVRWMAIES 1008

  Fly   960 LADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTC 1024
            |...|||:||||||||||.||:::||.:||.|:....|:..|..||||::|.||.:.||.::|.|
Zfish  1009 LNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQC 1073

  Fly  1025 WADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDS 1070
            |.|.|..||.|..::.:..::......|:::.  ...|..|.|.|:
Zfish  1074 WRDRPYERPPFSQISVQLNRMQEARKAYVNMA--LFENFTYAGIDA 1117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 116/285 (41%)
TyrKc 771..1042 CDD:197581 116/277 (42%)
tie1XP_001334673.5 EGF_CA <219..244 CDD:238011
IG_like 346..431 CDD:214653 23/130 (18%)
fn3 <461..508 CDD:278470 7/46 (15%)
fn3 538..616 CDD:278470 16/83 (19%)
FN3 628..720 CDD:238020 17/147 (12%)
PKc_like 820..1116 CDD:304357 121/307 (39%)
Pkinase_Tyr 823..1091 CDD:285015 116/277 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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