DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Csf1r

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001025072.1	Gene:	Csf1r / 307403	RGDID:	2425	Length:	1022	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	163/495 - (32%)
Similarity:	236/495 - (47%)	Gaps:	107/495 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   699 VITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPES-GGGDFALM-PLQSGFRFESGD 761
            |:.|..:..||:|.||:...|.      ||......:..:.|| .|.::..: |.|..:     :
  Rat   561 VVACISVMSLLVLLLLLLLYKY------KQKPKYQVRWKIIESYEGNNYTFIDPTQLPY-----N 614

  Fly   762 AKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLL 826
            .||||||..||....||.|.||:|::..|..:.....:..|||||||..:::.|..||:||.:::
  Rat   615 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIM 679

  Fly   827 QEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIEC------------------- 871
            ..: .|.|::.||||||.....|:|.||..||.|.::||  ||.|.
  Rat   680 SHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR--RKAEAMLGPSLSPGQDPEGDSSYK 742

  Fly   872 -----------------AGVDFADGVEPVNVKM---------------------VLTFAWQICKG 898
                             .|||....:.||:...                     :|.|:.|:.:|
  Rat   743 NIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFFKQDLDKEASRPLELWDLLHFSSQVAQG 807

  Fly   899 MAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADH 963
            ||:|:....:|||:|||||||..|.:.||.||||.||:..|..|:.:...|:|||||||||:.|.
  Rat   808 MAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDC 872

  Fly   964 VYTSKSDVWSFGVLCWELITLGASPYPGIAPQN-LWSLLKTGYRMDRPENCSEAVYSIVRTCWAD 1027
            |||.:|||||:|:|.||:.:||.:|||||...| .:.|:|.||:|.:|....|.:|||:::||..
  Rat   873 VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPENIYSIMQSCWDL 937

  Fly  1028 EPNGRPSFK---FLASEFEKLLGNNAKYIDL--ETNAVSNPLYCGDDSALITTELGEPESLQHLW 1087
            ||..||:|:   ||..|..:|......|.:|  .:::.|:....|..|...::|..|..|.:||
  Rat   938 EPTKRPTFQQICFLLQEQARLERREQDYANLPSSSSSSSSSSDSGGGSGGSSSEPEEESSSEHL- 1001

  Fly  1088 SPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLL 1127
                                      :...|| |:.:|||
  Rat  1002 --------------------------ACCEPG-DIAQPLL 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	126/340 (37%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	124/332 (37%)
Csf1r	NP_001025072.1	Ig	69..129	CDD:299845
		IG_like	72..145	CDD:214653
		IG_like	157..239	CDD:214653
		Ig	157..223	CDD:299845
		ig	251..337	CDD:278476
		IG_like	253..339	CDD:214653
		Ig	343..442	CDD:299845
		IG_like	355..439	CDD:214653
		Ig	458..541	CDD:143165
		PTKc_CSF-1R	585..957	CDD:133237	136/378 (36%)
		Pkinase_Tyr	624..948	CDD:285015	122/325 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910