DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and HCK

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_002101.2 Gene:HCK / 3055 HGNCID:4840 Length:526 Species:Homo sapiens


Alignment Length:577 Identity:161/577 - (27%)
Similarity:235/577 - (40%) Gaps:172/577 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   545 CVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIV 609
            |::...|..||.:          |.....|..|   :||.:|.||...:.|              
Human    24 CMKSKFLQVGGNT----------FSKTETSASP---HCPVYVPDPTSTIKP-------------- 61

  Fly   610 GPHSSNENKRGIYSASG--------------------------TCICEDNGKC----SCAPLDEE 644
            ||:|.|.|..||..|..                          ..:.|::|:.    |.|...|.
Human    62 GPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEG 126

  Fly   645 --PKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFV 707
              |.....|....|||.....|:.|.....|                                  
Human   127 YIPSNYVARVDSLETEEWFFKGISRKDAERQ---------------------------------- 157

  Fly   708 LLLLCLLIAQRKMLQRRLGKQSMTTSSKQAL------PESG------------GGDFALMPLQSG 754
                  |:|...||...:.:.|.||....:|      |..|            .|.|.:.| :|.
Human   158 ------LLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISP-RST 215

  Fly   755 F--------RFESG-----------------------DAKWEFPREKLQLDTVLGEGEFGQVLKG 788
            |        .::.|                       || ||.|||.|:|:..||.|:||:|.  
Human   216 FSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDA-WEIPRESLKLEKKLGAGQFGEVW-- 277

  Fly   789 FATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEY 853
                :|.....|.||||.:|.||.|||  |.|:|..:::.:.|..::| |.|..:.|...:|.|:
Human   278 ----MATYNKHTKVAVKTMKPGSMSVE--AFLAEANVMKTLQHDKLVK-LHAVVTKEPIYIITEF 335

  Fly   854 ARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVL 918
            ...|||..:|:            :|......:..::.|:.||.:|||::.:...:||||.|.|:|
Human   336 MAKGSLLDFLK------------SDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANIL 388

  Fly   919 LADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELIT 983
            ::...:|||:||||.| |.||:.|..|...:.|:||.|||::....:|.||||||||:|..|::|
Human   389 VSASLVCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 452

  Fly   984 LGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLAS 1040
            .|..||||::...:...|:.||||.|||||.|.:|:|:..||.:.|..||:|:::.|
Human   453 YGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQS 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 104/271 (38%)
HCKNP_002101.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
SH3 82..137 CDD:473055 7/54 (13%)
SH2_Src_HCK 140..243 CDD:198226 22/143 (15%)
Protein Kinases, catalytic domain 254..524 CDD:473864 110/279 (39%)
Blue background indicates that the domain is not in the aligned region.

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