DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and ret

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_858048.2 Gene:ret / 30512 ZFINID:ZDB-GENE-980526-307 Length:1106 Species:Danio rerio


Alignment Length:1244 Identity:365/1244 - (29%)
Similarity:561/1244 - (45%) Gaps:262/1244 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MESTT-IVFVTLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDNR 64
            |.||. ||:..||.::::    .:..:|||......|:.:.::..|     ||  .||:.|.:..
Zfish     1 MGSTRGIVWGVLLLLLSE----GSFGLYFPQRLYTENIYVGQQQGS-----PL--LQVISMREFP 54

  Fly    65 LASDYLYSLEQNPL----LRINSSSGEIYMR-----TDYRSPNSSATFLVTAFPRDQPDHELLNV 120
            ....|.:.......    ..|:.:||.:|:.     :|:.|..|.:    ...|:|         
Zfish    55 TERPYFFLCSHRDAFTSWFHIDEASGVLYLNKTLEWSDFSSLRSGS----VRSPKD--------- 106

  Fly   121 SHLSLEV----TPQPLEEYCS----------------------ELEHICFWSSAQYTIAESHGPY 159
              |:|:|    || |::..|:                      ||..:||    ...|:..|...
Zfish   107 --LTLKVGVSSTP-PMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCF----PEKISNPHITE 164

  Fly   160 RRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSS-HFVL--KQNRLYTRQTLDHDELNGLNA 221
            .|    ||..:..|.......:||:.::.|.:.|||| .|.:  ..:.|.....:|.:|....:.
Zfish   165 NR----EPGALRQLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEVYHL 225

  Fly   222 KAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEA-- 284
            .       |.|.|: :.|:..:..|.|.:.:.|.:||.|.:..:.:: |..:|   |...|..  
Zfish   226 D-------IVCMVR-TERNLEEVFRSLHVNIYDEDDNSPYVNGTDTE-DVLVE---FDRSEGTVF 278

  Fly   285 GKKVIYVDKDTLEANAHLVY---AVHNDSHG-LFRPDC---HAYEADHTGRPH---------TIV 333
            |...:| |:||..     ||   .|.|...| |...|.   :.:..:|..|..         |:.
Zfish   279 GTLFVY-DRDTTP-----VYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFREEKAIFGNVRGTVH 337

  Fly   334 SCQLRFSRN-GVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLR 397
            ..:|:.|:| .|..:..:.:.....|.|.      ......|..|.|::.|         .:|:|
Zfish   338 EYKLKLSQNLSVTEQRSFLLGYLVNDTTF------PGPEGTVLLHFNVTVL---------PVPIR 387

  Fly   398 ARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVE 462
                       |:..:...::|.....|.:...|.......|:.:.....|::     :..:|..
Zfish   388 -----------FSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLEI-----VDRNITA 436

  Fly   463 DKLGAFGITS-------TSGIVFVKNPQVLEEAPE--TIYFLNVTWIDQQRLSHVRVINVHLVHG 518
            :....:...|       .:|:::|.:.:||.. ||  .:.::.:....|.:|.....:.|.. .|
Zfish   437 EAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRR-PECQELEYVVIAQEQQNKLQAKTQLTVSF-QG 499

  Fly   519 RPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCP 583
            ..::...:   :.|...||:.:.:..|....||....|.||||.........||.:|.|....||
Zfish   500 EADSLKTD---EPRFPACAEKRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCP 561

  Fly   584 DHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMK 648
            |..||.:|..|...|||||: :..|:|.:  ..:..||.:..|||.|.: |||.|.  .:||   
Zfish   562 DGYCDAIESKNISICPQDCS-SEAIIGGY--ERDLYGIKAGHGTCYCFE-GKCFCE--RDEP--- 617

  Fly   649 KPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCL 713
                                       :|.:           |:..|...:.|..:|..::.:.|
Zfish   618 ---------------------------EDDI-----------CNDMCKTVIATGIILSFIVSVLL 644

  Fly   714 L---------------IAQRKMLQRRLGKQSMTTSS----KQALPESGGGDFALMPLQSGFRFES 759
            .               ||..:|..||..:....:.|    ::|..:|.....|:    ..|:...
Zfish   645 SSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDSMENQVAI----DTFKIPE 705

  Fly   760 GDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQ 824
             |.||||||:.|.|...|||||||:|:|..|..:.|..|.|||||||||:.::..|...|||||.
Zfish   706 -DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFT 769

  Fly   825 LLQEVSHPNVIKLLGACTSSEAPL-LIIEYARYGSLRSYLRLSRKI--ECAGVD------FADGV 880
            ||::|:||:|||:.||| |.:.|| ||:|||:|||||::||.|||:  ...|.|      :.:..
Zfish   770 LLKQVNHPHVIKMYGAC-SQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENP 833

  Fly   881 EPVNVKM--VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYL 943
            :...:.|  :::|||||.:||.||:|:|||||||||||||:|:|:..|||||||:|||||:|:|:
Zfish   834 DERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYV 898

  Fly   944 KRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMD 1008
            |||:.|:||||||.|||.||:||::|||||||||.||::|||.:|||||||:.|::||||||||:
Zfish   899 KRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRME 963

  Fly  1009 RPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALI 1073
            :||||::.:|:::..||..|.:.||:|..::.|.||::..:..|:||..:..::.|...|..:..
Zfish   964 KPENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEE 1028

  Fly  1074 TTELGE------PESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATAN 1132
            .|.|.:      |.:|...|...|:      ...||....|:.||          |...|||| |
Zfish  1029 DTPLVDCSNAPLPRTLPSTWIENKL------YGMSYPNWPEKSPV----------PLNRLDAT-N 1076

  Fly  1133 GQVLRYEND 1141
            ....||.||
Zfish  1077 PVFTRYAND 1085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 161/289 (56%)
TyrKc 771..1042 CDD:197581 158/281 (56%)
retNP_858048.2 CA 186..256 CDD:214520 18/77 (23%)
PTKc_RET 715..1004 CDD:173631 161/289 (56%)
Pkinase_Tyr 716..997 CDD:285015 158/281 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170580544
Domainoid 1 1.000 317 1.000 Domainoid score I1243
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 431 1.000 Inparanoid score I1696
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D153428at2759
OrthoFinder 1 1.000 - - FOG0008389
OrthoInspector 1 1.000 - - oto39002
orthoMCL 1 0.900 - - OOG6_108073
Panther 1 1.100 - - LDO PTHR24416
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4355
SonicParanoid 1 1.000 - - X6379
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.930

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