Protein Alignment Ret and ret

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_858048.2
• Gene: ret / 30512
• ZFINID: ZDB-GENE-980526-307
• Length: 1106
• Species: Danio rerio
• Alignment Length: 1244
• Identity: 365/1244 - (29%)
• Similarity: 561/1244 - (45%)
• Gaps: 262/1244 - (21%)

  Fly     1 MESTT-IVFVTLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDNR 64
            |.||. ||:..||.::::    .:..:|||......|:.:.::..|     ||  .||:.|.:..
Zfish     1 MGSTRGIVWGVLLLLLSE----GSFGLYFPQRLYTENIYVGQQQGS-----PL--LQVISMREFP 54

  Fly    65 LASDYLYSLEQNPL----LRINSSSGEIYMR-----TDYRSPNSSATFLVTAFPRDQPDHELLNV 120
            ....|.:.......    ..|:.:||.:|:.     :|:.|..|.:    ...|:|
Zfish    55 TERPYFFLCSHRDAFTSWFHIDEASGVLYLNKTLEWSDFSSLRSGS----VRSPKD--------- 106

  Fly   121 SHLSLEV----TPQPLEEYCS----------------------ELEHICFWSSAQYTIAESHGPY 159
              |:|:|    || |::..|:                      ||..:||    ...|:..|...
Zfish   107 --LTLKVGVSSTP-PMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCF----PEKISNPHITE 164

  Fly   160 RRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSS-HFVL--KQNRLYTRQTLDHDELNGLNA 221
            .|    ||..:..|.......:||:.::.|.:.|||| .|.:  ..:.|.....:|.:|....:.
Zfish   165 NR----EPGALRQLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEVYHL 225

  Fly   222 KAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEA-- 284
            .       |.|.|: :.|:..:..|.|.:.:.|.:||.|.:..:.:: |..:|   |...|..
Zfish   226 D-------IVCMVR-TERNLEEVFRSLHVNIYDEDDNSPYVNGTDTE-DVLVE---FDRSEGTVF 278

  Fly   285 GKKVIYVDKDTLEANAHLVY---AVHNDSHG-LFRPDC---HAYEADHTGRPH---------TIV 333
            |...:| |:||..     ||   .|.|...| |...|.   :.:..:|..|..         |:.
Zfish   279 GTLFVY-DRDTTP-----VYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFREEKAIFGNVRGTVH 337

  Fly   334 SCQLRFSRN-GVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLR 397
            ..:|:.|:| .|..:..:.:.....|.|.      ......|..|.|::.|         .:|:|
Zfish   338 EYKLKLSQNLSVTEQRSFLLGYLVNDTTF------PGPEGTVLLHFNVTVL---------PVPIR 387

  Fly   398 ARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVE 462
                       |:..:...::|.....|.:...|.......|:.:.....|::     :..:|..
Zfish   388 -----------FSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLEI-----VDRNITA 436

  Fly   463 DKLGAFGITS-------TSGIVFVKNPQVLEEAPE--TIYFLNVTWIDQQRLSHVRVINVHLVHG 518
            :....:...|       .:|:::|.:.:||.. ||  .:.::.:....|.:|.....:.|.. .|
Zfish   437 EAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRR-PECQELEYVVIAQEQQNKLQAKTQLTVSF-QG 499

  Fly   519 RPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCP 583
            ..::...:   :.|...||:.:.:..|....||....|.||||.........||.:|.|....||
Zfish   500 EADSLKTD---EPRFPACAEKRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCP 561

  Fly   584 DHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMK 648
            |..||.:|..|...|||||: :..|:|.:  ..:..||.:..|||.|.: |||.|.  .:||
Zfish   562 DGYCDAIESKNISICPQDCS-SEAIIGGY--ERDLYGIKAGHGTCYCFE-GKCFCE--RDEP--- 617

  Fly   649 KPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCL 713
                                       :|.:           |:..|...:.|..:|..::.:.|
Zfish   618 ---------------------------EDDI-----------CNDMCKTVIATGIILSFIVSVLL 644

  Fly   714 L---------------IAQRKMLQRRLGKQSMTTSS----KQALPESGGGDFALMPLQSGFRFES 759
            .               ||..:|..||..:....:.|    ::|..:|.....|:    ..|:...
Zfish   645 SSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDSMENQVAI----DTFKIPE 705

  Fly   760 GDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQ 824
             |.||||||:.|.|...|||||||:|:|..|..:.|..|.|||||||||:.::..|...|||||.
Zfish   706 -DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFT 769

  Fly   825 LLQEVSHPNVIKLLGACTSSEAPL-LIIEYARYGSLRSYLRLSRKI--ECAGVD------FADGV 880
            ||::|:||:|||:.||| |.:.|| ||:|||:|||||::||.|||:  ...|.|      :.:..
Zfish   770 LLKQVNHPHVIKMYGAC-SQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENP 833

  Fly   881 EPVNVKM--VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYL 943
            :...:.|  :::|||||.:||.||:|:|||||||||||||:|:|:..|||||||:|||||:|:|:
Zfish   834 DERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYV 898

  Fly   944 KRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMD 1008
            |||:.|:||||||.|||.||:||::|||||||||.||::|||.:|||||||:.|::||||||||:
Zfish   899 KRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRME 963

  Fly  1009 RPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALI 1073
            :||||::.:|:::..||..|.:.||:|..::.|.||::..:..|:||..:..::.|...|..:..
Zfish   964 KPENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEE 1028

  Fly  1074 TTELGE------PESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATAN 1132
            .|.|.:      |.:|...|...|:      ...||....|:.||          |...|||| |
Zfish  1029 DTPLVDCSNAPLPRTLPSTWIENKL------YGMSYPNWPEKSPV----------PLNRLDAT-N 1076

  Fly  1133 GQVLRYEND 1141
            ....||.||
Zfish  1077 PVFTRYAND 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	161/289 (56%)
ret	NP_858048.2	RET_CLD1	23..140	CDD:465485	27/139 (19%)
		CA	186..256	CDD:214520	18/77 (23%)
		RET_CLD3	251..364	CDD:465516	26/122 (21%)
		RET_CLD4	388..499	CDD:465517	17/117 (15%)
		PTKc_RET	715..1004	CDD:173631	161/289 (56%)