DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and Abl2

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_001382059.1 Gene:Abl2 / 304883 RGDID:1590898 Length:1182 Species:Rattus norvegicus


Alignment Length:501 Identity:155/501 - (30%)
Similarity:229/501 - (45%) Gaps:94/501 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            |||..|..:.:...||.|::|:|..|...:.:     .|||||.||:.:..||  ..|.|..:::
  Rat   280 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYS-----LTVAVKTLKEDTMEVE--EFLKEAAVMK 337

  Fly   828 EVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892
            |:.|||:::|||.||......::.||..||:|..|||     ||:.       |.|...::|..|
  Rat   338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR-----ECSR-------EEVTAVVLLYMA 390

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .||...|.||.:...:||||||||.|:.:..:.|::||||:| :...|.|...:..:.|:||.||
  Rat   391 TQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAP 454

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            ||||.:.::.|||||:||||.||:.|.|.||||||....::.||:.||||::||.|...||.::|
  Rat   455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 519

  Fly  1023 TCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSAL---ITTELGEPES-- 1082
            .||...|..||||......||.:.                     .||::   :..|||...|  
  Rat   520 ACWKWSPADRPSFAETHQAFETMF---------------------HDSSISEEVAEELGRTASSS 563

  Fly  1083 -----LQHLWSPPKIAYDIHDQATSYDQSE-----EEMPVTSTAPPGY-----------DLPRPL 1126
                 |..|...|.....:..|..:.:..:     .|:..:|:||.|:           .|||..
  Rat   564 SVVPYLPRLPLLPSKTRTLKKQGENKENLDGGLDASEILASSSAPAGFIRSTQASSGSPALPRKQ 628

  Fly  1127 LDATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKRGRSYLDMTNKSL 1191
            .|.:.: .:|....:..|..: ||.....|:....:.|          :|.||..|:.:|.|   
  Rat   629 RDKSPS-SLLEDAKETCFTRD-RKGGFFSSFMKKRNAP----------MPPKRSSSFREMEN--- 678

  Fly  1192 IPDNLDSREFEKHLSKTISFRFSSLLNLSETKEVS--PGWQAEDAV 1235
                      :.|....::..||.:.:|......|  ||.|..:.|
  Rat   679 ----------QPHKKYELTGNFSPVASLQHADGFSFTPGQQESNLV 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 111/278 (40%)
Abl2NP_001382059.1 SH3_Abl 111..164 CDD:212784
SH2_ABL 169..262 CDD:198189
PTKc_Abl 281..543 CDD:270645 114/281 (41%)
FABD 1063..1182 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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