DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and kita

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_009292910.1	Gene:	kita / 30256	ZFINID:	ZDB-GENE-980526-464	Length:	981	Species:	Danio rerio

Alignment Length:	1231	Identity:	294/1231 - (23%)
Similarity:	454/1231 - (36%)	Gaps:	370/1231 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESTTIVFVTLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDNRL 65
            ||...::|..||.:|.|.....      ||        |..|...:  .:||.....|..:.|
Zfish     1 MEYHCVLFTVLLQLIIQPGRSR------PT--------ITPEGPRL--TVPLYSNFSLHCQSN-- 47

  Fly    66 ASDYLYSLEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQ 130
             |...:..|..|:..:...                         :.|....:|.|:...    ||
Zfish    48 -STVRWQHENRPMRTLKEE-------------------------QRQGQQTILKVNRAG----PQ 82

  Fly   131 PL------EEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPV-------LIGAL-------NS 175
            .|      ||...|...|..:..| :..|:...|:||...|:.|       :|..|       |.
Zfish    83 HLGKYSCREEKTGEKSSIYVYVKA-FLSADPENPFRRTIVFDIVAAEGDTTVIPCLATDPDMKNL 146

  Fly   176 RAAKYLC-----PHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVK 235
            ...|  |     |: ||.||.:..:...|.|..:          |..|.....|.|.|   .|||
Zfish   147 NLQK--CDGQPLPN-SLRYSASLETGVSVEKVRK----------EFEGCYVCVGTLDA---ATVK 195

  Fly   236 LSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANA 300
             |.|.|      |.::|:.  |..|.:.         |.||. :.....|:| :.:...|...|:
Zfish   196 -SGRYQ------LTVRLVP--DAPPPIT---------LGQPQ-RVLLTQGEK-LSLSCSTSNVNS 240

  Fly   301 HLVY----------AVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLE 355
            .:..          :||.:||.|..|..|...|              ..|.:.|..:.....|.|
Zfish   241 DIAVKWKAPNGVNPSVHQNSHLLTEPITHVRTA--------------ILSLSSVTMQDAGNYSCE 291

  Fly   356 ARDLTIVSRVDAMSATANVCY-------HINLSKLHESEQEL--PQALPLRARQHRIFESEEFNG 411
            |        ::....||...:       .||::.:..|.:.:  .::|.||...:...:...|:.
Zfish   292 A--------INEKGTTAKPVWVNIYEKGFINITSVDNSTRRVRAGESLSLRVVMNAYPKPHTFSW 348

  Fly   412 DSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFG------- 469
            ..:|..|: .|.|:   |...|:..:::     .|.|.|:||:     :.|..:..|.
Zfish   349 SYSGVKLT-NTTDH---VITSRTHGNSY-----TSELKLVRLK-----VSESGIYTFSCLNRDAT 399

  Fly   470 ITSTSGIVFVKNPQVLE-EAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRS 533
            |..|..:..:..||::. |.|          ||.|    ||.:    ..|.|
Zfish   400 IRQTFEVHVISKPQIVSYEGP----------IDGQ----VRCV----AEGYP------------- 433

  Fly   534 QTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMAC 598
              ..|||:.     ||.|                         |.|| |.:.:....||.:.:..
Zfish   434 --TPQIKWY-----YCDL-------------------------PHSR-CSNLLNATQEEEDVVTV 465

  Fly   599 PQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLL 663
            .....|.|:  |...|..|......|:..|:...||:.                      ...|.
Zfish   466 TMTNPPFGK--GAVESRLNITKNNYATLECVASANGEI----------------------VYTLF 506

  Fly   664 GVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQ 728
            .:...|.|:: |..|:|:|.:..|                   |:|:|.|::...|.:|    |.
Zfish   507 SISENTVPHE-LFTPLLIGFVAAA-------------------VILVLILIVLTYKYMQ----KP 547

  Fly   729 SMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEI 793
            ......|......|.....:.|.|..:     |.:|||||:||:....||.|.||:|::..|..:
Zfish   548 KYQIQWKVIEGIHGNNYVYIDPTQLPY-----DHQWEFPRDKLRFGKTLGSGAFGKVVEATAYGM 607

  Fly   794 AGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYG 857
            :....:.||||||||..:::.|..||:||.::|..: :|.|::.||||||.....|:|.||..:|
Zfish   608 SKADTVMTVAVKMLKPSAHATEKEALMSELKVLSYLGNHINIVNLLGACTVGGPTLVITEYCCFG 672

  Fly   858 SLRSYLR---------------------------------LSRKIECAGV--------------- 874
            .|.::||                                 ::.|....|:
Zfish   673 DLLNFLRRRRVYFYYTTLGEDAYYRNVMMQSEPNDSRNGYMTMKPSVLGILSSENRRSLNKGDSY 737

  Fly   875 DFADGVEPV--------NVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFG 931
            ..:|.|..:        :.:.:|:|::|:.|||.:|:....:||||||||:||..|::.||.|||
Zfish   738 SDSDAVSEILQEDGLTLDTEDLLSFSYQVAKGMDFLASKNCIHRDLAARNILLTQGRVAKICDFG 802

  Fly   932 LTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-APQ 995
            |.||:..|..|:.:...|:|||||:|||:.:.|||.:|||||:|:|.||:.:||:|||||: ...
Zfish   803 LARDITTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIFSLGSSPYPGMPVDS 867

  Fly   996 NLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAV 1060
            ..:.::|.||||:.||.....:|.|:.:||..:|..||||..:..:.|:.:.::.|:|
Zfish   868 KFYKMIKEGYRMESPEFSPSEMYDIMHSCWDADPVKRPSFSKIVEKIEQQISDSTKHI------- 925

  Fly  1061 SNPLYCGDDSALITTELGEPESLQHLWSPPKIAYDIHDQATS---------YDQSEEEMPV 1112
                |....|.|........||..|:.....:.  .|..||.         .|:|....||
Zfish   926 ----YLNFSSRLPAAPGPREESSSHVHRLNSVG--SHSTATQPLLSSNDVFLDRSSPSHPV 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	116/336 (35%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	114/328 (35%)
kita	XP_009292910.1	IG_like	123..203	CDD:214653	25/102 (25%)
		IG_like	218..307	CDD:214653	20/112 (18%)
		ig	218..297	CDD:278476	18/102 (18%)
		Ig	311..410	CDD:299845	22/112 (20%)
		IG_like	325..408	CDD:214653	19/96 (20%)
		PTKc_Kit	549..918	CDD:270682	126/373 (34%)
		Pkinase_Tyr	585..914	CDD:285015	114/328 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910