Protein Alignment Ret and Fer

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001382687.1
• Gene: Fer / 301737
• RGDID: 1306273
• Length: 823
• Species: Rattus norvegicus
• Alignment Length: 990
• Identity: 223/990 - (22%)
• Similarity: 364/990 - (36%)
• Gaps: 296/990 - (29%)

  Fly   133 EEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSH 197
            :||...|:::|.......|:..::.....|.:   :|:.....:.::.:..|..   .||:|..|
  Rat    40 KEYAYTLQNLCNQVDKDSTVQVNYVSNVSKSW---LLMIQQTEQLSRIMKTHAE---DLNSGPLH 98

  Fly   198 FVLKQNRLYTRQTLDHDELN----GLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDN 258
                  || |....|..::.    |::.   |::|.:   :|::..:..|........:.:.|..
  Rat    99 ------RL-TMMIKDKQQVKKSYVGIHQ---QIEAEM---IKVTKTELEKLKSSYRQLIKEMNSA 150

  Fly   259 GPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHND-SHGLFRPDCHAYE 322
            ..|.:|:.:|            .:|..|.....||.|::     ::.:||. ...|.....|..:
  Rat   151 KEKYKEALAK------------GKETEKAKERCDKATMK-----LHMLHNQYVLALKGAQLHQSQ 198

  Fly   323 ADHTGRPHTIVSCQ-----LRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSK 382
            ...|..|..:.|.|     :..:..|:|.|.....||...::                  :|:.|
  Rat   199 YYDTTLPLLLDSVQKMQEEMIKALKGIFDEYSEITSLVTEEI------------------VNVHK 245

  Fly   383 LHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSF 447
              |.:..:.|.                          .|:.:|:..:.|:|:.|:..:.::.|:.
  Rat   246 --EIQMSVDQI--------------------------DPSTEYNDFIDVHRTTAAKEQEIEFDTS 282

  Fly   448 L----DLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHV 508
            |    :.::...|.::         .:|:.|..|.:|.  :.||..:|          ||.|.|.
  Rat   283 LLEENENLQANEIMWN---------NLTADSLQVMLKT--LAEELTQT----------QQMLLHK 326

  Fly   509 RVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYG 573
            ....:.|          |.:::..|:|||:   :|..|...|..
  Rat   327 EAAVLEL----------EKRIEESSETCAK---KSDIVLLLGQK--------------------- 357

  Fly   574 SCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSC 638
                          ..||||........||.| :........|.|          :.|::||
  Rat   358 --------------QALEELKQSVQQLRCTEA-KCAAQKELLEQK----------VQENDGK--- 394

  Fly   639 APLDEEPKM--------------KKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGF 689
                |.|.:              :|.|..|.|:....:.|:         ::.|.     :|.|.
  Rat   395 ----EPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGI---------IKSPK-----SVLGS 441

  Fly   690 ECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQ----ALPESGG--GDFAL 748
            ....|.:..|...||           |:.......:.:.......||    .:.||.|  |::.|
  Rat   442 STQLSDVISVGEKPL-----------AEHDWYHGAIPRIEAQELLKQQGDFLVRESHGKPGEYVL 495

  Fly   749 MPLQSG-------------FRFE------------------------SG---------DAKWEFP 767
            .....|             :|||                        ||         |.||...
  Rat   496 SVYSDGQRRHFIIQFVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKDKKWVLN 560

  Fly   768 REKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHP 832
            .|.:.|..:||:|.||:|.||      .|...|.||||..|:.......:..|.|.::|::..||
  Rat   561 HEDVSLGELLGKGNFGEVYKG------TLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHP 619

  Fly   833 NVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICK 897
            |::||:|.||..:...:|:|....|...|:|| .||.|            :.:|.::.|:..:..
  Rat   620 NIVKLIGVCTQRQPVYIIMELVPGGDFLSFLR-KRKDE------------LKLKQLVRFSLDVAA 671

  Fly   898 GMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYED-DAYLKRSRDRVPVKWMAPESLA 961
            ||.||.....:||||||||.|:.:....||||||::|.  || ..|......::|:||.|||:|.
  Rat   672 GMLYLEGKNCIHRDLAARNCLVGENNTLKISDFGMSRQ--EDGGVYSSSGLKQIPIKWTAPEALN 734

  Fly   962 DHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWA 1026
            ...|:|:|||||||:|.||..:||..||||:..|.....::.||||..|:||.|.:::|:..||.
  Rat   735 YGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEIFTIMMKCWD 799

  Fly  1027 DEPNGRPSFKFLASE 1041
            .:|..||.|..|..|
  Rat   800 YKPENRPKFSDLHKE 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	104/273 (38%)
Fer	NP_001382687.1	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		55/350 (16%)
		F-BAR_Fer	5..238	CDD:153370	43/233 (18%)
		SH2_Fps_family	454..539	CDD:198224	14/95 (15%)
		Protein Kinases, catalytic domain	567..817	CDD:473864	103/269 (38%)