DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and flt4

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_571020.2 Gene:flt4 / 30121 ZFINID:ZDB-GENE-980526-326 Length:1368 Species:Danio rerio


Alignment Length:1276 Identity:295/1276 - (23%)
Similarity:480/1276 - (37%) Gaps:413/1276 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 SPNSSATFLVTA----------FPRDQPDHELLNVSHLSLEVTP--------------------- 129
            |.::|:.::|..          ||.|.| .||:....|.|..|.                     
Zfish   232 SQHTSSIYVVQVIGLKFYEFKLFPEDSP-VELMQGESLVLNCTALVDFNTGVDFQWDYPGKKENR 295

  Fly   130 ----QPLEEYCSELEHICFWSSAQYTIAESHGPY--------RRKDFFEPVLIGALNSRAAKYLC 182
                |||.....|...|....|.:....:..|.|        .:::....|::         :..
Zfish   296 LASLQPLRNVLDEATEISSILSIRNIHLDDSGYYTCWANTLEMKRELTTVVIV---------HEK 351

  Fly   183 PHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELNG--LNAKAGQLQARITCTVKLSSRDQRKFS 245
            |.:||:|.                          ||  :.||.||...|:  :||:|:....:..
Zfish   352 PFISLDYR--------------------------NGSVIEAKEGQKSVRL--SVKVSAYPSPEIQ 388

  Fly   246 RILDIKLL-DRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKD--TLEANAHLVYAVH 307
            ...:.||: .:|.:..|:|:.|.:.....:|       :||:.::.:...  .||...:....|:
Zfish   389 WYKNGKLISSKNSSRFKVQQHSLQIRDVCKQ-------DAGEYMLVLKNSPAALEKRLNFTLIVN 446

  Fly   308 NDSHGLFRPDCHAYEA-----------------DHTGRPHTIVS--------CQLRFSRNGVFR- 346
                  ..|..|..||                 ...|.|...:|        |.|..:|..:.| 
Zfish   447 ------VPPQIHEKEAAPPTNLYGKGTRQILTCTADGSPPASISWQWRPWSPCDLERTRRALRRR 505

  Fly   347 ----ETPYCVS------------LEARDLTIVSRVDAMSATANVCYHINLS-----------KLH 384
                ::|:|.:            :|:.| |:...||....|.......|.|           |:.
Zfish   506 GGRDQSPFCHNWMDLDPEHAVNPIESID-TLTQMVDGKEKTVGRVVIQNASVPAMYKCLAENKVG 569

  Fly   385 ESEQ-------ELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNF--- 439
            :.|:       .:|:.          |:.|          :.|.....::|:...:..|.||   
Zfish   570 KDERLIYFYVTTIPEG----------FDIE----------MEPSEDPLEQDLVQLKCNADNFTYE 614

  Fly   440 ---------RVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFL 495
                     :.|.|:  ||...|.... ..:|.:| :|..||        |..||:        |
Zfish   615 NLRWYRLDPQTVPPE--LDCKSLHQYA-TFLEGQL-SFQTTS--------NNWVLQ--------L 659

  Fly   496 NVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQW 560
            |:|.|..|               ...|..||  |::|                   .||...|..
Zfish   660 NITNIQLQ---------------DEGNYVCE--VQNR-------------------RTGVKHCHR 688

  Fly   561 RG-SNSAMFGTRYGSCVPESRYCP-DHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYS 623
            :. ...||...||       |:.| :|..:..|.|. |.|..:.||..::    |..::.:.::.
Zfish   689 KYIPVKAMEAPRY-------RHNPTNHTVNVSESLQ-MNCDVEGTPFPQL----SWFKDNQPLHQ 741

  Fly   624 ASGTCICEDNGKCSCAPLDEEPK---MKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLN 685
            .||..:.:.|...|...:.||..   ......:|...::...:.| .|:.....::..:|:|...
Zfish   742 ISGILLQDSNRTLSIQRVREEDAGLYTCSACNQKGCVQSSATVSV-IGSDDKTNVEIVILIGTGV 805

  Fly   686 VAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMP 750
            :|.|       |:|:      :|::.|.:        :|:....:.|.....:.:.|.     :|
Zfish   806 IAIF-------FWVL------LLVIFCNV--------KRVNPADIKTGYLSIIMDPGE-----VP 844

  Fly   751 LQSGFRFESGD-AKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSV 814
            |:....:...| ::||..|::|:|..|||.|.||:|::.............||||||||:|:.:.
Zfish   845 LEEQCEYLPYDSSQWEISRDRLRLGKVLGHGAFGKVIEASIFGHDKKSSANTVAVKMLKEGATAS 909

  Fly   815 EYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLL-IIEYARYGSLRSYLRLSRK--------- 868
            |:.||:||.::|..: :|.||:.||||||....||: |:||.:||:|.::||..|:         
Zfish   910 EHKALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEYCKYGNLSNFLRAKREFFLPYRDRS 974

  Fly   869 ----------IECAGVDFAD------------------GVEPVNVKMVLTFAWQICKGMAYLSEL 905
                      ||......::                  ...|:.::.::.:::|:.:||.:|:..
Zfish   975 PKTQSQVRRMIEAGQASQSEHQPSTSSTNPPRVTVDDLWKTPLTIEDLICYSFQVARGMEFLASR 1039

  Fly   906 KLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSD 970
            |.:||||||||:||::..:.||.||||.||:|:|..|:::...|:|:|||||||:.|.||||:||
Zfish  1040 KCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKGNARLPLKWMAPESIFDKVYTSQSD 1104

  Fly   971 VWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPS 1034
            |||||||.||:.:||||||||| ..::....||.|.||..|:|.|..:|.|:..||..||..||:
Zfish  1105 VWSFGVLLWEIFSLGASPYPGIQIDEDFCKRLKDGTRMRAPDNASPEIYGIMLACWQGEPRERPT 1169

  Fly  1035 FKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGEPESLQHLWSPPKIAYDI--- 1096
            |..|......||..|                                      |.|:|.:::   
Zfish  1170 FPALVEILGDLLQEN--------------------------------------SLPEIPFNVSQS 1196

  Fly  1097 -----HDQATSYDQSEEEMPVT-STAPPGY--------------------------DLPRPLL-- 1127
                 ..||:|...|:||:.:. :|.|..|                          :||..:.  
Zfish  1197 SEDDGFSQASSRPPSQEEIRLACNTLPTRYYNCVPFAGCVMVGPSSTCHSRVKTFEELPMEMTSH 1261

  Fly  1128 -----DATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSE 1163
                 ..|.:|.||..:...||....|.:..|.:.:..::|
Zfish  1262 KTQHDSQTDSGMVLASDELERFEHKHRGAMLTHATTGQSTE 1302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 127/318 (40%)
flt4NP_571020.2 IgI_VEGFR 249..350 CDD:409448 18/110 (16%)
Ig strand A 249..253 CDD:409448 0/3 (0%)
Ig strand A' 260..264 CDD:409448 2/3 (67%)
Ig strand B 266..275 CDD:409448 3/8 (38%)
Ig strand C 282..287 CDD:409448 0/4 (0%)
Ig strand C' 290..292 CDD:409448 0/1 (0%)
Ig strand D 296..304 CDD:409448 3/7 (43%)
Ig strand E 310..318 CDD:409448 1/7 (14%)
Ig strand F 328..334 CDD:409448 1/5 (20%)
Ig strand G 339..345 CDD:409448 0/5 (0%)
Ig 352..445 CDD:472250 25/127 (20%)
Ig strand B 373..377 CDD:409353 1/5 (20%)
Ig strand C 386..390 CDD:409353 0/3 (0%)
Ig strand E 409..413 CDD:409353 1/3 (33%)
Ig strand F 423..428 CDD:409353 0/4 (0%)
Ig strand G 438..441 CDD:409353 0/2 (0%)
IG_like 602..678 CDD:214653 25/112 (22%)
Ig strand B 602..606 CDD:409353 0/3 (0%)
Ig strand C 615..619 CDD:409353 0/3 (0%)
Ig strand E 657..661 CDD:409353 2/11 (18%)
Ig strand F 671..676 CDD:409353 3/6 (50%)
I-set 705..786 CDD:400151 16/85 (19%)
Ig strand B 716..720 CDD:409353 2/4 (50%)
Ig strand C 729..733 CDD:409353 1/7 (14%)
Ig strand E 752..756 CDD:409353 0/3 (0%)
Ig strand F 766..771 CDD:409353 0/4 (0%)
Ig strand G 779..782 CDD:409353 0/2 (0%)
VEGFR-2_TMD 791..825 CDD:375470 9/54 (17%)
Protein Kinases, catalytic domain 858..1184 CDD:473864 130/325 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 978..1007 2/28 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1192..1212 3/19 (16%)

Return to query results.
Submit another query.