DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and flt4

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_571020.2 Gene:flt4 / 30121 ZFINID:ZDB-GENE-980526-326 Length:1368 Species:Danio rerio


Alignment Length:1276 Identity:295/1276 - (23%)
Similarity:480/1276 - (37%) Gaps:413/1276 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 SPNSSATFLVTA----------FPRDQPDHELLNVSHLSLEVTP--------------------- 129
            |.::|:.::|..          ||.|.| .||:....|.|..|.                     
Zfish   232 SQHTSSIYVVQVIGLKFYEFKLFPEDSP-VELMQGESLVLNCTALVDFNTGVDFQWDYPGKKENR 295

  Fly   130 ----QPLEEYCSELEHICFWSSAQYTIAESHGPY--------RRKDFFEPVLIGALNSRAAKYLC 182
                |||.....|...|....|.:....:..|.|        .:::....|::         :..
Zfish   296 LASLQPLRNVLDEATEISSILSIRNIHLDDSGYYTCWANTLEMKRELTTVVIV---------HEK 351

  Fly   183 PHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELNG--LNAKAGQLQARITCTVKLSSRDQRKFS 245
            |.:||:|.                          ||  :.||.||...|:  :||:|:....:..
Zfish   352 PFISLDYR--------------------------NGSVIEAKEGQKSVRL--SVKVSAYPSPEIQ 388

  Fly   246 RILDIKLL-DRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKD--TLEANAHLVYAVH 307
            ...:.||: .:|.:..|:|:.|.:.....:|       :||:.::.:...  .||...:....|:
Zfish   389 WYKNGKLISSKNSSRFKVQQHSLQIRDVCKQ-------DAGEYMLVLKNSPAALEKRLNFTLIVN 446

  Fly   308 NDSHGLFRPDCHAYEA-----------------DHTGRPHTIVS--------CQLRFSRNGVFR- 346
                  ..|..|..||                 ...|.|...:|        |.|..:|..:.| 
Zfish   447 ------VPPQIHEKEAAPPTNLYGKGTRQILTCTADGSPPASISWQWRPWSPCDLERTRRALRRR 505

  Fly   347 ----ETPYCVS------------LEARDLTIVSRVDAMSATANVCYHINLS-----------KLH 384
                ::|:|.:            :|:.| |:...||....|.......|.|           |:.
Zfish   506 GGRDQSPFCHNWMDLDPEHAVNPIESID-TLTQMVDGKEKTVGRVVIQNASVPAMYKCLAENKVG 569

  Fly   385 ESEQ-------ELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNF--- 439
            :.|:       .:|:.          |:.|          :.|.....::|:...:..|.||   
Zfish   570 KDERLIYFYVTTIPEG----------FDIE----------MEPSEDPLEQDLVQLKCNADNFTYE 614

  Fly   440 ---------RVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFL 495
                     :.|.|:  ||...|.... ..:|.:| :|..||        |..||:        |
Zfish   615 NLRWYRLDPQTVPPE--LDCKSLHQYA-TFLEGQL-SFQTTS--------NNWVLQ--------L 659

  Fly   496 NVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQW 560
            |:|.|..|               ...|..||  |::|                   .||...|..
Zfish   660 NITNIQLQ---------------DEGNYVCE--VQNR-------------------RTGVKHCHR 688

  Fly   561 RG-SNSAMFGTRYGSCVPESRYCP-DHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYS 623
            :. ...||...||       |:.| :|..:..|.|. |.|..:.||..::    |..::.:.::.
Zfish   689 KYIPVKAMEAPRY-------RHNPTNHTVNVSESLQ-MNCDVEGTPFPQL----SWFKDNQPLHQ 741

  Fly   624 ASGTCICEDNGKCSCAPLDEEPK---MKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLN 685
            .||..:.:.|...|...:.||..   ......:|...::...:.| .|:.....::..:|:|...
Zfish   742 ISGILLQDSNRTLSIQRVREEDAGLYTCSACNQKGCVQSSATVSV-IGSDDKTNVEIVILIGTGV 805

  Fly   686 VAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMP 750
            :|.|       |:|:      :|::.|.:        :|:....:.|.....:.:.|.     :|
Zfish   806 IAIF-------FWVL------LLVIFCNV--------KRVNPADIKTGYLSIIMDPGE-----VP 844

  Fly   751 LQSGFRFESGD-AKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSV 814
            |:....:...| ::||..|::|:|..|||.|.||:|::.............||||||||:|:.:.
Zfish   845 LEEQCEYLPYDSSQWEISRDRLRLGKVLGHGAFGKVIEASIFGHDKKSSANTVAVKMLKEGATAS 909

  Fly   815 EYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLL-IIEYARYGSLRSYLRLSRK--------- 868
            |:.||:||.::|..: :|.||:.||||||....||: |:||.:||:|.::||..|:         
Zfish   910 EHKALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEYCKYGNLSNFLRAKREFFLPYRDRS 974

  Fly   869 ----------IECAGVDFAD------------------GVEPVNVKMVLTFAWQICKGMAYLSEL 905
                      ||......::                  ...|:.::.::.:::|:.:||.:|:..
Zfish   975 PKTQSQVRRMIEAGQASQSEHQPSTSSTNPPRVTVDDLWKTPLTIEDLICYSFQVARGMEFLASR 1039

  Fly   906 KLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSD 970
            |.:||||||||:||::..:.||.||||.||:|:|..|:::...|:|:|||||||:.|.||||:||
Zfish  1040 KCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKGNARLPLKWMAPESIFDKVYTSQSD 1104

  Fly   971 VWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPS 1034
            |||||||.||:.:||||||||| ..::....||.|.||..|:|.|..:|.|:..||..||..||:
Zfish  1105 VWSFGVLLWEIFSLGASPYPGIQIDEDFCKRLKDGTRMRAPDNASPEIYGIMLACWQGEPRERPT 1169

  Fly  1035 FKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGEPESLQHLWSPPKIAYDI--- 1096
            |..|......||..|                                      |.|:|.:::   
Zfish  1170 FPALVEILGDLLQEN--------------------------------------SLPEIPFNVSQS 1196

  Fly  1097 -----HDQATSYDQSEEEMPVT-STAPPGY--------------------------DLPRPLL-- 1127
                 ..||:|...|:||:.:. :|.|..|                          :||..:.  
Zfish  1197 SEDDGFSQASSRPPSQEEIRLACNTLPTRYYNCVPFAGCVMVGPSSTCHSRVKTFEELPMEMTSH 1261

  Fly  1128 -----DATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSE 1163
                 ..|.:|.||..:...||....|.:..|.:.:..::|
Zfish  1262 KTQHDSQTDSGMVLASDELERFEHKHRGAMLTHATTGQSTE 1302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 127/318 (40%)
TyrKc 771..1042 CDD:197581 125/310 (40%)
flt4NP_571020.2 IG_like 258..348 CDD:214653 15/90 (17%)
Ig1_VEGFR 265..350 CDD:143270 12/93 (13%)
IG_like 362..445 CDD:214653 19/91 (21%)
Ig 373..445 CDD:299845 15/80 (19%)
Ig 602..685 CDD:143165 28/138 (20%)
IG 602..678 CDD:214652 25/112 (22%)
I-set 705..786 CDD:254352 16/85 (19%)
IGc2 714..776 CDD:197706 13/66 (20%)
PKc_like 858..1184 CDD:304357 130/325 (40%)
Pkinase_Tyr 866..1177 CDD:285015 125/310 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 978..1007 2/28 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1190..1212 3/21 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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