Protein Alignment Ret and ZC581.7

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_491913.1
• Gene: ZC581.7 / 266838
• WormBaseID: WBGene00022634
• Length: 395
• Species: Caenorhabditis elegans
• Alignment Length: 343
• Identity: 89/343 - (25%)
• Similarity: 152/343 - (44%)
• Gaps: 68/343 - (19%)

  Fly   735 KQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGI 799
            |:|:|:   |.|.||.....|:.:                  ||.|.:|.|..|..|:     ..
 Worm   105 KRAIPK---GKFQLMHKDVDFKKK------------------LGSGAYGTVYLGRLTK-----NN 143

  Fly   800 TTVAVKMLKKGSNSVEYMA-LLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYL 863
            |.:|||.|....|..|.:| ::.|.:::|...|||::|..|........||::|....||:...|
 Worm   144 TKIAVKKLDTEGNDEESLAEMMKEARVMQLYDHPNIVKFYGYIVDDIPYLLVLELCNGGSVEDKL 208

  Fly   864 RLSRKIECAGVDFADGVE---PVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKIC 925
                            ||   .::.|..:.:.:....|:.||.:.|.:|||:||||.|: ..:|.
 Worm   209 ----------------VEKGAKLSTKTRIMYTYHAACGIEYLHKKKCIHRDIAARNCLI-HKEIV 256

  Fly   926 KISDFGLTR--DVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASP 988
            ||:|||:.|  .:|:.|  |.:..:   .:|:|||...:......:|:::|.:..||...:   |
 Worm   257 KIADFGMCRATSIYKVD--LNKPTN---TRWLAPEVWDNGETRDNTDIFAFAITMWEFFEV---P 313

  Fly   989 YPGIAPQNLW------SLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLG 1047
            |.  :|.:.|      ...:.|||:..|:.....:..|::.||..:||.||:...|..:.|:.:.
 Worm   314 YD--SPYSEWKGYMVKQKTRAGYRLPTPKGMPWDIEEIMKLCWHVDPNQRPTASELREKIEETMA 376

  Fly  1048 ---NNAKYIDLETNAVSN 1062
               ::|..::...:..||
 Worm   377 KPESSATPLNKSKSQTSN 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	78/293 (27%)
ZC581.7	NP_491913.1	SH2	9..97	CDD:472789
		PK_Tyr_Ser-Thr	120..371	CDD:462242	78/300 (26%)