DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Kdr

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_037194.2	Gene:	Kdr / 25589	RGDID:	2965	Length:	1343	Species:	Rattus norvegicus

Alignment Length:	1316	Identity:	312/1316 - (23%)
Similarity:	503/1316 - (38%)	Gaps:	342/1316 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 DYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQPLEEYCSEL-----------EHICFW- 145
            |:..||:         |||..:..|:.....|:         :|..|           .:.||:
  Rat    60 DWLWPNT---------PRDSEERVLVTECGDSI---------FCKTLTVPRVVGNDTGAYKCFYR 106

  Fly   146 ----SSAQYTIAESHGPYRRKDFFEPV-----LIGALNSRAAKYLCPHVSLEYSLNAG------S 195
                ||..|...:.|    |..|...|     ::....::....:.|......:||..      .
  Rat   107 DTDVSSIVYVYVQDH----RSPFIASVSDEHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPE 167

  Fly   196 SHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQ--ARITCTVKLSSRDQRKFS--------RILDI 250
            ..||...||      :..|...|....:..:.  ..:.|..|::....:...        ||.|:
  Rat   168 KRFVPDGNR------ISWDSEKGFTIPSYMISYAGMVFCEAKINDETYQSIMYIVLVVGYRIYDV 226

  Fly   251 KLLDRND----NGPKL-------QESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVY 304
            .|...::    .|.||       .|.:...||..:   |.:.:...||::..|..:|......::
  Rat   227 VLSPPHEIELSAGEKLVLNCTARTELNVGLDFSWQ---FPSSKHQHKKIVNRDVKSLPGTVAKMF 288

  Fly   305 -------AVHNDSHGLFRPDCHAYEADHTGRPHTIV----------------------------- 333
                   :|.....|.:  .|.||....|.:..|.|
  Rat   289 LSTLTIDSVTKSDQGEY--TCTAYSGLMTKKNKTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIP 351

  Fly   334 -------SCQLRFSRNGVFRETPYCVSLEARDLTI--VSRVDAMSATANVCYHINLSK------- 382
                   :..:::.|||...|:.|.: :...:|||  ||..||.:.|..:...|::.|
  Rat   352 VKYLSYPAPDIKWYRNGRPIESNYTM-IVGDELTIMEVSERDAGNYTVILTNPISMEKQSHMVSL 415

  Fly   383 -LHESEQELPQAL--PLRARQHRIFESEEFNGDSAGRSLSPPTVDYD-----KDVSVYRSAASN- 438
             ::...|...:||  |:.:.|:...::.     :.....:||.....     ::...||.:.:|
  Rat   416 VVNVPPQIGEKALISPMDSYQYGTMQTL-----TCTVYANPPLHHIQWYWQLEEACSYRPSQTNP 475

  Fly   439 -----FRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVT 498
                 :|.|:.....:.:.:...::.::|.|    ..|.::.::...|...|.:. |.|
  Rat   476 YTCKEWRHVKDFQGGNKIEVTKNQYALIEGK----NKTVSTLVIQAANVSALYKC-EAI------ 529

  Fly   499 WIDQQRLSHVRVINVHLVHGRPENT----SCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGS-- 557
               .:.....|||:.|::.| ||.|    :...:.:|.|..|...:...:.:.:..|.:...|
  Rat   530 ---NKAGRGERVISFHVIRG-PEITVQPATQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVH 590

  Fly   558 --------CQ-----WRGSNSAMFGTR----------------YGSCV-------PESRYCPDHV 586
                    |:     |: .|..:|...                .|:.|       .:.|:|....
  Rat   591 MGESLTPVCKNLDALWK-LNGTVFSNSTNDILIVAFQNASLQDQGNYVCSAQDKKTKKRHCLVKQ 654

  Fly   587 CDPLEELNPMA---CPQDCTPAG---RIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEP 645
            ...||.:.||.   .....|..|   .:|.|.|.|......:......:.||:|   ....|...
  Rat   655 LVILERMAPMITGNLENQTTTIGETIEVVCPTSGNPTPLITWFKDNETLVEDSG---IVLKDGNR 716

  Fly   646 KMKKPRKRKNE-----TEAEPLLGVRR--------GTPPNQPLQDPMLLGVLNVAGFECDRSCMF 697
            .:...|.||.:     .:|..:||..|        |......|:..:|:|...:|        ||
  Rat   717 NLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVIILVGTAVIA--------MF 773

  Fly   698 FVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGF-RFESGD 761
            |.    ||.|::|..:..|....|  :.|..|:.....:            :||.... |.....
  Rat   774 FW----LLLVIVLRTVKRANEGEL--KTGYLSIVMDPDE------------LPLDERCERLPYDA 820

  Fly   762 AKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLL 826
            :||||||::|:|...||.|.||||::..|..|.......||||||||:|:...|:.||:||.::|
  Rat   821 SKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKIL 885

  Fly   827 QEVSHP-NVIKLLGACTSSEAPLL-IIEYARYGSLRSYLRLSRK----IECAGVDFADGVEPV-- 883
            ..:.|. ||:.||||||....||: |:|:.::|:|.:|||..|.    .:..|..|..|.:.|
  Rat   886 IHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRSGKDYVGE 950

  Fly   884 ----------------------------------------------NVKMVLTFAWQICKGMAYL 902
                                                          .::.::.:::|:.|||.:|
  Rat   951 LSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFL 1015

  Fly   903 SELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTS 967
            :..|.:||||||||:||::..:.||.||||.||:|:|..|:::...|:|:||||||::.|.|||.
  Rat  1016 ASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTI 1080

  Fly   968 KSDVWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNG 1031
            :|||||||||.||:.:||||||||: ..:.....||.|.||..|:..:..:|..:..||.::||.
  Rat  1081 QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQ 1145

  Fly  1032 RPSFKFLASEFEKLLGNNAK-----YIDLETNAVSNPLYCGDDS--ALITTELG--EPESLQHLW 1087
            ||:|..|......||..||:     ||.|   .:|..|...:||  :|.|:.:.  |.|.:
  Rat  1146 RPAFSELVEHLGNLLQANAQQDGKDYIVL---PMSETLSMEEDSGLSLPTSPVSCMEEEEV---- 1203

  Fly  1088 SPPKIAYDIHDQATSYDQS--EEEMPVTSTAPPGYDLPRPLL------DATANGQVLRYENDLRF 1144
            ..||..||.....:.|.|:  .:..||:........|..|.:      ..|.:|.||..| :|:.
  Rat  1204 CDPKFHYDNTAGISHYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDSQTDSGMVLASE-ELKT 1267

  Fly  1145 PLNIRKSSCTPSYSNM 1160
            ..:..|.|  ||:..|
  Rat  1268 LEDRNKLS--PSFGGM 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	124/333 (37%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	122/325 (38%)
Kdr	NP_037194.2	Ig	224..325	CDD:416386	21/105 (20%)
		Ig strand A	224..228	CDD:409353	1/3 (33%)
		Ig strand A'	234..238	CDD:409353	0/3 (0%)
		Ig strand B	240..249	CDD:409353	2/8 (25%)
		Ig strand C	256..261	CDD:409353	2/4 (50%)
		Ig strand C'	264..266	CDD:409353	0/1 (0%)
		Ig strand D	270..278	CDD:409353	3/7 (43%)
		Ig strand E	286..294	CDD:409353	0/7 (0%)
		Ig strand F	304..310	CDD:409353	1/7 (14%)
		Ig strand G	315..321	CDD:409353	1/5 (20%)
		Ig	329..417	CDD:416386	15/88 (17%)
		Ig strand A	329..332	CDD:409353	0/2 (0%)
		Ig strand A'	339..343	CDD:409353	0/3 (0%)
		Ig strand B	345..356	CDD:409353	0/10 (0%)
		Ig strand C	360..366	CDD:409353	0/5 (0%)
		Ig strand C'	368..371	CDD:409353	1/2 (50%)
		Ig strand D	376..379	CDD:409353	0/3 (0%)
		Ig strand E	381..386	CDD:409353	2/4 (50%)
		Ig strand F	394..402	CDD:409353	1/7 (14%)
		Ig strand G	408..417	CDD:409353	1/8 (13%)
		Ig_3	547..641	CDD:404760	14/94 (15%)
		IGc2	676..740	CDD:197706	13/66 (20%)
		Ig strand B	680..684	CDD:409353	0/3 (0%)
		Ig strand C	693..697	CDD:409353	0/3 (0%)
		Ig strand E	716..720	CDD:409353	0/3 (0%)
		Ig strand F	730..735	CDD:409353	0/4 (0%)
		VEGFR-2_TMD	755..789	CDD:375470	11/45 (24%)
		PTKc_VEGFR2	822..1163	CDD:270681	130/340 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1314		5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910