Protein Alignment Ret and FYN

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_002028.1
• Gene: FYN / 2534
• HGNCID: 4037
• Length: 537
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 110/297 - (37%)
• Similarity: 167/297 - (56%)
• Gaps: 27/297 - (9%)

  Fly   749 MPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNS 813
            ||..:....::.|. ||.|||.|||...||.|:||:|..|...      |.|.||:|.||.|:.|
Human   250 MPRLTDLSVKTKDV-WEIPRESLQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTLKPGTMS 307

  Fly   814 VEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFA 877
            .|  :.|.|.|:::::.|..:::|....  ||.|:.|: ||...|||..:|:
Human   308 PE--SFLEEAQIMKKLKHDKLVQLYAVV--SEEPIYIVTEYMNKGSLLDFLK------------- 355

  Fly   878 DGV-EPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDA 941
            ||. ..:.:..::..|.|:..||||:..:..:||||.:.|:|:.:|.||||:||||.| :.||:.
Human   356 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLAR-LIEDNE 419

  Fly   942 YLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYR 1006
            |..|...:.|:||.|||:.....:|.||||||||:|..||:|.|..||||:..:.:...::.|||
Human   420 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYR 484

  Fly  1007 MDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            |..|::|..:::.::..||..:|..||:|::|.|..|
Human   485 MPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	102/276 (37%)
FYN	NP_002028.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281
		PTKc_Fyn	261..534	CDD:270655	108/286 (38%)