DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Pdgfra

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_036934.1	Gene:	Pdgfra / 25267	RGDID:	3284	Length:	1088	Species:	Rattus norvegicus

Alignment Length:	1080	Identity:	266/1080 - (24%)
Similarity:	416/1080 - (38%)	Gaps:	290/1080 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 YLEQPYFQADEEAGKKV-IYV-DKD----TLEANAHLVYAVHNDSHGLFRPDCHAYEAD-----H 325
            |......:..|..|:.: ||| |.|    .|.....||....:||..:   .|...:.|     |
  Rat   100 YYNHTQTEESEIEGRHIYIYVPDPDMAFVPLGMTDSLVIVEEDDSAII---PCRTTDPDTEVTLH 161

  Fly   326 TGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVS---RVDAMSATANVCYH---------- 377
            ........|...|...||.|...||......|..|..:   .|.|:.||:.:...
  Rat   162 NNGRLVPASYDSRQGFNGTFSVGPYICEATVRGRTFKTSEFNVYALKATSELNLEMDTRQTVYKA 226

  Fly   378 -----INLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAG--RSLSPP--TVDYDKDVSVYR 433
                 :..:..:....:|....|...|...|...||....|..  .:|:.|  ||   ||...|.
  Rat   227 GETIVVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVYTLTVPKATV---KDSGDYE 288

  Fly   434 SAA-------------------SNFRVVQPD-SFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVF 478
            .||                   ..|..::|. ..|:.:.|..:|..:||  :.|:   .|..|.:
  Rat   289 CAARQATKEVKEMKTVTISVHEKGFVQIRPTFGHLETVNLHQVREFVVE--VQAY---PTPRISW 348

  Fly   479 VKNPQVLEEAPETIYFLNVTWI--DQQRLSHVRV-INVHLVHGRPENTSCELKVKSRSQTCAQIK 540
            :|:...|.|        |:|.|  |.||....|. ..:.|:..:.|::.....:...........
  Rat   349 LKDNLTLIE--------NLTEITTDVQRSQETRYQSKLKLIRAKEEDSGHYTIIVQNDDDMKSYT 405

  Fly   541 YQSQCVRYCGL--------ATGGGS---CQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELN 594
            ::...:....:        .:|||.   |           |..|:.:|...:.   :|..:::
  Rat   406 FELSTLVPASILELVDDHHGSGGGQTVRC-----------TAEGTPLPNIEWM---ICKDIKK-- 454

  Fly   595 PMACPQDCTPAGRIVGPHSSN----ENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKN 655
               |..|  .:..::..:.||    .::||..:.        .|:.|.|.::|...::  ...||
  Rat   455 ---CNND--TSWTVLASNVSNIITEFHQRGRSTV--------EGRVSFAKVEETIAVR--CLAKN 504

  Fly   656 ETEAEPLLGVRRGTPPNQPLQ--DPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQR 718
            :      ||:     .|:.|:  .|.|...|.||.          .:...|:.|::.|.:|:.
  Rat   505 D------LGI-----GNRELKLVAPTLRSELTVAA----------AVLVLLVIVIVSLIVLVV-- 546

  Fly   719 KMLQRRLGKQSMTTSSKQALPES---GGGDFALM-PLQSGFRFESGDAKWEFPREKLQLDTVLGE 779
                  :.||......:..:.||   .|.::..: |:|..:     |::|||||:.|.|..:||.
  Rat   547 ------IWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPY-----DSRWEFPRDGLVLGRILGS 600

  Fly   780 GEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HPNVIKLLGACTS 843
            |.||:|::|.|..::....:..|||||||..:.|.|..||:||.:::..:. |.|::.||||||.
  Rat   601 GAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK 665

  Fly   844 SEAPLLIIEYARYGSLRSYLRLSR-------------KIECAGVDFADGV--------------- 880
            |....:|.||..||.|.:||..:|             .::..|::.||..
  Rat   666 SGPIYIITEYCFYGDLVNYLHKNRDSFMSRHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDY 730

  Fly   881 --------------------------------EPVNVKM------------------------VL 889
                                            .|.:.|.                        :|
  Rat   731 VDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEAKNLLSDDDSEGLTLLDLL 795

  Fly   890 TFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKW 954
            :|.:|:.:||.:|:....|||||||||||||.|||.||.||||.||:..|..|:.:....:||||
  Rat   796 SFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKW 860

  Fly   955 MAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPG-IAPQNLWSLLKTGYRMDRPENCSEAVY 1018
            |||||:.|::||:.|||||:|||.||:.:||.:|||| :.....::.:|:||||.:|::.:..||
  Rat   861 MAPESIFDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVY 925

  Fly  1019 SIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK---------YIDLETNAVSNPLYCGDDSALIT 1074
            .|:..||..||..||||..|:...|.||....|         ::..:..||:......|::.:..
  Rat   926 EIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGV 990

  Fly  1075 TELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYE 1139
            |...|.:.|:. |..     .:.:|..|.|.             ||.:|.|.:|.....:.|...
  Rat   991 TYKNEEDKLKE-WEG-----GLDEQRLSADS-------------GYIIPLPDIDPVPEEEDLGKR 1036

  Fly  1140 NDLRFPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKR 1179
            |               .:|:.|||..|..:....|..:||
  Rat  1037 N---------------RHSSQTSEESAIETGSSSSTFIKR 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	127/364 (35%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	124/356 (35%)
Pdgfra	NP_036934.1	Ig_3	27..99	CDD:404760
		Ig	211..309	CDD:416386	16/100 (16%)
		Ig strand A	211..215	CDD:409353	0/3 (0%)
		Ig strand A'	222..226	CDD:409353	0/3 (0%)
		Ig strand B	228..237	CDD:409353	0/8 (0%)
		Ig strand C	242..247	CDD:409353	1/4 (25%)
		Ig strand C'	250..252	CDD:409353	0/1 (0%)
		Ig strand D	256..264	CDD:409353	3/7 (43%)
		Ig strand E	268..276	CDD:409353	1/7 (14%)
		Ig strand F	286..292	CDD:409353	2/5 (40%)
		Ig strand G	297..303	CDD:409353	0/5 (0%)
		Ig4_PDGFR	312..412	CDD:409445	22/112 (20%)
		Ig strand B	332..336	CDD:409445	1/3 (33%)
		Ig strand C	345..349	CDD:409445	1/3 (33%)
		Ig strand E	376..380	CDD:409445	0/3 (0%)
		Ig strand F	390..395	CDD:409445	0/4 (0%)
		Ig strand G	403..406	CDD:409445	0/2 (0%)
		PTKc_PDGFR_alpha	554..955	CDD:173653	138/405 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1088		14/60 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000