Protein Alignment Ret and Fyn

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_006256584.1
• Gene: Fyn / 25150
• RGDID: 2641
• Length: 575
• Species: Rattus norvegicus
• Alignment Length: 297
• Identity: 109/297 - (36%)
• Similarity: 166/297 - (55%)
• Gaps: 27/297 - (9%)

  Fly   749 MPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNS 813
            ||..:....::.|. ||.|||.|||...||.|:||:|..|...      |.|.||:|.||.|:.|
  Rat   288 MPRLTDLSVKTKDV-WEIPRESLQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTLKPGTMS 345

  Fly   814 VEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFA 877
            .|  :.|.|.|:::::.|..:::|....  ||.|:.|: ||...|||..:|:
  Rat   346 PE--SFLEEAQIMKKLKHDKLVQLYAVV--SEEPIYIVTEYMNKGSLLDFLK------------- 393

  Fly   878 DGV-EPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDA 941
            ||. ..:.:..::..|.|:..||||:..:..:||||.:.|:|:.:|.||||:||||.| :.||:.
  Rat   394 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLAR-LIEDNE 457

  Fly   942 YLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYR 1006
            |..|...:.|:||.|||:.....:|.||||||||:|..||:|.|..||||:..:.:...::.|||
  Rat   458 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYR 522

  Fly  1007 MDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            |..|::|..:::.::..||..:|..||:|::|....|
  Rat   523 MPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLE 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/276 (37%)
Fyn	XP_006256584.1	SH3_Fyn_Yrk	123..178	CDD:212939
		SH2_Src_Fyn_isoform_a_like	183..283	CDD:198281
		PTKc_Fyn	299..572	CDD:270655	107/286 (37%)