DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ret and Fgfr2

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_036844.1	Gene:	Fgfr2 / 25022	RGDID:	2611	Length:	841	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	186/543 - (34%)
Similarity:	277/543 - (51%)	Gaps:	108/543 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 GPHSSNENKRGIYSA----SGTCICEDN---GKCS-CAPLDEEPKMKKPRKRKNETEAEPLLGVR 666
            |.:|||.....:::.    :|..||:.:   |:.: .|.|...||.:.| .|:.|..|.|
  Rat   335 GINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAP-VREKEITASP----- 393

  Fly   667 RGTPPNQPLQDPMLLGVLNVAGFECDRSCM-FFVITCPLLFVLLLLCLL---------------- 714
                           ..|.:|.:     |: .|:|.|  :.|.::.|.:
  Rat   394 ---------------DYLEIAIY-----CIGVFLIAC--MVVTVIFCRMKTTTKKPDFSSQPAVH 436

  Fly   715 -IAQRKMLQRRLGKQSMTTSSKQALPE--------SGGGDFALMPLQSGFRFESGDAKWEFPREK 770
             :.:|..|:|::...:.::||..:...        |...|..::...|.:.... |.||||||:|
  Rat   437 KLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPE-DPKWEFPRDK 500

  Fly   771 LQLDTVLGEGEFGQVLKGFATEIAGL-----PGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV- 829
            |.|...||||.||||:   ..|..|:     ....||||||||..:...:...|:||.::::.:
  Rat   501 LTLGKPLGEGCFGQVV---MAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 562

  Fly   830 SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGV-----EPVNVKMVL 889
            .|.|:|.||||||......:|:|||..|:||.|||..|.   .|::::..:     |.:..|.::
  Rat   563 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP---PGMEYSYDINRVPEEQMTFKDLV 624

  Fly   890 TFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKW 954
            :..:|:.:||.||:..|.:||||||||||:.:..:.||:||||.||:...|.|.|.:..|:||||
  Rat   625 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKW 689

  Fly   955 MAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYS 1019
            ||||:|.|.|||.:|||||||||.||:.|||.||||||..:.|:.|||.|:|||:|.||:..:|.
  Rat   690 MAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYM 754

  Fly  1020 IVRTCWADEPNGRPSFKFLASEFEKL--LGNNAKYIDLETNAVS--NPLY------C--GDDSAL 1072
            ::|.||...|:.||:||.|..:.:::  |..|.:|:|| |..:.  :|.|      |  ||||
  Rat   755 MMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL-TQPLEQYSPSYPDTRSSCSSGDDS-- 816

  Fly  1073 ITTELGEPESLQHLWSPPKIAYD 1095
                         ::||..:.||
  Rat   817 -------------VFSPDPMPYD 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	130/291 (45%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	128/281 (46%)
Fgfr2	NP_036844.1	Ig	50..143	CDD:416386
		Ig strand A	50..53	CDD:409353
		Ig strand A'	66..72	CDD:409353
		Ig strand B	75..85	CDD:409353
		Ig strand C	88..93	CDD:409353
		Ig strand C'	96..98	CDD:409353
		Ig strand D	103..107	CDD:409353
		Ig strand E	110..115	CDD:409353
		Ig strand F	121..130	CDD:409353
		Ig strand G	133..143	CDD:409353
		IgI_2_FGFR	173..267	CDD:409443
		Ig strand B	194..198	CDD:409443
		Ig strand C	207..211	CDD:409443
		Ig strand E	233..237	CDD:409443
		Ig strand F	247..252	CDD:409443
		Ig strand G	260..263	CDD:409443
		Ig	275..377	CDD:416386	10/41 (24%)
		Ig strand A	275..278	CDD:409353
		Ig strand A'	282..286	CDD:409353
		Ig strand B	294..301	CDD:409353
		Ig strand C	305..312	CDD:409353
		Ig strand D	327..332	CDD:409353
		Ig strand E	342..347	CDD:409353	0/4 (0%)
		Ig strand F	355..363	CDD:409353	3/7 (43%)
		Ig strand G	366..374	CDD:409353	2/7 (29%)
		FGFR3_TM	391..421	CDD:407957	10/56 (18%)
		PTKc_FGFR2	476..788	CDD:270679	140/318 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910