DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and ABL1

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_009297.2 Gene:ABL1 / 25 HGNCID:76 Length:1149 Species:Homo sapiens


Alignment Length:484 Identity:150/484 - (30%)
Similarity:223/484 - (46%) Gaps:74/484 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            |||..|..:.:...||.|::|:|.:|...:.:     .|||||.||:.:..||  ..|.|..:::
Human   253 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYS-----LTVAVKTLKEDTMEVE--EFLKEAAVMK 310

  Fly   828 EVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892
            |:.|||:::|||.||......:|.|:..||:|..|||     ||       ..:.||..::|..|
Human   311 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR-----EC-------NRQEVNAVVLLYMA 363

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .||...|.||.:...:||||||||.|:.:..:.|::||||:| :...|.|...:..:.|:||.||
Human   364 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAP 427

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            ||||.:.::.|||||:||||.||:.|.|.||||||....::.||:..|||:|||.|.|.||.::|
Human   428 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 492

  Fly  1023 TCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLE--------TNAVSNPLYCGDDSALITTELGE 1079
            .||...|:.||||..:...||.:...::...::|        ..|||..|...:   |.|.....
Human   493 ACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPE---LPTKTRTS 554

  Fly  1080 PESLQHLWSPPKIAYDIHDQATSYDQSEEE-----------MPVTSTAPPGYDLPRPLLDATANG 1133
            ..:.:|     :...|:.:...|..|.|.:           :|.....||...|           
Human   555 RRAAEH-----RDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGL----------- 603

  Fly  1134 QVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKRGRSYLDMTNKSLIPDNLDS 1198
                .|::...|    |...|..:|.:..:...|.     ..|.||..|:.:|..:   |:...:
Human   604 ----NEDERLLP----KDKKTNLFSALIKKKKKTA-----PTPPKRSSSFREMDGQ---PERRGA 652

  Fly  1199 REFEKHLSKTISFRFSSLLNLSETKEVSP 1227
            .|.|.......:..|:.|......|...|
Human   653 GEEEGRDISNGALAFTPLDTADPAKSPKP 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 112/278 (40%)
ABL1NP_009297.2 SH3_Abl 84..137 CDD:212784
SH2_ABL 142..235 CDD:198189
PTKc_Abl 254..516 CDD:270645 115/281 (41%)
FABD 1025..1149 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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